| dbo:abstract |
Penicilloic acid is any of several acids which are obtained from the penicillins by the hydrolytic opening of the lactam ring (as by the action of a beta-lactamase).Hypersensitivity is the most important adverse effect of the penicillins. The major antigenic determinant of penicillin hypersensitivity is its metabolite, penicilloic acid, which reacts with proteins and serves as a hapten to cause an immune reaction. Approximately five percent of patients have some kind of reaction, ranging from maculopapular rash (the most common rash seen with ampicillin hypersensitivity) to angioedema (marked swelling of the lips, tongue, and periorbital area) and anaphylaxis. Among patients with mononucleosis who are treated with ampicillin, the incidence of maculopapular rash approaches 100 percent. Cross-allergic reactions occur among the β-lactam antibiotics. To determine whether treatment with a β-lactam is safe when an allergy is noted, patient history regarding severity of previous reaction is essential. (en) |
| dbo:alternativeName |
Penicilloic acid (en) |
| dbo:iupacName |
(2R,4S)-2-[(R)-Carboxy(formamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Penicilloic_acid.svg?width=300 |
| dbo:wikiPageID |
42982295 (xsd:integer) |
| dbo:wikiPageLength |
2446 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1098357785 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Metabolite dbr:Beta-lactamase dbr:Penicillins dbc:Dicarboxylic_acids dbc:Human_drug_metabolites dbr:Anaphylaxis dbr:Lactam dbr:Angioedema dbr:Maculopapular_rash dbc:Formamides dbr:Β-lactam_antibiotic dbr:Ampicillin dbr:Hapten dbr:Hypersensitivity dbc:Secondary_amino_acids dbc:Thiazolidines dbr:Hydrolytic dbr:Antigenic dbr:Periorbital dbr:Mononucleosis dbr:Immune_reaction dbr:Allergic_reactions |
| dbp:imagealt |
Structure of penicilloic acid (en) |
| dbp:imagefile |
File:Penicilloic acid.svg (en) |
| dbp:othernames |
Penicilloic acid (en) |
| dbp:pin |
-2 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Fdacite dbt:Molecular-biology-stub |
| dct:subject |
dbc:Dicarboxylic_acids dbc:Human_drug_metabolites dbc:Formamides dbc:Secondary_amino_acids dbc:Thiazolidines |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment |
Penicilloic acid is any of several acids which are obtained from the penicillins by the hydrolytic opening of the lactam ring (as by the action of a beta-lactamase).Hypersensitivity is the most important adverse effect of the penicillins. The major antigenic determinant of penicillin hypersensitivity is its metabolite, penicilloic acid, which reacts with proteins and serves as a hapten to cause an immune reaction. (en) |
| rdfs:label |
Penicilloic acid (en) |
| owl:sameAs |
freebase:Penicilloic acid yago-res:Penicilloic acid wikidata:Penicilloic acid https://global.dbpedia.org/id/nBxw |
| prov:wasDerivedFrom |
wikipedia-en:Penicilloic_acid?oldid=1098357785&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Penicilloic_acid.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Penicilloic_acid |
| is dbo:wikiPageWikiLink of |
dbr:Ampicillin |
| is dbp:metabolites of |
dbr:Ampicillin |
| is foaf:primaryTopic of |
wikipedia-en:Penicilloic_acid |
