Protein N-terminal methyltransferase (original) (raw)
Protein N-terminal methyltransferase (EC 2.1.1.244, NMT1 (gene), METTL11A (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase. This enzyme catalyses the following chemical reaction This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys.
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| dbo:abstract | Protein N-terminal methyltransferase (EC 2.1.1.244, NMT1 (gene), METTL11A (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase. This enzyme catalyses the following chemical reaction (1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] (overall reaction)(1a) S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,S)PK-[protein](1b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-(A,S)PK-[protein] S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-(A,S)PK-[protein](1c) S-adenosyl-L-methionine + N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein] S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein](2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] (overall reaction)(2a) S-adenosyl-L-methionine + N-terminal-PPK-[protein] S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-PPK-[protein](2b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-PPK-[protein] S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys. (en) |
| dbo:ecNumber | 2.1.1.244 |
| dbo:wikiPageID | 38609162 (xsd:integer) |
| dbo:wikiPageLength | 2774 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 918609866 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:List_of_enzymes dbc:EC_2.1.1 dbr:Chemical_reaction dbr:Enzyme dbr:Catalysis dbr:N-terminus dbr:S-adenosyl-L-homocysteine dbr:S-adenosyl-L-methionine |
| dbp:ecNumber | 2.100000 (xsd:double) |
| dbp:iubmbEcNumber | 2 (xsd:integer) |
| dbp:name | Protein N-terminal methyltransferase (en) |
| dbp:wikiPageUsesTemplate | dbt:EC_number dbt:Enzymes dbt:Infobox_enzyme dbt:MeshName dbt:One_carbon_transferases dbt:Portal_bar dbt:Reflist |
| dct:subject | dbc:EC_2.1.1 |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | Protein N-terminal methyltransferase (EC 2.1.1.244, NMT1 (gene), METTL11A (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase. This enzyme catalyses the following chemical reaction This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys. (en) |
| rdfs:label | Protein N-terminal methyltransferase (en) |
| owl:sameAs | freebase:Protein N-terminal methyltransferase wikidata:Protein N-terminal methyltransferase dbpedia-sh:Protein N-terminal methyltransferase dbpedia-sr:Protein N-terminal methyltransferase https://global.dbpedia.org/id/4hqx8 |
| prov:wasDerivedFrom | wikipedia-en:Protein_N-terminal_methyltransferase?oldid=918609866&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Protein_N-terminal_methyltransferase |
| foaf:name | Protein N-terminal methyltransferase (en) |
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| is dbo:wikiPageWikiLink of | dbr:Glycylpeptide_N-tetradecanoyltransferase_1 dbr:List_of_EC_numbers_(EC_2) dbr:S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein)_methyltransferase dbr:S-adenozil-L-metionin:N-terminal-(A,P,S)PK-(protein)_methyltransferase dbr:EC_2.1.1.244 dbr:METTL11A dbr:METTL11A_(gene) |
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