Morphiceptin is a tetrapeptide (Tyr-Pro-Phe-Pro-NH2) that is a selective μ-opioid receptor agonist. It is derived from β-casomorphin and has over 1,000 times selectivity for μ- over δ-opioid receptors. When injected intracerebroventricularly (into the ventricular system of the brain), morphiceptin had an analgesic ED50 of 1.7 nmol per animal. The analgesic effects of morphiceptin were reversed by naloxone, meaning that the analgesic effect is mediated by the μ-opioid receptor. Morphiceptin is the (1S,2S,3S,4S)-form whereas is the (1S,2S,3S,4R)-form [84799-23-5].
| Property |
Value |
| dbo:abstract |
Morphiceptin is a tetrapeptide (Tyr-Pro-Phe-Pro-NH2) that is a selective μ-opioid receptor agonist. It is derived from β-casomorphin and has over 1,000 times selectivity for μ- over δ-opioid receptors. When injected intracerebroventricularly (into the ventricular system of the brain), morphiceptin had an analgesic ED50 of 1.7 nmol per animal. The analgesic effects of morphiceptin were reversed by naloxone, meaning that the analgesic effect is mediated by the μ-opioid receptor. Morphiceptin is the (1S,2S,3S,4S)-form whereas is the (1S,2S,3S,4R)-form [84799-23-5]. (en) |
| dbo:alternativeName |
Tyr-Pro-Phe-Pro-NH2, PLO17 (en) |
| dbo:iupacName |
(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide (en) |
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wiki-commons:Special:FilePath/Morphiceptin.svg?width=300 |
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Morphiceptin.svg (en) |
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| dbp:othernames |
Tyr-Pro-Phe-Pro-NH2, PLO17 (en) |
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dbc:Tetrapeptides dbc:Analgesics dbc:Opioid_peptides |
| gold:hypernym |
dbr:Tetrapeptide |
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| rdfs:comment |
Morphiceptin is a tetrapeptide (Tyr-Pro-Phe-Pro-NH2) that is a selective μ-opioid receptor agonist. It is derived from β-casomorphin and has over 1,000 times selectivity for μ- over δ-opioid receptors. When injected intracerebroventricularly (into the ventricular system of the brain), morphiceptin had an analgesic ED50 of 1.7 nmol per animal. The analgesic effects of morphiceptin were reversed by naloxone, meaning that the analgesic effect is mediated by the μ-opioid receptor. Morphiceptin is the (1S,2S,3S,4S)-form whereas is the (1S,2S,3S,4R)-form [84799-23-5]. (en) |
| rdfs:label |
Morphiceptin (en) |
| owl:sameAs |
freebase:Morphiceptin yago-res:Morphiceptin wikidata:Morphiceptin http://azb.dbpedia.org/resource/مورفیسپتین dbpedia-fa:Morphiceptin dbpedia-sh:Morphiceptin dbpedia-sr:Morphiceptin https://global.dbpedia.org/id/4s1eU |
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dbr:PLO17 |
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dbr:List_of_opioids dbr:DAMGO dbr:Opioid dbr:Casokefamide dbr:Casomorphin dbr:Tetrapeptide dbr:PLO17 |
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wikipedia-en:Morphiceptin |
