Pingyangmycin (original) (raw)
Pingyangmycin (Bleomycin A5) ist ein Antibiotikum aus Streptomyces verticillus var. pingyangensis n.sp., benannt nach Pingyang (Kreis in der chinesischen Provinz Zhejiang). Streptomyceten bilden eine Gattung der Actinobacteria. Pingyangmycin ist ein Einzelverbindung aus der Stoffgruppe der Bleomycine und stellt das Spermidin-Amid der Bleomycinsäure dar. Pingyangmycin findet Verwendung als Zytostatikum in der Chemotherapie.
| Property | Value |
|---|---|
| dbo:abstract | Pingyangmycin (Bleomycin A5) ist ein Antibiotikum aus Streptomyces verticillus var. pingyangensis n.sp., benannt nach Pingyang (Kreis in der chinesischen Provinz Zhejiang). Streptomyceten bilden eine Gattung der Actinobacteria. Pingyangmycin ist ein Einzelverbindung aus der Stoffgruppe der Bleomycine und stellt das Spermidin-Amid der Bleomycinsäure dar. Pingyangmycin findet Verwendung als Zytostatikum in der Chemotherapie. (de) Pingyangmycin (also known as bleomycin A5) is an antitumor glycopeptide antibiotic belonging to the bleomycin family, which is produced by Streptomyces verticillus var. pingyangensis n.sp., a variety of Streptomyces verticillus. It was discovered in 1969 at Pingyang County of Zhejiang Province in China, and was brought into clinical use in 1978. In China, pingyangmycin has largely superseded bleomycin A2 (commonly known as "bleomycin"), since according to Chinese sources it is more effective, costs less, is easier to get, can treat a larger variety of cancers (such as breast cancer and liver cancer) and causes less lung injury. Though pingyangmycin and bleomycin can each cause pulmonary fibrosis, pingyangmycin's most serious side effect - which it does not share with bleomycin - is anaphylactic shock, which is rare, but may happen even in a low dose, and can be fatal. In addition, it causes a higher incidence of fever than bleomycin; the occurrence of this complication in patients is between 20 and 50%. (en) |
| dbo:casNumber | 11116-32-8 |
| dbo:fdaUniiCode | 5DY91Y7601 |
| dbo:pubchem | 84046 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Pingyangmycin.svg?width=300 |
| dbo:wikiPageID | 35744573 (xsd:integer) |
| dbo:wikiPageLength | 5165 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1083643301 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Cancer dbr:Amidase dbr:Pulmonary_fibrosis dbr:Bleomycin dbr:Breast_cancer dbr:Zhejiang_Province dbr:Glycopeptide_antibiotic dbr:Streptomyces_verticillus dbr:Anaphylactic_shock dbr:Liver_cancer dbc:Glycopeptide_antibiotics dbc:DNA_replication_inhibitors dbr:Fever dbr:China dbr:Kidney dbr:Pingyang_County dbr:Antitumor dbr:Lung dbr:Subspecies dbr:Side_effect dbr:Intramuscular dbr:Intravenous |
| dbp:c | 57 (xsd:integer) |
| dbp:casNumber | 11116 (xsd:integer) |
| dbp:chemspiderid | 8232875 (xsd:integer) |
| dbp:eliminationHalfLife | 4680.0 (dbd:second) |
| dbp:excretion | dbr:Kidney |
| dbp:h | 89 (xsd:integer) |
| dbp:iupacName | -2 (xsd:integer) |
| dbp:legalStatus | Rx-only (en) |
| dbp:metabolism | dbr:Amidase |
| dbp:molecularWeight | 1440.561260 (xsd:double) |
| dbp:n | 19 (xsd:integer) |
| dbp:o | 21 (xsd:integer) |
| dbp:pregnancyCategory | D (en) |
| dbp:pubchem | 84046 (xsd:integer) |
| dbp:routesOfAdministration | intravenous, intra-arterial, intramuscular, intratumoral (en) |
| dbp:s | 2 (xsd:integer) |
| dbp:smiles | C[C@@H][C@H]CNCCc1nc-c1ncCNCCCNCCCCN (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | QYOAUOAXCQAEMW-UTXKDXHTSA-N (en) |
| dbp:synonyms | Bleomycin A5 (en) |
| dbp:unii | 5 (xsd:integer) |
| dbp:width | 300 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:CAS dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Fdacite dbt:Stdinchicite |
| dct:subject | dbc:Glycopeptide_antibiotics dbc:DNA_replication_inhibitors |
| gold:hypernym | dbr:Antitumor |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCarbamates yago:Abstraction100002137 yago:Base114618253 yago:Carbamate114792281 yago:Chemical114806838 yago:Compound114818238 yago:Glycoside114887305 yago:Imidazole114916670 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Pyrimidine114999913 yago:Relation100031921 yago:WikicatGlycosides yago:WikicatImidazoles dbo:ChemicalCompound dbo:Drug yago:Salt115010703 yago:Substance100019613 yago:WikicatPyrimidines |
| rdfs:comment | Pingyangmycin (Bleomycin A5) ist ein Antibiotikum aus Streptomyces verticillus var. pingyangensis n.sp., benannt nach Pingyang (Kreis in der chinesischen Provinz Zhejiang). Streptomyceten bilden eine Gattung der Actinobacteria. Pingyangmycin ist ein Einzelverbindung aus der Stoffgruppe der Bleomycine und stellt das Spermidin-Amid der Bleomycinsäure dar. Pingyangmycin findet Verwendung als Zytostatikum in der Chemotherapie. (de) Pingyangmycin (also known as bleomycin A5) is an antitumor glycopeptide antibiotic belonging to the bleomycin family, which is produced by Streptomyces verticillus var. pingyangensis n.sp., a variety of Streptomyces verticillus. It was discovered in 1969 at Pingyang County of Zhejiang Province in China, and was brought into clinical use in 1978. (en) |
| rdfs:label | Pingyangmycin (de) Pingyangmycin (en) |
| owl:sameAs | freebase:Pingyangmycin yago-res:Pingyangmycin wikidata:Pingyangmycin dbpedia-de:Pingyangmycin dbpedia-sh:Pingyangmycin dbpedia-sr:Pingyangmycin https://global.dbpedia.org/id/2YBbB |
| prov:wasDerivedFrom | wikipedia-en:Pingyangmycin?oldid=1083643301&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Pingyangmycin.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Pingyangmycin |
| is dbo:wikiPageWikiLink of | dbr:Pulmonary_fibrosis dbr:List_of_compounds_with_carbon_numbers_50+ dbr:Bleomycin dbr:Streptomyces_verticillus dbr:Streptomyces_isolates |
| is foaf:primaryTopic of | wikipedia-en:Pingyangmycin |
