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لقاح المكورة الرئوية المتعدد السكاريد (بالإنجليزية: Pneumococcal polysaccharide vaccine) ومختصره (PPSV) هو أول لقاح للمكورة الرئوية وأول لقاح مشتق من متعدد سكاريد محفظي، وله أهمية تاريخية، ويستخدم في البالغين المعرضين لخطورة عالية. اكتشف عام 1945، لكنه لم يشتهر بسبب اكتشاف البنسلين. وفي عقد السبعينات، أنتج روبرت أوستريان نسخة المكافئ 14 (14-valent PPSV) من اللقاح. وفي عام 1983، أنتجت نسخة المكافئ 23 من اللقاح المعروفة باسم نيموفاكس 23 (Pneumovax 23) ومختصرها (PPV-23). وفي شباط 2000، رخص استخدام لقاح مكافئ كبدي متقارن ببروتين (protein conjugate heptavalent vaccine) ومختصره (PCV7). (ar) Pneumococcal polysaccharide vaccine (PPSV)—known as Pneumovax 23 (PPV-23)—is the first pneumococcal vaccine derived from a capsular polysaccharide. Its development is an important landmark in medical history. The polysaccharide antigens were used to induce type-specific antibodies that enhanced opsonization, phagocytosis, and killing of Streptococcus pneumoniae (pneumococcal) bacteria by phagocytic immune cells. The pneumococcal polysaccharide vaccine is widely used in high-risk adults. As a result, there have been important reductions in the incidence, morbidity, and mortality from invasive pneumococcal disease. First used in 1945, the tetravalent vaccine was not widely distributed, since its deployment coincided with the discovery of penicillin. In the 1970s, Robert Austrian championed the manufacture and distribution of a 14-valent PPSV. This evolved in 1983, to a 23-valent formulation (PPSV23). A significant breakthrough affecting the burden of pneumococcal disease was the licensing of a protein conjugate heptavalent vaccine (PCV7) beginning in February 2000. (en) A vacina pneumocócica polissacarídica (PPSV) - chamada de Pneumovax 23 (PPV-23) - é a primeira vacina pneumocócica derivada de um polissacarídeo capsular e um marco importante na história da medicina. Os antígenos polissacarídeos foram utilizados para induzir anticorpos específicos para o tipo que aumentaram a opsonização, fagocitose e morte de bactérias Streptococcus pneumoniae (pneumocócica) por células imunes fagocíticas. A vacina polissacarídica pneumocócica é amplamente usada em adultos de alto risco. (pt) 肺炎球菌多糖疫苗（Pneumococcal polysaccharide vaccine，PPSV）又稱23价肺炎球菌疫苗（Pneumovax 23，PPV-23），是第一个从荚膜多糖中提取的肺炎鏈球菌疫苗。多糖抗原被用来诱导特定类型的抗体，这些抗体可以增强吞噬免疫细胞對肺炎鏈球菌（肺炎球菌）的殺傷力。不少高风险的成年人已接種肺炎球菌多糖疫苗。因此，侵袭性肺炎球菌病的发病率和死亡率都有所降低。 該疫苗最初為四价疫苗，于1945年首次使用。1983年，疫苗改進為23价疫苗（PPSV23）。2000年2月开始，蛋白结合七价疫苗(PCV7)许可证頒發。 (zh) |
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لقاح المكورة الرئوية المتعدد السكاريد (بالإنجليزية: Pneumococcal polysaccharide vaccine) ومختصره (PPSV) هو أول لقاح للمكورة الرئوية وأول لقاح مشتق من متعدد سكاريد محفظي، وله أهمية تاريخية، ويستخدم في البالغين المعرضين لخطورة عالية. اكتشف عام 1945، لكنه لم يشتهر بسبب اكتشاف البنسلين. وفي عقد السبعينات، أنتج روبرت أوستريان نسخة المكافئ 14 (14-valent PPSV) من اللقاح. وفي عام 1983، أنتجت نسخة المكافئ 23 من اللقاح المعروفة باسم نيموفاكس 23 (Pneumovax 23) ومختصرها (PPV-23). وفي شباط 2000، رخص استخدام لقاح مكافئ كبدي متقارن ببروتين (protein conjugate heptavalent vaccine) ومختصره (PCV7). (ar) A vacina pneumocócica polissacarídica (PPSV) - chamada de Pneumovax 23 (PPV-23) - é a primeira vacina pneumocócica derivada de um polissacarídeo capsular e um marco importante na história da medicina. Os antígenos polissacarídeos foram utilizados para induzir anticorpos específicos para o tipo que aumentaram a opsonização, fagocitose e morte de bactérias Streptococcus pneumoniae (pneumocócica) por células imunes fagocíticas. A vacina polissacarídica pneumocócica é amplamente usada em adultos de alto risco. (pt) 肺炎球菌多糖疫苗（Pneumococcal polysaccharide vaccine，PPSV）又稱23价肺炎球菌疫苗（Pneumovax 23，PPV-23），是第一个从荚膜多糖中提取的肺炎鏈球菌疫苗。多糖抗原被用来诱导特定类型的抗体，这些抗体可以增强吞噬免疫细胞對肺炎鏈球菌（肺炎球菌）的殺傷力。不少高风险的成年人已接種肺炎球菌多糖疫苗。因此，侵袭性肺炎球菌病的发病率和死亡率都有所降低。 該疫苗最初為四价疫苗，于1945年首次使用。1983年，疫苗改進為23价疫苗（PPSV23）。2000年2月开始，蛋白结合七价疫苗(PCV7)许可证頒發。 (zh) Pneumococcal polysaccharide vaccine (PPSV)—known as Pneumovax 23 (PPV-23)—is the first pneumococcal vaccine derived from a capsular polysaccharide. Its development is an important landmark in medical history. The polysaccharide antigens were used to induce type-specific antibodies that enhanced opsonization, phagocytosis, and killing of Streptococcus pneumoniae (pneumococcal) bacteria by phagocytic immune cells. The pneumococcal polysaccharide vaccine is widely used in high-risk adults. As a result, there have been important reductions in the incidence, morbidity, and mortality from invasive pneumococcal disease. (en) |
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لقاح المكورة الرئوية المتعدد السكاريد (ar) Pneumococcal polysaccharide vaccine (en) Vacina pneumocócica polissacarídica (pt) 肺炎球菌多糖疫苗 (zh) |
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