| dbo:abstract |
A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of the genome ensures that each daughter cell will carry the same genetic information as the parent cell. Accordingly, formation of the pre-RC is a very important part of the cell cycle. (en) Il complesso di pre-replicazione (in inglese pre-Replication Complex, o pre-RC) è un complesso multiproteico che nelle cellule eucariote si assembla sulle origini di replicazione del DNA il cui ruolo è quello di iniziare la replicazione del DNA. L'assemblaggio del complesso sulle origini di replicazione avviene durante la fase M tardiva e prosegue nella fase G1 precoce del ciclo cellulare, quando i livelli delle cicline sono bassi. Il livello basso di cicline consente infatti la formazione del pre-RC ma non ne permette l'attivazione, che richiede invece alti livelli di cicline E ed A: questo è uno dei più importanti meccanismi che impedisce la doppia replicazione di una stessa regione di DNA all'interno di un solo ciclo. La regolazione dell'assemblaggio del pre-RC è dunque il processo fondamentale che fa sì che durante la replicazione cellulare non vengano lasciate regioni di DNA non replicate o che altre regioni vengano replicate più di una volta. (it) 複製前複合体または複製開始前複合体（ふくせい(かいし)まえふくごうたい、英: pre-replication complex、略称: pre-RC）は、DNA複製の開始段階に複製起点に形成されるタンパク質複合体である。pre-RCの形成はDNA複製が起こるために必要である。ゲノムの完全に忠実に複製されることによって、各娘細胞が親細胞と同一の遺伝情報を持つことが保証される。したがって、pre-RCの形成は細胞周期の非常に重要な部分をなしている。 (ja) Пререпликацио́нный ко́мплекс (англ. pre-replication complex, pre-RC) — комплекс белков, который образуется на стадии инициации репликации ДНК. Белки, которые принимают участие в пререпликационном комплексе, строго необходимы для репликации. (ru) |
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| rdfs:comment |
A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of the genome ensures that each daughter cell will carry the same genetic information as the parent cell. Accordingly, formation of the pre-RC is a very important part of the cell cycle. (en) 複製前複合体または複製開始前複合体（ふくせい(かいし)まえふくごうたい、英: pre-replication complex、略称: pre-RC）は、DNA複製の開始段階に複製起点に形成されるタンパク質複合体である。pre-RCの形成はDNA複製が起こるために必要である。ゲノムの完全に忠実に複製されることによって、各娘細胞が親細胞と同一の遺伝情報を持つことが保証される。したがって、pre-RCの形成は細胞周期の非常に重要な部分をなしている。 (ja) Пререпликацио́нный ко́мплекс (англ. pre-replication complex, pre-RC) — комплекс белков, который образуется на стадии инициации репликации ДНК. Белки, которые принимают участие в пререпликационном комплексе, строго необходимы для репликации. (ru) Il complesso di pre-replicazione (in inglese pre-Replication Complex, o pre-RC) è un complesso multiproteico che nelle cellule eucariote si assembla sulle origini di replicazione del DNA il cui ruolo è quello di iniziare la replicazione del DNA. (it) |
| rdfs:label |
Complesso di pre-replicazione (it) 複製前複合体 (ja) Pre-replication complex (en) Пререпликационный комплекс (ru) |
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