| dbo:abstract |
أحادي البنزون (بالإنجليزية: Monobenzone) هو دواء يُستعمل في علاج: * بهاق * اضطراب التصبغ (منذ 10 نوفمبر 1952) (ar) Monobenzon ist eine chemische Verbindung aus der Gruppe der substituierten Phenole. Es ist der Monobenzylether von Hydrochinon. (de) Monobenzone, also called 4-(Benzyloxy)phenol and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH. It is used as a topical drug for medical depigmentation. It is a colourless solid that is classified as the monobenzyl ether of hydroquinone. Monobenzone is soluble in alcohol, benzene, and diethyl ether, and practically insoluble in water. (en) モノベンゾン(Monobenzone)、ハイドロキノンモノベンジルエーテル（monobenzyl ether of hydroquinone: 略称MBEH）とヒドロキノンのモノベンジルエーテルである。尋常性白斑の皮膚の脱色治療に用いる医薬品として使われる。1950年代に色素沈着や美白に使われたが白斑が生じることが判明し、日本では配合禁止をとり、米国では白斑が広範囲にわたる重症の白斑患者の白斑を完遂させるための唯一の適応症がある（商品名Benopuin）。 (ja) Monobenzon is de benzylether van hydrochinon. Het is een wit, bijna smaakloos kristallijn poeder, dat vrijwel niet oplosbaar is in water. Monobenzon is een krachtig depigmentatiemiddel. Als het op de huid wordt aangebracht zou het de afbraak van melanocyten veroorzaken, met als gevolg een verlies van melanine en een permanente depigmentatie van de huid na een periode van een tot vier maanden. Het middel Benoquin op basis van monobenzon wordt gebruikt om de huid definitief te bleken bij uitgebreide vorm van vitiligo die meer dan 50% van het lichaamsoppervlak bestrijkt. Na de dood van Michael Jackson kwam aan het licht dat hij Benoquin had gebruikt om zijn huid te bleken. (nl) Monobenzona é o éter monobenzil da hidroquinona. A aplicação tópica deste químico na pele leva à degradação progressiva da melanina e consequente diminuição da mesma. A aplicação por períodos superiores a 3 meses, pode causar a despigmentação definitiva e irreversível da pele. A monobenzona é usado para tratamento de doentes com vitiligo, a acção deste não trata especificamente as manchas de causadas pela doença, mas provoca a despigmentação da pele nas áreas circundantes trazendo dessa forma uma melhor uniformização da mesma. (pt) 4-苄氧基苯酚（或对苄氧基苯酚，英語：4-(Benzyloxy)phenol，Monobenzone，音译莫诺苯宗）是一种有机化合物，化学式为C13H12O2，是对苯二酚的单苄醚，为带有棕色色泽的透明固体，难溶于水，可燃。它有多种方法可以制得，如溴化苄和对苯二酚在氢氧化钾醇溶液中的反应，以及对苯二酚和苯甲醇在磷钼酸的催化下的反应。 (zh) |
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103-16-2 |
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1388 |
| dbo:drugbank |
DB00600 |
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9L2KA76MG5 |
| dbo:kegg |
D05072 |
| dbo:pubchem |
7638 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Monobenzone.svg?width=300 |
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https://druginfo.nlm.nih.gov/drugportal/name/monobenzone |
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Topical (en) |
| dbp:synonyms |
Hydroquinone benzyl ether, Hydroquinone monobenzyl ether, Benzyl p-hydroxyphenyl ether, Benzyl hydroquinone, Benzoquin, 4-phenol (en) |
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dbc:Phenol_ethers dbc:Phenols |
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dbr:Chemical |
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| rdfs:comment |
أحادي البنزون (بالإنجليزية: Monobenzone) هو دواء يُستعمل في علاج: * بهاق * اضطراب التصبغ (منذ 10 نوفمبر 1952) (ar) Monobenzon ist eine chemische Verbindung aus der Gruppe der substituierten Phenole. Es ist der Monobenzylether von Hydrochinon. (de) Monobenzone, also called 4-(Benzyloxy)phenol and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH. It is used as a topical drug for medical depigmentation. It is a colourless solid that is classified as the monobenzyl ether of hydroquinone. Monobenzone is soluble in alcohol, benzene, and diethyl ether, and practically insoluble in water. (en) モノベンゾン(Monobenzone)、ハイドロキノンモノベンジルエーテル（monobenzyl ether of hydroquinone: 略称MBEH）とヒドロキノンのモノベンジルエーテルである。尋常性白斑の皮膚の脱色治療に用いる医薬品として使われる。1950年代に色素沈着や美白に使われたが白斑が生じることが判明し、日本では配合禁止をとり、米国では白斑が広範囲にわたる重症の白斑患者の白斑を完遂させるための唯一の適応症がある（商品名Benopuin）。 (ja) Monobenzona é o éter monobenzil da hidroquinona. A aplicação tópica deste químico na pele leva à degradação progressiva da melanina e consequente diminuição da mesma. A aplicação por períodos superiores a 3 meses, pode causar a despigmentação definitiva e irreversível da pele. A monobenzona é usado para tratamento de doentes com vitiligo, a acção deste não trata especificamente as manchas de causadas pela doença, mas provoca a despigmentação da pele nas áreas circundantes trazendo dessa forma uma melhor uniformização da mesma. (pt) 4-苄氧基苯酚（或对苄氧基苯酚，英語：4-(Benzyloxy)phenol，Monobenzone，音译莫诺苯宗）是一种有机化合物，化学式为C13H12O2，是对苯二酚的单苄醚，为带有棕色色泽的透明固体，难溶于水，可燃。它有多种方法可以制得，如溴化苄和对苯二酚在氢氧化钾醇溶液中的反应，以及对苯二酚和苯甲醇在磷钼酸的催化下的反应。 (zh) Monobenzon is de benzylether van hydrochinon. Het is een wit, bijna smaakloos kristallijn poeder, dat vrijwel niet oplosbaar is in water. Monobenzon is een krachtig depigmentatiemiddel. Als het op de huid wordt aangebracht zou het de afbraak van melanocyten veroorzaken, met als gevolg een verlies van melanine en een permanente depigmentatie van de huid na een periode van een tot vier maanden. Het middel Benoquin op basis van monobenzon wordt gebruikt om de huid definitief te bleken bij uitgebreide vorm van vitiligo die meer dan 50% van het lichaamsoppervlak bestrijkt. (nl) |
| rdfs:label |
أحادي البنزون (ar) Monobenzon (de) モノベンゾン (ja) Monobenzone (en) Monobenzon (nl) Monobenzona (pt) 4-苄氧基苯酚 (zh) |
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