Nialamide (original) (raw)
نيالاميد هو مثبط أكسيداز أحادي الأمين لا عكوس وغير انتقائي من مجموعة الهيدرازين. استخدم مضادا للاكتئاب. سحبته فايزر قبل عقود بسبب مخطر تسببه بتسمم الكبد.
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| dbo:abstract | نيالاميد هو مثبط أكسيداز أحادي الأمين لا عكوس وغير انتقائي من مجموعة الهيدرازين. استخدم مضادا للاكتئاب. سحبته فايزر قبل عقود بسبب مخطر تسببه بتسمم الكبد. (ar) La nialamida (o niamida) es un inhibidor de la monoaminooxidasa (IMAO) irreversible y no selectivo derivado de la hidrazina utilizado como antidepresivo y ansiolítico. En conjunto con la fenelzina e isocarboxazida, es una de las pocas hidrazinas IMAOs aún en uso clínico. (es) Nialamide (Niamid, Niamide, Nuredal, Surgex) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity. Side effects include agitation and insomnia, less frequently dry mouth, dizziness, blurred vision, and hypomania, and rarely leukopenia and hepatitis. As with other MAOIs, a hypertensive crisis can be triggered by co-ingestion of tyramine. It is metabolized into isoniazid, an anti-tuberculosis agent, and so is contraindicated in patients with tuberculosis. The recommended dosage range is 75 to 200 mg per day, with maintenance doses as low as 12.5 mg every other day. The antiatherogenic activity of nialamide was used to design . (en) La nialamide è un inibitore irreversibile non selettivo delle monoaminossidasi A e B, appartenente alla classe chimica della idrazina. Viene utilizzato come antidepressivo e ansiolitico. (it) Nialamida (Niamid, Niamide, Nuredal, Surgex) é um inibidor da monoamina oxidase (IMAO) irreversível não-seletivo da classe hidrazina. que foi usado como um antidepressivo. Foi retirado do mercado pela Pfizer há várias décadas, devido ao risco de hepatotoxicidade. A atividade antiaterogênica da nialamida foi utilizada para a concepção do . (pt) Ниаламид (лат. Nialamidum) — лекарственное средство, антидепрессант из группы ингибиторов МАО. Белый или белый со слабым желтоватым оттенком мелкокристаллический порошок, мало растворим в воде, трудно — в спирте. В России необратимые ингибиторы МАО, в том числе ниаламид, изъяты из оборота в связи с неблагоприятным соотношением риск-польза. (ru) |
| dbo:casNumber | 51-12-7 |
| dbo:chEBI | 94510 |
| dbo:chEMBL | 1256841 |
| dbo:drugbank | DB04820 |
| dbo:fdaUniiCode | T2Q0RYM725 |
| dbo:kegg | D07337 |
| dbo:pubchem | 4472 |
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| dbo:wikiPageLength | 4255 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1121721860 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Hydrazine dbr:Pfizer dbr:Leukopenia dbc:Hydrazides dbr:Monoamine_oxidase_inhibitor dbc:Hepatotoxins dbr:Antidepressant dbr:Tuberculosis dbr:Tyramine dbc:4-Pyridyl_compounds dbc:Monoamine_oxidase_inhibitors dbc:Propionamides dbc:Withdrawn_drugs dbr:Isoniazid dbr:Hydrazine_(antidepressant) dbr:Hypertensive_crisis dbr:Hepatotoxicity dbr:Irreversible_inhibition dbr:Pyridinolcarbamate |
| dbp:atcPrefix | N06 (en) |
| dbp:atcSuffix | AF02 (en) |
| dbp:c | 16 (xsd:integer) |
| dbp:casNumber | 51 (xsd:integer) |
| dbp:chebi | 94510 (xsd:integer) |
| dbp:chembl | 1256841 (xsd:integer) |
| dbp:chemspiderid | 4317 (xsd:integer) |
| dbp:drugbank | DB04820 (en) |
| dbp:h | 18 (xsd:integer) |
| dbp:iupacName | N-benzyl-3-propanamide (en) |
| dbp:kegg | D07337 (en) |
| dbp:legalAu | S4 (en) |
| dbp:n | 4 (xsd:integer) |
| dbp:o | 2 (xsd:integer) |
| dbp:pubchem | 4472 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | O=Cc2ccncc2 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | NOIIUHRQUVNIDD-UHFFFAOYSA-N (en) |
| dbp:unii | T2Q0RYM725 (en) |
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| dcterms:subject | dbc:Hydrazides dbc:Hepatotoxins dbc:4-Pyridyl_compounds dbc:Monoamine_oxidase_inhibitors dbc:Propionamides dbc:Withdrawn_drugs |
| gold:hypernym | dbr:Inhibitor |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAmides yago:Abstraction100002137 yago:Amide114724264 yago:Base114618253 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Pyridine114692510 yago:Relation100031921 dbo:Drug yago:Substance100019613 yago:WikicatPyridines umbel-rc:DrugProduct |
| rdfs:comment | نيالاميد هو مثبط أكسيداز أحادي الأمين لا عكوس وغير انتقائي من مجموعة الهيدرازين. استخدم مضادا للاكتئاب. سحبته فايزر قبل عقود بسبب مخطر تسببه بتسمم الكبد. (ar) La nialamida (o niamida) es un inhibidor de la monoaminooxidasa (IMAO) irreversible y no selectivo derivado de la hidrazina utilizado como antidepresivo y ansiolítico. En conjunto con la fenelzina e isocarboxazida, es una de las pocas hidrazinas IMAOs aún en uso clínico. (es) La nialamide è un inibitore irreversibile non selettivo delle monoaminossidasi A e B, appartenente alla classe chimica della idrazina. Viene utilizzato come antidepressivo e ansiolitico. (it) Nialamida (Niamid, Niamide, Nuredal, Surgex) é um inibidor da monoamina oxidase (IMAO) irreversível não-seletivo da classe hidrazina. que foi usado como um antidepressivo. Foi retirado do mercado pela Pfizer há várias décadas, devido ao risco de hepatotoxicidade. A atividade antiaterogênica da nialamida foi utilizada para a concepção do . (pt) Ниаламид (лат. Nialamidum) — лекарственное средство, антидепрессант из группы ингибиторов МАО. Белый или белый со слабым желтоватым оттенком мелкокристаллический порошок, мало растворим в воде, трудно — в спирте. В России необратимые ингибиторы МАО, в том числе ниаламид, изъяты из оборота в связи с неблагоприятным соотношением риск-польза. (ru) Nialamide (Niamid, Niamide, Nuredal, Surgex) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity. The antiatherogenic activity of nialamide was used to design . (en) |
| rdfs:label | نيالاميد (ar) Nialamida (es) Nialamide (it) Nialamide (en) Nialamida (pt) Ниаламид (ru) |
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