| dbo:abstract |
Phosphomethylpyrimidine synthase (EC 4.1.99.17, thiC (gene)) is an enzyme with systematic name 5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming). This enzyme catalyses the following chemical reaction 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine 4-amino-2-methyl-5-phosphomethylpyrimidine + 5′-deoxyadenosine + L-methionine + formate + CO This enzyme binds a 4Fe-4S cluster. The starting material is 5-aminoimidazole ribotide, which undergoes a rearrangement reaction via radical intermediates which incorporate the blue, green and red fragments shown into the product. (en) |
| dbo:ecNumber |
4.1.99.17 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/4s27.jpg?width=300 |
| dbo:wikiPageID |
39471281 (xsd:integer) |
| dbo:wikiPageLength |
2851 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1100738123 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:5-aminoimidazole_ribotide dbr:List_of_enzymes dbc:EC_4.1.99 dbr:Chemical_reaction dbr:Enzyme dbr:Formate dbr:Rearrangement_reaction dbr:Methionine dbr:Catalysis dbr:Radical_(chemistry) dbr:S-adenosyl-L-methionine dbr:File:Pyrimidine_biosynthesis.svg |
| dbp:caption |
Phosphomethylpyrimidine synthase dimer, Arabidopsis thaliana (en) |
| dbp:ecNumber |
4.100000 (xsd:double) |
| dbp:iubmbEcNumber |
4 (xsd:integer) |
| dbp:name |
Phosphomethylpyrimidine synthase (en) |
| dbp:width |
270 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Carbon-carbon_lyases dbt:Commonscatinline dbt:EnzExplorer dbt:Enzymes dbt:Infobox_enzyme dbt:MeshName dbt:Portal_bar dbt:Reflist |
| dcterms:subject |
dbc:EC_4.1.99 |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment |
Phosphomethylpyrimidine synthase (EC 4.1.99.17, thiC (gene)) is an enzyme with systematic name 5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming). This enzyme catalyses the following chemical reaction 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine 4-amino-2-methyl-5-phosphomethylpyrimidine + 5′-deoxyadenosine + L-methionine + formate + CO This enzyme binds a 4Fe-4S cluster. (en) |
| rdfs:label |
Phosphomethylpyrimidine synthase (en) |
| owl:sameAs |
freebase:Phosphomethylpyrimidine synthase wikidata:Phosphomethylpyrimidine synthase dbpedia-sh:Phosphomethylpyrimidine synthase dbpedia-sr:Phosphomethylpyrimidine synthase https://global.dbpedia.org/id/Lzop |
| prov:wasDerivedFrom |
wikipedia-en:Phosphomethylpyrimidine_synthase?oldid=1100738123&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/4s27.jpg wiki-commons:Special:FilePath/Pyrimidine_biosynthesis.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Phosphomethylpyrimidine_synthase |
| foaf:name |
Phosphomethylpyrimidine synthase (en) |
| is dbo:wikiPageRedirects of |
dbr:5-amino-1-(5-phospho-D-ribosyl)imidazo...yl-5-phosphomethylpyrimidine-forming) dbr:EC_4.1.99.17 dbr:THIC dbr:ThiC_(gene) |
| is dbo:wikiPageWikiLink of |
dbr:Thiamine dbr:4-Amino-5-hydroxymethyl-2-methylpyrimidine dbr:5-Aminoimidazole_ribotide dbr:List_of_EC_numbers_(EC_4) dbr:5-amino-1-(5-phospho-D-ribosyl)imidazo...yl-5-phosphomethylpyrimidine-forming) dbr:EC_4.1.99.17 dbr:THIC dbr:ThiC_(gene) |
| is foaf:primaryTopic of |
wikipedia-en:Phosphomethylpyrimidine_synthase |
