ORG-21465 (original) (raw)
ORG-21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator. It is similar to related drugs such as ORG-20599, and was similarly developed as an improved alternative to other sedative steroids such as althesin and allopregnanolone, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use.
| Property | Value |
|---|---|
| dbo:abstract | ORG-21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator. It is similar to related drugs such as ORG-20599, and was similarly developed as an improved alternative to other sedative steroids such as althesin and allopregnanolone, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use. (en) |
| dbo:pubchem | 10697702 |
| dbo:thumbnail | wiki-commons:Special:FilePath/ORG-21465_Structure.svg?width=300 |
| dbo:wikiPageID | 25542453 (xsd:integer) |
| dbo:wikiPageLength | 2615 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1120662713 (xsd:integer) |
| dbo:wikiPageWikiLink | dbc:GABAA_receptor_positive_allosteric_modulators dbc:Hypnotics dbc:Neurosteroids dbc:Pregnanes dbr:Positive_allosteric_modulator dbr:GABAA_receptor dbr:Allopregnanolone dbc:Anticonvulsants dbc:Morpholines dbr:ORG-20599 dbr:ORG-25435 dbr:Sedative dbr:Neuroactive_steroid dbr:Althesin |
| dbp:c | 27 (xsd:integer) |
| dbp:chemspiderid | 8873045 (xsd:integer) |
| dbp:h | 43 (xsd:integer) |
| dbp:iupacName | [2-[-2--3-hydroxy-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl]methanesulfonate (en) |
| dbp:n | 1 (xsd:integer) |
| dbp:o | 7 (xsd:integer) |
| dbp:pubchem | 10697702 (xsd:integer) |
| dbp:s | 1 (xsd:integer) |
| dbp:smiles | O=SC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | SUCBEQDWLIEMEH-JDOQEMNXSA-N (en) |
| dbp:synonyms | 2 (xsd:integer) |
| dbp:verifiedrevid | 451550080 (xsd:integer) |
| dbp:width | 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Hypnotics_and_sedatives dbt:Drugbox dbt:GABAAR_PAMs dbt:Reflist dbt:See_also dbt:Short_description dbt:Sedative-stub |
| dcterms:subject | dbc:GABAA_receptor_positive_allosteric_modulators dbc:Hypnotics dbc:Neurosteroids dbc:Pregnanes dbc:Anticonvulsants dbc:Morpholines |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | ORG-21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator. It is similar to related drugs such as ORG-20599, and was similarly developed as an improved alternative to other sedative steroids such as althesin and allopregnanolone, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use. (en) |
| rdfs:label | ORG-21465 (en) |
| rdfs:seeAlso | dbr:List_of_neurosteroids |
| owl:sameAs | wikidata:ORG-21465 dbpedia-sh:ORG-21465 dbpedia-sr:ORG-21465 https://global.dbpedia.org/id/4sdNq |
| prov:wasDerivedFrom | wikipedia-en:ORG-21465?oldid=1120662713&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/ORG-21465_Structure.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:ORG-21465 |
| is dbo:wikiPageRedirects of | dbr:Org_21465 |
| is dbo:wikiPageWikiLink of | dbr:List_of_neurosteroids dbr:Org_21465 |
| is foaf:primaryTopic of | wikipedia-en:ORG-21465 |
