Progesterone 5alpha-reductase (original) (raw)
La progesterone 5alfa-reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 5α-pregnan-3,20-dione + NADP+ ⇄ progesterone + NADPH + H+ Il testosterone ed il 20α-idrossi-4-pregn-3-one possono agire al posto del progesterone.
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| dbo:abstract | In enzymology, a progesterone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction 5alpha-pregnan-3,20-dione + NADP+ progesterone + NADPH + H+ Thus, the two substrates of this enzyme are and NADP+, whereas its 3 products are progesterone, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. It is a C21-steroid hormone that is a 5α-pregnane substituted with a oxo groups at positions 3 and 20. It is an intermediate in the conversion of progesterone to allopregnalone and isopregnanolone, other common forms of neurosteroids. The systematic name of this enzyme class is 5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase. Other names in common use include steroid 5-alpha-reductase, and Delta4-steroid 5alpha-reductase (progesterone). (en) La progesterone 5alfa-reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 5α-pregnan-3,20-dione + NADP+ ⇄ progesterone + NADPH + H+ Il testosterone ed il 20α-idrossi-4-pregn-3-one possono agire al posto del progesterone. (it) プロゲステロン-5α-レダクターゼ（progesterone 5α-reductase）は、ステロイドホルモン生合成酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 5α-ジヒドロプロゲステロン + NADP+ プロゲステロン + NADPH + H+ 反応式の通り、この酵素の基質はとNADP+、生成物はプロゲステロンとNADPHとH+である。 組織名は5α-pregnan-3,20-dione:NADP+ 5-oxidoreductaseで、別名にsteroid 5-α-reductase, Δ4-steroid 5α-reductase (progesterone)がある。 (ja) |
| dbo:ecNumber | 1.3.1.22 |
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| dbp:name | progesterone 5-alpha-reductase (en) |
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| dct:subject | dbc:EC_1.3.1 dbc:Enzymes_of_unknown_structure dbc:NADPH-dependent_enzymes |
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| rdfs:comment | La progesterone 5alfa-reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 5α-pregnan-3,20-dione + NADP+ ⇄ progesterone + NADPH + H+ Il testosterone ed il 20α-idrossi-4-pregn-3-one possono agire al posto del progesterone. (it) プロゲステロン-5α-レダクターゼ（progesterone 5α-reductase）は、ステロイドホルモン生合成酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 5α-ジヒドロプロゲステロン + NADP+ プロゲステロン + NADPH + H+ 反応式の通り、この酵素の基質はとNADP+、生成物はプロゲステロンとNADPHとH+である。 組織名は5α-pregnan-3,20-dione:NADP+ 5-oxidoreductaseで、別名にsteroid 5-α-reductase, Δ4-steroid 5α-reductase (progesterone)がある。 (ja) In enzymology, a progesterone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction 5alpha-pregnan-3,20-dione + NADP+ progesterone + NADPH + H+ Thus, the two substrates of this enzyme are and NADP+, whereas its 3 products are progesterone, NADPH, and H+. (en) |
| rdfs:label | Progesterone 5alfa-reduttasi (it) プロゲステロン-5α-レダクターゼ (ja) Progesterone 5alpha-reductase (en) |
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| foaf:name | progesterone 5-alpha-reductase (en) |
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