Protide (original) (raw)

The ProTide technology is a prodrug approach used in molecular biology and drug design. It is designed to deliver nucleotide analogues (as monophosphate) into the cell (ProTide: PROdrug + nucleoTIDE). It was invented by Professor Chris McGuigan (School of Pharmacy and Pharmaceutical Sciences, Cardiff University) in the early 1990s. They form a critical part of the anti-viral drugs: sofosbuvir, tenofovir alafenamide and remdesivir.