Protodioscin (original) (raw)
Protodioscin is a steroidal saponin compound found in a number of plant species, most notably in the Tribulus, Trigonella Dioscorea and Trillium families. It is best known as the putative active component of the herbal aphrodisiac plant Tribulus terrestris.
| Property | Value |
|---|---|
| dbo:abstract | Protodioscin is a steroidal saponin compound found in a number of plant species, most notably in the Tribulus, Trigonella Dioscorea and Trillium families. It is best known as the putative active component of the herbal aphrodisiac plant Tribulus terrestris. Extracts from T. terrestris standardised for protodioscin content have been demonstrated to produce proerectile effects in isolated tissues and aphrodisiac action in several animal species. It is thought protodioscin achieves this primarily through causing an increase in androgen receptor immunoreacivity, meaning it increases the concentration of androgen receptors in cells, causing the organism to become more sensitive to androgens like testosterone and dihydrotestosterone (DHT). The mechanism for these effects has not been clearly established, and while protodioscin has been demonstrated to trigger release of nitric oxide in corpus cavernosum tissue, and also to produce statistically significant increases in the levels of the hormones testosterone, dihydrotestosterone and dehydroepiandrosterone in animal studies, studies in humans have failed to show efficacy and its use remains controversial. (en) Protodioscyna – steroidowy, organiczny związek chemiczny z grupy saponin. Występuje w wielu roślinach, głównie z rodzajów: , Trigonella i Dioscorea. Jest także aktywnym składnikiem buzdyganka naziemnego – rośliny używanej jako afrodyzjak. Wykazano, że wyciąg z buzdyganka naziemnego standaryzowany na zawartość protodioscyny wspomaga erekcję (badania na izolowanych tkankach) oraz działa jak afrodyzjak na niektóre gatunki zwierząt. Mechanizm działania protodioscyny nie jest w pełni jasny, chociaż wykazano, że substancja ta powoduje uwalnianie tlenku azotu w ciałach jamistych penisa oraz podnosi poziom testosteronu, dihydrotestosteronu i dehydroepiandrosteronu we krwi. Dowody skuteczności protodioscyny u ludzi są ograniczone i pozostają kontrowersyjne. (pl) |
| dbo:casNumber | 55056-80-9 |
| dbo:fdaUniiCode | D0LC3PH24P |
| dbo:pubchem | 441891 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Protodioscin.png?width=300 |
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| dbo:wikiPageLength | 7671 (xsd:nonNegativeInteger) |
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| dbo:wikiPageWikiLink | dbr:Tribulus dbr:Dehydroepiandrosterone dbr:Aphrodisiac dbc:Steroidal_glycosides dbr:Corpus_cavernosum_penis dbr:Steroid dbr:Trillium dbr:Nitric_oxide dbr:Dioscorea dbr:Testosterone dbc:Saponins dbr:Efficacy dbr:Saponin dbr:Dihydrotestosterone dbr:Trigonella dbr:Tribulus_terrestris |
| dbp:atcPrefix | none (en) |
| dbp:c | 51 (xsd:integer) |
| dbp:casNumber | 55056 (xsd:integer) |
| dbp:chemspiderid | 390467 (xsd:integer) |
| dbp:h | 84 (xsd:integer) |
| dbp:iupacName | 26 (xsd:integer) |
| dbp:legalStatus | Legal (en) |
| dbp:o | 22 (xsd:integer) |
| dbp:pubchem | 441891 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | C[C@H]1[C@H]2[C@H]O[C@@]1O (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | LVTJOONKWUXEFR-UEZXSUPNSA-N (en) |
| dbp:unii | D0LC3PH24P (en) |
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| dbp:width | 340 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite |
| dct:subject | dbc:Steroidal_glycosides dbc:Saponins |
| gold:hypernym | dbr:Compound |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMolecularFormulas yago:WikicatSaponins yago:WikicatSteroidalGlycosides yago:WikicatSteroids yago:Abstraction100002137 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Glucoside114887801 yago:Glycoside114887305 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 yago:WikicatGlycosides dbo:ChemicalCompound dbo:Drug yago:Saponin114887925 yago:Statement106722453 yago:Steroid115057744 yago:Substance100019613 |
| rdfs:comment | Protodioscin is a steroidal saponin compound found in a number of plant species, most notably in the Tribulus, Trigonella Dioscorea and Trillium families. It is best known as the putative active component of the herbal aphrodisiac plant Tribulus terrestris. (en) Protodioscyna – steroidowy, organiczny związek chemiczny z grupy saponin. Występuje w wielu roślinach, głównie z rodzajów: , Trigonella i Dioscorea. Jest także aktywnym składnikiem buzdyganka naziemnego – rośliny używanej jako afrodyzjak. (pl) |
| rdfs:label | Protodioscin (en) Protodioscyna (pl) |
| owl:sameAs | freebase:Protodioscin yago-res:Protodioscin wikidata:Protodioscin dbpedia-pl:Protodioscin dbpedia-sh:Protodioscin dbpedia-sr:Protodioscin dbpedia-vi:Protodioscin https://global.dbpedia.org/id/4tjgC |
| prov:wasDerivedFrom | wikipedia-en:Protodioscin?oldid=1034018312&ns=0 |
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| is dbo:wikiPageWikiLink of | dbr:List_of_compounds_with_carbon_numbers_50+ dbr:C51H84O22 |
| is foaf:primaryTopic of | wikipedia-en:Protodioscin |
