| dbo:abstract |
Proglucagón es el nombre del precursor inactivo de la hormona glucagón, así como de otros compuestos bioquímicos. Es producido por las células alfa del páncreas así como por las células L en el intestino delgado. (es) Le proglucagon est une protéine qui provient du clivage du préproglucagon. Chez l'homme, ce dernier est codé par le gène GCG. Le proglucagon est un précurseur du glucagon et de plusieurs autres composants. Il est synthétisé dans les cellules alpha des îlots de Langerhans du pancréas et dans les (ou entéro-endocrines) intestinales de l'iléon distal et du côlon. Il est divisé en les composants suivants : * * glicentine (GRPP) * Oxyntomoduline (OXY ou OXM) * Glucagon * Peptide de type glucagon 1 ( GLP-1 ) * Peptide 2 de type glucagon (fr) Proglucagon is a protein that is cleaved from preproglucagon. Preproglucagon in humans is encoded by the GCG gene. Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. It is also cleaved into the following components in different organs: * Signal peptide (1-20) – removed from preproglucagon to form proglucagon * (21–89) * (GRPP, 21-50) * Oxyntomodulin (OXY or OXM, 53–89) * Glucagon (53–81) * Glucagon-like peptide 1 (GLP-1, 92–128) – first seven residues further cleaved * Glucagon-like peptide 2 (GLP-2, 146–178) Proglucagon itself is a protein with three repeats of slightly different secretin family hormones to be cleaved to form mature hormones. (en) |
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| rdfs:comment |
Proglucagón es el nombre del precursor inactivo de la hormona glucagón, así como de otros compuestos bioquímicos. Es producido por las células alfa del páncreas así como por las células L en el intestino delgado. (es) Le proglucagon est une protéine qui provient du clivage du préproglucagon. Chez l'homme, ce dernier est codé par le gène GCG. Le proglucagon est un précurseur du glucagon et de plusieurs autres composants. Il est synthétisé dans les cellules alpha des îlots de Langerhans du pancréas et dans les (ou entéro-endocrines) intestinales de l'iléon distal et du côlon. Il est divisé en les composants suivants : * * glicentine (GRPP) * Oxyntomoduline (OXY ou OXM) * Glucagon * Peptide de type glucagon 1 ( GLP-1 ) * Peptide 2 de type glucagon (fr) Proglucagon is a protein that is cleaved from preproglucagon. Preproglucagon in humans is encoded by the GCG gene. Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. It is also cleaved into the following components in different organs: Proglucagon itself is a protein with three repeats of slightly different secretin family hormones to be cleaved to form mature hormones. (en) |
| rdfs:label |
Proglucagón (es) Proglucagon (fr) Proglucagon (en) |
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wikipedia-en:Proglucagon |
