Omptin (original) (raw)
Omptins (EC 3.4.23.49, protease VII, protease A, gene ompT proteins, ompT protease, protein a, Pla, OmpT) are a family of bacterial proteases. They are aspartate proteases, which cleave peptides with the use of a water molecule. Found in the outer membrane of gram-negative enterobacteria such as Shigella flexneri, Yersinia pestis, Escherichia coli, and Salmonella enterica. Omptins consist of a widely conserved beta barrel spanning the membrane with 5 extracellular loops. These loops are responsible for the various substrate specificities. These proteases rely upon binding of lipopolysaccharide for activity.
| Property | Value |
|---|---|
| dbo:abstract | Omptins (EC 3.4.23.49, protease VII, protease A, gene ompT proteins, ompT protease, protein a, Pla, OmpT) are a family of bacterial proteases. They are aspartate proteases, which cleave peptides with the use of a water molecule. Found in the outer membrane of gram-negative enterobacteria such as Shigella flexneri, Yersinia pestis, Escherichia coli, and Salmonella enterica. Omptins consist of a widely conserved beta barrel spanning the membrane with 5 extracellular loops. These loops are responsible for the various substrate specificities. These proteases rely upon binding of lipopolysaccharide for activity. Omptins have been linked to bacterial pathogenesis. (en) |
| dbo:symbol | Omptin |
| dbo:wikiPageID | 31458299 (xsd:integer) |
| dbo:wikiPageLength | 2331 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 994755052 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Beta_barrel dbr:Peptide dbc:Protein_families dbr:Salmonella_enterica dbr:Lipopolysaccharide dbr:Gram-negative dbr:Escherichia_coli dbr:Enzyme_substrate_(Biology) dbr:Yersinia_pestis dbr:Protease dbc:EC_3.4.23 dbr:Pathogenesis dbc:Outer_membrane_proteins dbr:Enterobacteria dbr:Water dbr:Shigella_flexneri dbr:Aspartate |
| dbp:merops | A26 (en) |
| dbp:name | Omptin (en) |
| dbp:opmFamily | 27 (xsd:integer) |
| dbp:opmProtein | 2 (xsd:integer) |
| dbp:pfam | PF01278 (en) |
| dbp:pfamClan | CL0193 (en) |
| dbp:prosite | PDOC00657 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | Omptin (en) |
| dbp:wikiPageUsesTemplate | dbt:Cite_journal dbt:EC_number dbt:Infobox_protein_family dbt:Protein-stub dbt:Refbegin dbt:Refend dbt:Reflist dbt:Aspartic_acid_proteases |
| dct:subject | dbc:Protein_families dbc:EC_3.4.23 dbc:Outer_membrane_proteins |
| gold:hypernym | dbr:Family |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 yago:WikicatProteinFamilies |
| rdfs:comment | Omptins (EC 3.4.23.49, protease VII, protease A, gene ompT proteins, ompT protease, protein a, Pla, OmpT) are a family of bacterial proteases. They are aspartate proteases, which cleave peptides with the use of a water molecule. Found in the outer membrane of gram-negative enterobacteria such as Shigella flexneri, Yersinia pestis, Escherichia coli, and Salmonella enterica. Omptins consist of a widely conserved beta barrel spanning the membrane with 5 extracellular loops. These loops are responsible for the various substrate specificities. These proteases rely upon binding of lipopolysaccharide for activity. (en) |
| rdfs:label | オムプチン (ja) Omptin (en) |
| owl:sameAs | freebase:Omptin yago-res:Omptin wikidata:Omptin dbpedia-ja:Omptin dbpedia-sh:Omptin dbpedia-sr:Omptin https://global.dbpedia.org/id/4sqfs |
| prov:wasDerivedFrom | wikipedia-en:Omptin?oldid=994755052&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Omptin |
| is dbo:wikiPageRedirects of | dbr:Gene_ompT_proteins dbr:EC_3.4.21.87 dbr:EC_3.4.23.49 dbr:OmpT_protease |
| is dbo:wikiPageWikiLink of | dbr:List_of_EC_numbers_(EC_3) dbr:Protease_A dbr:Protease_VII dbr:Lipopolysaccharide dbr:Aspartic_protease dbr:OmpT dbr:Gene_ompT_proteins dbr:EC_3.4.21.87 dbr:EC_3.4.23.49 dbr:OmpT_protease |
| is foaf:primaryTopic of | wikipedia-en:Omptin |