| dbo:abstract |
An ovariectomized rodent (OVX) is a female rat or mouse whose ovaries have been removed. Currently there is no single animal model that identically represents the stages of osteoporosis in humans although there are some animals that are relatively close and can be used for the purpose of comparison. Both small animals and large animals are used depending on which aspects of the osteoporotic condition are being studied. Such animals include rats, rabbits, and sheep. Of these animal models, the ovariectomised rat model remains the most popular choice as it has been validated to represent the most important clinical features of estrogen deficiency-induced (or postmenopausal) bone loss in the adult human, particularly during the early stages of osteoporosis. These include: increased rate of bone turnover with resorption exceeding formation; an initial rapid phase of bone loss followed by a much slower phase; greater loss of cancellous bone than cortical bone; reduced intestinal calcium absorption; some protection against bone loss by obesity; and similar skeletal response to therapy with estrogen, tamoxifen, bisphosphonates, parathyroid hormone, calcitonin and exercise. It also offers certain advantages compared the other animal models like rabbits and sheep. These include the ability to use peripheral micro-computed tomography (pQmicro-CT) in in vivo micro-CT to perform in vivo analyses, cost-effectiveness, and ease of handling and housing. Because of these considerations, the OVX rat model is widely used for the studies relating to the prevention and treatment of osteoporosis in general as well as studies relating to the healing of osteoporotic fractures. (en) |
| dbo:wikiPageExternalLink |
http://www.osteoporosis.org.au http://users.bigpond.net.au/ac111ca/Joy/index.htm |
| dbo:wikiPageID |
16776086 (xsd:integer) |
| dbo:wikiPageLength |
3448 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1111661507 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Calcium dbr:Mouse dbr:Bisphosphonates dbr:Cancellous_bone dbr:In_vivo dbr:Estrogen dbr:Tomography dbr:Cortical_bone dbr:Animal_model dbr:Calcitonin dbr:Exercise dbr:Osteoporosis dbr:Tamoxifen dbc:Laboratory_rats dbr:Obesity dbr:Rat dbr:Ovaries dbr:Parathyroid_hormone dbr:Postmenopausal |
| dbp:wikiPageUsesTemplate |
dbt:Reflist |
| dct:subject |
dbc:Laboratory_rats |
| gold:hypernym |
dbr:Rat |
| rdf:type |
dbo:Mammal yago:WikicatModelOrganisms yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:PhysicalEntity100001930 yago:Whole100003553 |
| rdfs:comment |
An ovariectomized rodent (OVX) is a female rat or mouse whose ovaries have been removed. Currently there is no single animal model that identically represents the stages of osteoporosis in humans although there are some animals that are relatively close and can be used for the purpose of comparison. Both small animals and large animals are used depending on which aspects of the osteoporotic condition are being studied. Such animals include rats, rabbits, and sheep. (en) |
| rdfs:label |
Ovariectomized rat (en) |
| owl:sameAs |
freebase:Ovariectomized rat yago-res:Ovariectomized rat wikidata:Ovariectomized rat dbpedia-vi:Ovariectomized rat https://global.dbpedia.org/id/4spDx |
| prov:wasDerivedFrom |
wikipedia-en:Ovariectomized_rat?oldid=1111661507&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:Ovariectomized_rat |
| is dbo:wikiPageRedirects of |
dbr:OVX |
| is dbo:wikiPageWikiLink of |
dbr:Animal_disease_model dbr:Coumestrol dbr:Model_organism dbr:Neurokinin_B dbr:Selective_estrogen_receptor_modulator dbr:TRPV6 dbr:OVX |
| is foaf:primaryTopic of |
wikipedia-en:Ovariectomized_rat |