Mir-15 microRNA precursor family (original) (raw)
The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. In humans miR-15a and miR-16 are clustered within 0.5 kilobases at chromosome position 13q14. This region has been found to be the most commonly affected in chronic lymphocytic leukaemia (CLL), with deletions of the entire region in more than half of cases. Both miR-15a and miR-16 are thus frequently deleted or down-regulated in CLL samples with 13q14 deletions; occurring in more than two thirds of CLL cases. The expression of miR-15a is associated with survival in triple negative breast canc
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| dbo:abstract | The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. In humans miR-15a and miR-16 are clustered within 0.5 kilobases at chromosome position 13q14. This region has been found to be the most commonly affected in chronic lymphocytic leukaemia (CLL), with deletions of the entire region in more than half of cases. Both miR-15a and miR-16 are thus frequently deleted or down-regulated in CLL samples with 13q14 deletions; occurring in more than two thirds of CLL cases. The expression of miR-15a is associated with survival in triple negative breast cancer. miR-15a/16-1 deletion has been shown to accelerate the proliferation of both human and mouse B-cells through modulation of the expression of genes controlling cell cycle progression. Studies have found the miR-15a/16-1 microRNA cluster to function as a tumour suppressor, with the oncogene BCL2 as its target. Specifically, miR-15a/16-1 downregulates BCL2 expression and is itself deleted or downregulated in tumour cells. There is a marked increase in BCL2 levels observed in advanced prostate tumour cases, which is inversely correlated with miR-15a/16-1 expression (and so corresponds to a decrease in miR-15a/16-1 levels). Inhibition of cell proliferation by the miR-15a/16-1 cluster occurs in both lymphoid and non-lymphoid tissue. The miR-15a/16-1 cluster has further been found to be highly expressed in CD5+ cells, therefore hinting at an important role of miR-15/16 in normal CD5+ B-cell homeostasis. (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/RF00455.jpg?width=300 |
| dbo:wikiPageExternalLink | https://archive.today/20121223083055/http:/microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl%3Facc=MI0000438 https://web.archive.org/web/20070929111540/http:/microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl%3Facc=MI0000069 |
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| dbo:wikiPageWikiLink | dbr:B-cell_chronic_lymphocytic_leukemia dbr:MicroRNA dbc:MicroRNA dbr:Homeostasis dbr:Gene dbc:MicroRNA_precursor_families dbr:G2_phase dbr:Eukaryota dbr:Cell_proliferation dbr:Hypertrophy dbr:Binucleated_cells dbr:Sequence_conservation dbr:Oncogene dbr:Non-coding_RNA dbr:Secondary_structure dbr:Chk1 |
| dbp:caption | Predicted secondary structure and sequence conservation of mir-15 (en) |
| dbp:id | RF00455 (en) |
| dbp:mirbase | MI0000069 (en) |
| dbp:mirbaseFamily | MIPF0000006 (en) |
| dbp:name | mir-15 microRNA precursor family (en) |
| dbp:rfam | RF00455 (en) |
| dbp:rnaType | dbr:MicroRNA dbr:Gene |
| dbp:symbol | mir-15 (en) |
| dbp:taxDomain | dbr:Eukaryota |
| dbp:wikiPageUsesTemplate | dbt:Cite_journal dbt:Reflist dbt:GO dbt:SO dbt:Infobox_rfam dbt:Rfam dbt:MiRNA_precursor_families |
| dcterms:subject | dbc:MicroRNA dbc:MicroRNA_precursor_families |
| rdfs:comment | The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. In humans miR-15a and miR-16 are clustered within 0.5 kilobases at chromosome position 13q14. This region has been found to be the most commonly affected in chronic lymphocytic leukaemia (CLL), with deletions of the entire region in more than half of cases. Both miR-15a and miR-16 are thus frequently deleted or down-regulated in CLL samples with 13q14 deletions; occurring in more than two thirds of CLL cases. The expression of miR-15a is associated with survival in triple negative breast canc (en) |
| rdfs:label | Mir-15 microRNA precursor family (en) |
| owl:sameAs | freebase:Mir-15 microRNA precursor family wikidata:Mir-15 microRNA precursor family https://global.dbpedia.org/id/4rZha |
| prov:wasDerivedFrom | wikipedia-en:Mir-15_microRNA_precursor_family?oldid=1043492573&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/RF00455.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Mir-15_microRNA_precursor_family |
| is dbo:wikiPageRedirects of | dbr:MicroRNA_mir-15 |
| is dbo:wikiPageWikiLink of | dbr:Oncomir dbr:Cancer_epigenetics dbr:Non-coding_RNA dbr:MicroRNA_mir-15 |
| is foaf:primaryTopic of | wikipedia-en:Mir-15_microRNA_precursor_family |
