Polygenic adaptation (original) (raw)
Polygenic adaptation describes a process in which a population adapts through small changes in allele frequencies at hundreds or thousands of loci. Many traits in humans and other species are highly polygenic, i.e., affected by standing genetic variation at hundreds or thousands of loci. Under normal conditions, the genetic variation underlying such traits is governed by stabilizing selection, in which natural selection acts to hold the population close to an optimal phenotype. However, if the phenotypic optimum changes, then the population can adapt by small directional shifts in allele frequencies spread across all the variants that affect the trait. Polygenic adaptation can occur relatively quickly (as described in the breeder's equation), however it is difficult to detect from genomic
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| dbo:abstract | Polygenic adaptation describes a process in which a population adapts through small changes in allele frequencies at hundreds or thousands of loci. Many traits in humans and other species are highly polygenic, i.e., affected by standing genetic variation at hundreds or thousands of loci. Under normal conditions, the genetic variation underlying such traits is governed by stabilizing selection, in which natural selection acts to hold the population close to an optimal phenotype. However, if the phenotypic optimum changes, then the population can adapt by small directional shifts in allele frequencies spread across all the variants that affect the trait. Polygenic adaptation can occur relatively quickly (as described in the breeder's equation), however it is difficult to detect from genomic data because the changes in allele frequencies at individual loci are very small. Polygenic adaptation represents an alternative to adaptation by selective sweeps. In classic selective sweep models, a single new mutation sweeps through a population to fixation, purging variation from a region of linkage around the selected site. More recent models have focused on partial sweeps, and on soft sweeps - i.e., sweeps that start from standing variation or comprise multiple sweeping variants at the same locus. All of these models focus on adaptation through genetic changes at a single locus and they generally assume large changes in allele frequencies. The concept of polygenic adaptation is related to classical models from quantitative genetics. However, traditional models in quantitative genetics usually abstract away the contributions of individual loci by focusing instead on means and variances of genetic scores. In contrast, population genetics models and data analysis have generally emphasized models of adaptation through sweeps at individual loci. The modern formulation of polygenic adaptation in population genetics was developed in a pair of 2010 review articles. (en) |
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| dbo:wikiPageWikiLink | dbr:Quantitative_genetics dbr:Allele_frequency dbr:Stabilizing_selection dbr:Genome-wide_association_study dbr:Population dbr:Locus_(genetics) dbr:Fixation_(population_genetics) dbc:Genetics dbr:Phenotypic_trait dbr:Phenotype dbc:Population_statistics dbr:Selective_sweep dbr:Artificial_Selection dbr:Breeder's_equation dbr:Polygenic_trait |
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| rdfs:comment | Polygenic adaptation describes a process in which a population adapts through small changes in allele frequencies at hundreds or thousands of loci. Many traits in humans and other species are highly polygenic, i.e., affected by standing genetic variation at hundreds or thousands of loci. Under normal conditions, the genetic variation underlying such traits is governed by stabilizing selection, in which natural selection acts to hold the population close to an optimal phenotype. However, if the phenotypic optimum changes, then the population can adapt by small directional shifts in allele frequencies spread across all the variants that affect the trait. Polygenic adaptation can occur relatively quickly (as described in the breeder's equation), however it is difficult to detect from genomic (en) |
| rdfs:label | Polygenic adaptation (en) |
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