NS-2710 (original) (raw)
NS-2710 (LS-193,970) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company NeuroSearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2710 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has anxiolytic effects comparable to chlordiazepoxide, and while it is a less potent anticonvulsant than the related drug NS-2664, it has a much longer duration of action, and similarly to other α2/α3-preferring partial agonists produces little sedative effects or physical dependence.
| Property | Value |
|---|---|
| dbo:abstract | NS-2710 (LS-193,970) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company NeuroSearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2710 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has anxiolytic effects comparable to chlordiazepoxide, and while it is a less potent anticonvulsant than the related drug NS-2664, it has a much longer duration of action, and similarly to other α2/α3-preferring partial agonists produces little sedative effects or physical dependence. (en) |
| dbo:fdaUniiCode | J0WHC91NJO |
| dbo:pubchem | 9863520 |
| dbo:thumbnail | wiki-commons:Special:FilePath/NS-2710.png?width=300 |
| dbo:wikiPageID | 18767216 (xsd:integer) |
| dbo:wikiPageLength | 3306 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1120554850 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Partial_agonist dbr:Benzodiazepine dbr:Anticonvulsant dbc:GABAA_receptor_positive_allosteric_modulators dbr:NS-2664 dbr:Anxiolytic dbc:3-Pyridyl_compounds dbc:Anxiolytics dbc:Benzimidazoles dbr:Nonbenzodiazepine dbc:Ketoximes dbr:Chlordiazepoxide dbr:NeuroSearch dbr:Sedative dbr:GABA_A_receptor |
| dbp:c | 22 (xsd:integer) |
| dbp:chemspiderid | 8039216 (xsd:integer) |
| dbp:h | 20 (xsd:integer) |
| dbp:iupacName | 1 (xsd:integer) |
| dbp:n | 4 (xsd:integer) |
| dbp:o | 1 (xsd:integer) |
| dbp:pubchem | 9863520 (xsd:integer) |
| dbp:smiles | c4ncccc4-ccccc2-n3c1cccC=NOCC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | NHJFEXZXSCFYRX-PCLIKHOPSA-N (en) |
| dbp:unii | J0WHC91NJO (en) |
| dbp:verifiedrevid | 424770500 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:GABAAR_PAMs dbt:Short_description dbt:Cascite dbt:Fdacite dbt:Anxiolytics dbt:Anxiolytic-stub |
| dcterms:subject | dbc:GABAA_receptor_positive_allosteric_modulators dbc:3-Pyridyl_compounds dbc:Anxiolytics dbc:Benzimidazoles dbc:Ketoximes |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatOximes yago:Abstraction100002137 yago:Base114618253 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Oxime114972092 yago:Part113809207 yago:PhysicalEntity100001930 yago:Pyridine114692510 yago:Relation100031921 dbo:Drug yago:Substance100019613 yago:WikicatPyridines umbel-rc:DrugProduct |
| rdfs:comment | NS-2710 (LS-193,970) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company NeuroSearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2710 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has anxiolytic effects comparable to chlordiazepoxide, and while it is a less potent anticonvulsant than the related drug NS-2664, it has a much longer duration of action, and similarly to other α2/α3-preferring partial agonists produces little sedative effects or physical dependence. (en) |
| rdfs:label | NS-2710 (en) |
| owl:sameAs | freebase:NS-2710 wikidata:NS-2710 dbpedia-sh:NS-2710 dbpedia-sr:NS-2710 https://global.dbpedia.org/id/4rzdo yago-res:NS-2710 |
| prov:wasDerivedFrom | wikipedia-en:NS-2710?oldid=1120554850&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/NS-2710.png |
| foaf:isPrimaryTopicOf | wikipedia-en:NS-2710 |
| is dbo:wikiPageWikiLink of | dbr:Nonbenzodiazepine |
| is foaf:primaryTopic of | wikipedia-en:NS-2710 |
