Nourseothricin (original) (raw)
Nourseothricin (NTC) is a member of the -class of aminoglycoside antibiotics produced by Streptomyces species. Chemically, NTC is a mixture of the related compounds streptothricin C, D, E, and F. NTC inhibits protein synthesis by inducing miscoding. It is used as a selection marker for a wide range of organisms including bacteria, yeast, filamentous fungi, and plant cells. It is not known to have adverse side-effects on positively selected cells, a property cardinal to a selection drug.
| Property | Value |
|---|---|
| dbo:abstract | Nourseothricin (NTC) is a member of the -class of aminoglycoside antibiotics produced by Streptomyces species. Chemically, NTC is a mixture of the related compounds streptothricin C, D, E, and F. NTC inhibits protein synthesis by inducing miscoding. It is used as a selection marker for a wide range of organisms including bacteria, yeast, filamentous fungi, and plant cells. It is not known to have adverse side-effects on positively selected cells, a property cardinal to a selection drug. NTC can be inactivated by (NAT) from Streptomyces noursei, an enzyme that acetylates the beta-amino group of the beta-lysine residue of NTC. NAT can thus act as an antibiotic resistance gene. (en) |
| dbo:iupacName | [(2R,3S,4R,5R,6R)-6-[[(3aS,7R,7aS)-7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl]amino]-5-[[(3S)-3,6-diaminohexanoyl]amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] carbamate (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Nourseothricin.svg?width=300 |
| dbo:wikiPageID | 47224553 (xsd:integer) |
| dbo:wikiPageLength | 3210 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1043766664 (xsd:integer) |
| dbo:wikiPageWikiLink | dbc:Aminoglycoside_antibiotics dbc:Eukaryotic_selection_compounds dbr:Enzyme dbr:Protein_synthesis dbr:Streptomyces dbr:Marker-assisted_selection dbr:Bacteria dbr:Beta-lysine dbr:Acetylation dbr:Yeast dbr:Antibiotic_Resistance dbr:Streptomyces_noursei dbr:Plant_cell dbr:Aminoglycoside_antibiotics dbr:Filamentous_fungi dbr:Nourseothricin_N-acetyl_transferase dbr:Streptothricin |
| dbp:imagecaption | n=1-4 (en) |
| dbp:imagefile | Nourseothricin.svg (en) |
| dbp:imagesize | 200 (xsd:integer) |
| dbp:iupacname | [-6-[[-7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl]amino]-5-[[-3,6-diaminohexanoyl]amino]-4-hydroxy-2-oxan-3-yl] carbamate (en) |
| dbp:wikiPageUsesTemplate | dbt:Antibiotic-stub dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist |
| dcterms:subject | dbc:Aminoglycoside_antibiotics dbc:Eukaryotic_selection_compounds |
| gold:hypernym | dbr:Member |
| rdf:type | owl:Thing dbo:Person dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Nourseothricin (NTC) is a member of the -class of aminoglycoside antibiotics produced by Streptomyces species. Chemically, NTC is a mixture of the related compounds streptothricin C, D, E, and F. NTC inhibits protein synthesis by inducing miscoding. It is used as a selection marker for a wide range of organisms including bacteria, yeast, filamentous fungi, and plant cells. It is not known to have adverse side-effects on positively selected cells, a property cardinal to a selection drug. (en) |
| rdfs:label | Nourseothricin (en) |
| owl:sameAs | yago-res:Nourseothricin wikidata:Nourseothricin dbpedia-fa:Nourseothricin dbpedia-th:Nourseothricin dbpedia-vi:Nourseothricin https://global.dbpedia.org/id/xUc6 |
| prov:wasDerivedFrom | wikipedia-en:Nourseothricin?oldid=1043766664&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Nourseothricin.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Nourseothricin |
| is dbo:wikiPageDisambiguates of | dbr:NTC |
| is dbo:wikiPageRedirects of | dbr:C19H34N8O8 |
| is dbo:wikiPageWikiLink of | dbr:NTC dbr:Streptomyces dbr:C19H34N8O8 dbr:Candida_albicans dbr:Spizellomyces_punctatus |
| is foaf:primaryTopic of | wikipedia-en:Nourseothricin |
