| dbo:abstract |
The nuocyte is a cell of the innate immune system that plays an important role in type 2 immune responses that are induced in response to helminth worm infection or in conditions such as asthma and atopic disease. Nuocytes are amongst the first cells activated in type 2 immune responses and are thought to play important roles in activating and recruiting other cells types through their production of type 2 cytokines interleukin 4, 5 and 13. Nuocytes have been observed to proliferate in the presence of interleukin 7 (IL-7) in vitro. Nuocytes contribute to the expulsion of helminth worms and to the pathology of colitis and allergic airways disease. The nuocyte was identified at the same time as several other immune cells that play similar roles in type 2 immunity. These include Natural Helper Cells (NHCs), Innate Helper 2 (Ih2) cells and multi-potent progenitor (MPP) type 2 cells. The exact relationship between these cell types remains contentious but all share a type-2-inducing phenotype. MPP type 2 cells appear to differ from the other populations in that they have a myeloid, rather than lymphoid, origin. Nuocytes have been shown to have a lymphoid origin and a developmental pathway that is dependent upon the transcription factor RORα and Notch signalling. Pro-T cell progenitors retain nuocyte developmental potential but, unlike T cells, the thymus is dispensable for their development. (en) ナチュラルヘルパー細胞（Natural helper cell）は、2型自然リンパ球の一つである。2010年に茂呂らにより腸間膜の脂肪組織中から発見された。IL-33やIL2+ILK-25の刺激に応答して増殖し、IL5、IL6、IL13等のTh2系サイトカインを大量に分泌する。抗原特異的な受容体を持たず、抗原非特異的な免疫応答を引き起こす。寄生虫感染においては、IL-13の産生により杯細胞の過形成を誘導し、粘液分泌亢進により寄生虫の体外への排出を促進する。 類似の細胞に、nuocyte、自然2型ヘルパー細胞（Ih2細胞）、多能性前駆細胞2型（MPPtype2）がある。 (ja) |
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| dbo:wikiPageWikiLink |
dbr:Cytokine dbr:Innate_immune_system dbr:Innate_lymphoid_cell dbr:Interleukin_13 dbr:Interleukin_4 dbr:Interleukin_5 dbr:Interleukin_7 dbc:Immunology dbr:Notch_signaling_pathway dbr:Multi-potent_progenitor dbc:Human_cells dbc:Lymphocytes dbr:Thymus dbr:Asthma dbr:Atopy dbc:Cells dbc:Immune_system dbr:Colitis dbr:Parasitic_worm dbr:RAR-related_orphan_receptor_alpha dbr:Myeloid dbr:Lymphoid |
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dbt:Lymphocytes dbt:Reflist |
| dcterms:subject |
dbc:Immunology dbc:Human_cells dbc:Lymphocytes dbc:Cells dbc:Immune_system |
| gold:hypernym |
dbr:Cell |
| rdf:type |
dbo:AnatomicalStructure |
| rdfs:comment |
ナチュラルヘルパー細胞（Natural helper cell）は、2型自然リンパ球の一つである。2010年に茂呂らにより腸間膜の脂肪組織中から発見された。IL-33やIL2+ILK-25の刺激に応答して増殖し、IL5、IL6、IL13等のTh2系サイトカインを大量に分泌する。抗原特異的な受容体を持たず、抗原非特異的な免疫応答を引き起こす。寄生虫感染においては、IL-13の産生により杯細胞の過形成を誘導し、粘液分泌亢進により寄生虫の体外への排出を促進する。 類似の細胞に、nuocyte、自然2型ヘルパー細胞（Ih2細胞）、多能性前駆細胞2型（MPPtype2）がある。 (ja) The nuocyte is a cell of the innate immune system that plays an important role in type 2 immune responses that are induced in response to helminth worm infection or in conditions such as asthma and atopic disease. Nuocytes are amongst the first cells activated in type 2 immune responses and are thought to play important roles in activating and recruiting other cells types through their production of type 2 cytokines interleukin 4, 5 and 13. Nuocytes have been observed to proliferate in the presence of interleukin 7 (IL-7) in vitro. Nuocytes contribute to the expulsion of helminth worms and to the pathology of colitis and allergic airways disease. (en) |
| rdfs:label |
Nuocyte (en) ナチュラルヘルパー細胞 (ja) |
| owl:sameAs |
freebase:Nuocyte wikidata:Nuocyte wikidata:Nuocyte dbpedia-ja:Nuocyte https://global.dbpedia.org/id/4sia6 |
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wikipedia-en:Nuocyte?oldid=1120346730&ns=0 |
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wikipedia-en:Nuocyte |
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dbr:Index_of_immunology_articles dbr:Interleukin_13 dbr:Interleukin-1_family dbr:ILC2 dbr:Outline_of_immunology |
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wikipedia-en:Nuocyte |