Non-ossifying fibroma (original) (raw)
Il fibroma non ossificante è in medicina, una neoplasia (tumore) delle ossa. La sua comparsa, non grave per l'organismo è molto comune. Si manifesta soprattutto nelle metafisi del femore oppure della tibia.
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| dbo:abstract | Das nichtossifizierende Fibrom (Synonym: fibröser Kortikalisdefekt (FKD), gutartiges histiozytäres Fibrom, fibröser metaphysärer Defekt) ist eine bindegewebige tumorähnliche Knochenläsion bei Kindern und Jugendlichen. Es handelt sich um eine Entwicklungsanomalie des wachsenden Knochens, nicht um eine Neoplasie. Im Röntgenbild stellt sich das NOF meist als vielfältig runde, traubenartige scharfe Aufhellung mit girlandenartigem Randmuster dar (polyzyklisch, mit girlandenförmiger Randsklerose). Es wird davon ausgegangen, dass die NOF Ossifikationsstörungen sind. Die Herde bestehen aus kollagenreichem Bindegewebe, Fibroblasten, Histiozyten und Osteoklasten. Sie finden sich vor allem in Metaphysen langer Röhrenknochen, insbesondere der Beine. Da klinische Symptome fehlen, ist das NOF fast immer ein Zufallsbefund. Es bedarf keiner Therapie, weil eine Spontanremission mit Ersetzung der Läsionen durch Knochengewebe zu erwarten ist. (de) A non-ossifying fibroma (NOF) is a benign bone tumor of the osteoclastic giant cell-rich tumor type. It generally occurs in the metaphysis of long bones in children and adolescents. Typically, there are no symptoms unless there is a fracture. It can occur as part of a syndrome such as when multiple non-ossifying fibromas occur in neurofibromatosis, or Jaffe-Campanacci syndrome in combination with cafe-au-lait spots, mental retardation, hypogonadism, eye and cardiovascular abnormalities. Diagnosis is by X-ray or MRI, usually when investigating a person for something else. Medical imaging typically shows a well defined radiolucent lesion, with a distinct multilocular appearance, sometimes looking like bubbles. It is usually around 1-2cm in size, but be as large as 7cm. They consist of foci consist of collagen rich connective tissue, fibroblasts, histiocytes and osteoclasts. Usually no treatment is required. Surgical curettage and bone grafting may be required if it is large. It is found in 30-40% of children and adolescents, but rare in adults as most have resolved by this time. They do not become malignant. It affects twice as many males as females. A NOF was identified on the mandible of Qafzeh 9, an early anatomically modern human dated to 90–100 000 yrs B.P. (en) Il fibroma non ossificante è in medicina, una neoplasia (tumore) delle ossa. La sua comparsa, non grave per l'organismo è molto comune. Si manifesta soprattutto nelle metafisi del femore oppure della tibia. (it) |
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| dbp:caption | X-ray of nonossifying fibroma of distal tibia. (en) |
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| dbp:name | Non-ossifying fibroma (en) |
| dbp:synonyms | Fibroxanthoma (en) |
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| rdfs:comment | Il fibroma non ossificante è in medicina, una neoplasia (tumore) delle ossa. La sua comparsa, non grave per l'organismo è molto comune. Si manifesta soprattutto nelle metafisi del femore oppure della tibia. (it) Das nichtossifizierende Fibrom (Synonym: fibröser Kortikalisdefekt (FKD), gutartiges histiozytäres Fibrom, fibröser metaphysärer Defekt) ist eine bindegewebige tumorähnliche Knochenläsion bei Kindern und Jugendlichen. Es handelt sich um eine Entwicklungsanomalie des wachsenden Knochens, nicht um eine Neoplasie. Im Röntgenbild stellt sich das NOF meist als vielfältig runde, traubenartige scharfe Aufhellung mit girlandenartigem Randmuster dar (polyzyklisch, mit girlandenförmiger Randsklerose). (de) A non-ossifying fibroma (NOF) is a benign bone tumor of the osteoclastic giant cell-rich tumor type. It generally occurs in the metaphysis of long bones in children and adolescents. Typically, there are no symptoms unless there is a fracture. It can occur as part of a syndrome such as when multiple non-ossifying fibromas occur in neurofibromatosis, or Jaffe-Campanacci syndrome in combination with cafe-au-lait spots, mental retardation, hypogonadism, eye and cardiovascular abnormalities. (en) |
| rdfs:label | Nichtossifizierendes Fibrom (de) Fibroma non ossificante (it) Non-ossifying fibroma (en) |
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| foaf:name | Non-ossifying fibroma (en) |
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