PRKAB2 (original) (raw)
5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene. The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue
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| dbo:abstract | 5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene. The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. (en) PRKAB2 (англ. Protein kinase AMP-activated non-catalytic subunit beta 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 272 амінокислот, а молекулярна маса — 30 302. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах як метаболізм жирних кислот, метаболізм ліпідів, біосинтез жирних кислот, біосинтез ліпідів. (uk) |
| dbo:wikiPageExternalLink | https://zenodo.org/record/1229938 |
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| dbo:wikiPageLength | 8696 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1081654110 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Protein-protein_interaction dbc:EC_2.7.11 dbr:Enzyme dbr:Gene dbr:Fatty_acid dbr:HMG-CoA_reductase dbr:Helicase dbr:Acetyl-CoA_carboxylase dbr:Chromatid dbr:1q21.1_deletion_syndrome dbr:1q21.1_duplication_syndrome dbr:AMP-activated_protein_kinase dbr:Cholesterol dbr:CHD1L dbr:Werner_syndrome dbr:Lymphoblast dbr:Phosphorylation dbr:PRKAG1 dbr:PRKAG2 |
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| dct:subject | dbc:EC_2.7.11 |
| gold:hypernym | dbr:Enzyme |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 dbo:HumanGene dbo:Protein |
| rdfs:comment | 5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene. The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue (en) PRKAB2 (англ. Protein kinase AMP-activated non-catalytic subunit beta 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 272 амінокислот, а молекулярна маса — 30 302. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PRKAB2 (en) PRKAB2 (uk) |
| owl:sameAs | freebase:PRKAB2 http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/851 wikidata:PRKAB2 dbpedia-cy:PRKAB2 http://tt.dbpedia.org/resource/PRKAB2 dbpedia-uk:PRKAB2 https://global.dbpedia.org/id/kGnE |
| prov:wasDerivedFrom | wikipedia-en:PRKAB2?oldid=1081654110&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:PRKAB2 |
| is dbo:wikiPageRedirects of | dbr:PRKAB2_(gene) |
| is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_3 dbr:Protein_isoform dbr:Myophosphorylase dbr:1q21.1_copy_number_variations dbr:1q21.1_deletion_syndrome dbr:1q21.1_duplication_syndrome dbr:AMP-activated_protein_kinase dbr:PRKAB2_(gene) dbr:PRKAG1 dbr:PRKAG2 |
| is foaf:primaryTopic of | wikipedia-en:PRKAB2 |