Phasevarion (original) (raw)
In bacteria, phasevarions (also known as phase variable regulons) mediate a coordinated change in the expression of multiple genes or proteins. This occurs via phase variation of a single DNA methyltransferase. Phase variation of methyltransferase expression results in differential methylation throughout the bacterial genome, leading to variable expression of multiple genes through epigenetic mechanisms.
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| dbo:abstract | In bacteria, phasevarions (also known as phase variable regulons) mediate a coordinated change in the expression of multiple genes or proteins. This occurs via phase variation of a single DNA methyltransferase. Phase variation of methyltransferase expression results in differential methylation throughout the bacterial genome, leading to variable expression of multiple genes through epigenetic mechanisms. Phasevarions have been identified in several mucosal-associated human-adapted pathogens, which include; Haemophilus influenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Helicobacter pylori, Moraxella catarrhalis, and Streptococcus pneumoniae. All described phasevarions regulate expression of proteins that are involved in host colonization, survival, and pathogenesis, and many regulate putative vaccine targets. The presence of phasevarions complicates identification of stably expressed proteins, as the regulated genes do not contain any identifiable features. The only way to identify genes in a phasevarion is by detailed study of the organisms containing such systems. Study of the phasevarions, and identification of proteins they regulate, is therefore critical to generate effective and stable vaccines. (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Cartoon_Description_of_Phasevarion.png?width=300 |
| dbo:wikiPageID | 54306415 (xsd:integer) |
| dbo:wikiPageLength | 13093 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1082039047 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Methylation dbr:Moraxella_catarrhalis dbr:Antigen dbr:DNA_methyltransferase dbr:Vaccines dbc:Bacteria dbr:Genome dbr:Gene dbr:Colonization dbr:Haemophilus_influenzae dbr:Regulon dbr:Bacteria dbr:File:Cartoon_Description_of_Phasevarion.png dbr:Otitis_media dbr:Epigenetic dbr:Protein dbr:Restriction_enzyme dbr:Helicobacter_pylori dbr:Streptococcus_pneumoniae dbr:Pathogenesis dbr:Middle_ear dbr:Neisseria dbr:Neisseria_gonorrhoeae dbr:Neisseria_meningitidis dbr:Neutrophil dbr:Phase_variation dbr:Restriction_modification_system dbr:Oxidative_stress dbr:Bacterial_pathogen |
| dbp:wikiPageUsesTemplate | dbt:Orphan dbt:Reflist |
| dcterms:subject | dbc:Bacteria |
| rdfs:comment | In bacteria, phasevarions (also known as phase variable regulons) mediate a coordinated change in the expression of multiple genes or proteins. This occurs via phase variation of a single DNA methyltransferase. Phase variation of methyltransferase expression results in differential methylation throughout the bacterial genome, leading to variable expression of multiple genes through epigenetic mechanisms. (en) |
| rdfs:label | Phasevarion (en) |
| owl:sameAs | wikidata:Phasevarion https://global.dbpedia.org/id/4Y939 |
| prov:wasDerivedFrom | wikipedia-en:Phasevarion?oldid=1082039047&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Cartoon_Description_of_Phasevarion.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Phasevarion |
| is foaf:primaryTopic of | wikipedia-en:Phasevarion |
