PUR4 (original) (raw)

pUR4 is a recombinant peptide that is known to inhibit the polymerization of fibronectin in a number of cell types including fibroblasts and endothelial cells. Fibronectin is an essential component of the extracellular matrix that acts as a mediator between the extracellular matrix and the cells that reside within the matrix. This cell-matrix communication occurs by binding interactions between fibronectin and matrix assembly sites on the cell surface. pUR4 interferes with these binding interaction by binding to fibronectin itself.