Penicillium parvum (original) (raw)
Penicillium parvum is an anamorph species of fungus in the genus Penicillium which was isolated from soil in Papua New Guinea. Penicillium parvum produces ferrichrome siderophores Phytochemical investigation of the soil microfungus Eupenicillum parvum led to the isolation of two new compounds: a chromone derivative euparvione and a new mycophenolic derivative euparvilactone, as well as thirteen known compounds. Several isolated compounds were evaluated for in vitro binding assays using opioid receptors (subtypes δ, κ, and μ) and cannabinoid receptors (CB1 and CB2). Compound 10 displayed the best selective μ-opioid receptor and CB1 receptor binding affinities showing values of 47% and 52% at a 10 μM concentration, respectively. These findings provide insight into the potential therapeutic u
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| dbo:abstract | Penicillium parvum is an anamorph species of fungus in the genus Penicillium which was isolated from soil in Papua New Guinea. Penicillium parvum produces ferrichrome siderophores Phytochemical investigation of the soil microfungus Eupenicillum parvum led to the isolation of two new compounds: a chromone derivative euparvione and a new mycophenolic derivative euparvilactone, as well as thirteen known compounds. Several isolated compounds were evaluated for in vitro binding assays using opioid receptors (subtypes δ, κ, and μ) and cannabinoid receptors (CB1 and CB2). Compound 10 displayed the best selective μ-opioid receptor and CB1 receptor binding affinities showing values of 47% and 52% at a 10 μM concentration, respectively. These findings provide insight into the potential therapeutic utility of this class of compounds. (en) |
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| dbo:wikiPageWikiLink | dbr:Cannabinoid_receptor dbr:In_vitro dbr:Ligand_(biochemistry) dbr:Δ-opioid_receptor dbr:Penicillium dbr:Opioid_receptor dbr:Chromone dbr:Fungus dbr:Mycophenolic_acid dbr:Microfungi dbr:Anamorph dbc:Penicillium dbr:Ferrichrome dbr:Papua_New_Guinea dbr:Kenneth_B._Raper dbr:Μ-opioid_receptor dbc:Fungi_described_in_1948 dbr:Cannabinoid_receptor_type_1 dbr:Cannabinoid_receptor_type_2 dbr:Soil dbr:Siderophore dbr:Κ-opioid_receptor dbr:Phytochemical |
| dbp:authority | Raper, K.B.; Fennell, D.I. 1948 (en) |
| dbp:genus | Penicillium (en) |
| dbp:species | parvum (en) |
| dbp:synonyms | Eupenicillium papuanum (en) Penicillium papuaneum (en) Carpenteles parvum, (en) Eupenicillium parvum, (en) Penicillium papuanum, (en) |
| dbp:typeStrain | ATCC 10479, CBS 359.48, CSIR 740, FRR 2095, IFO 7732, IMI 040587, NBRC 7732, NRRL 2095, NRRL A-809, QM 1878 (en) |
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| dct:subject | dbc:Penicillium dbc:Fungi_described_in_1948 |
| gold:hypernym | dbr:Species |
| rdf:type | dbo:Eukaryote |
| rdfs:comment | Penicillium parvum is an anamorph species of fungus in the genus Penicillium which was isolated from soil in Papua New Guinea. Penicillium parvum produces ferrichrome siderophores Phytochemical investigation of the soil microfungus Eupenicillum parvum led to the isolation of two new compounds: a chromone derivative euparvione and a new mycophenolic derivative euparvilactone, as well as thirteen known compounds. Several isolated compounds were evaluated for in vitro binding assays using opioid receptors (subtypes δ, κ, and μ) and cannabinoid receptors (CB1 and CB2). Compound 10 displayed the best selective μ-opioid receptor and CB1 receptor binding affinities showing values of 47% and 52% at a 10 μM concentration, respectively. These findings provide insight into the potential therapeutic u (en) |
| rdfs:label | Penicillium parvum (en) |
| owl:sameAs | yago-res:Penicillium parvum wikidata:Penicillium parvum https://global.dbpedia.org/id/yGKS |
| prov:wasDerivedFrom | wikipedia-en:Penicillium_parvum?oldid=1008803064&ns=0 |
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| is foaf:primaryTopic of | wikipedia-en:Penicillium_parvum |