Rapid eye movement sleep behaviour disorder and Parkinson's disease (original) (raw)
Rapid eye movement sleep behaviour disorder and Parkinson’s disease is rapid eye movement sleep behavior disorder (RBD) that is associated with Parkinson's disease. RBC is linked genetically and neuropathologically to α- synuclein, a presynaptic neuronal protein that exerts deleterious effects on neighbouring proteins, leading to neuronal death. This pathology is linked to numerous other neurodegenerative disorders, such as Lewy bodies dementia, and collectively these disorders are known as synucleinopathies. Numerous reports over the past few years have stated the frequent association of synucleinopathies with REM sleep behaviour disorder (RBD). In particular, the frequent association of RBD with Parkinson’s. In the general population the incidence of RBD is around 0.5%, compared to the p
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| dbo:abstract | Rapid eye movement sleep behaviour disorder and Parkinson’s disease is rapid eye movement sleep behavior disorder (RBD) that is associated with Parkinson's disease. RBC is linked genetically and neuropathologically to α- synuclein, a presynaptic neuronal protein that exerts deleterious effects on neighbouring proteins, leading to neuronal death. This pathology is linked to numerous other neurodegenerative disorders, such as Lewy bodies dementia, and collectively these disorders are known as synucleinopathies. Numerous reports over the past few years have stated the frequent association of synucleinopathies with REM sleep behaviour disorder (RBD). In particular, the frequent association of RBD with Parkinson’s. In the general population the incidence of RBD is around 0.5%, compared to the prevalence of RBD in PD patients, which has been reported to be between 38% to 60%. The diagnosis and symptom onset of RBD typically precedes the onset of motor or cognitive symptoms of PD by a number of years, typically ranging anywhere from 2 to 15 years prior. Hence, this link could provide an important window of opportunity in the implementation of therapies and treatments, that could prevent or slow the onset of PD. (en) |
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| dbo:wikiPageWikiLink | dbc:Parkinson's_disease dbr:Dementia dbr:Visuospatial_sketchpad dbr:Dopaminergic dbr:Insular_cortex dbr:Neurotransmitter dbr:Lewy_body dbr:Lewy_body_dementias dbr:Neurodegeneration dbr:Genetics dbr:Neuron dbr:Neuropathology dbr:Substantia_nigra dbr:Frontal_lobe dbr:Braak_staging dbr:Brainstem dbr:Cross-sectional_data dbr:Cholinergic dbr:Cholinergic_neuron dbr:Denervation dbr:Hallucination dbr:Idiopathic_disease dbr:Pathology dbr:Tremor dbr:Drug-naïve dbr:Alpha-synuclein dbr:Executive_functions dbr:Basal_forebrain dbr:Parkinson's_disease dbc:Neuropathology dbr:Rapid_eye_movement_sleep dbr:Grey_matter dbr:Hypokinesia dbc:Sleep_disorders dbr:Acetylcholinesterase_inhibitor dbr:Language dbr:Cognition dbr:Cognitive_test dbr:Pathogenesis dbr:Dopamine dbr:Phenotype dbr:Polysomnography dbr:Inferior_parietal_lobule dbr:Methodology dbr:Midbrain dbr:Rapid_eye_movement_sleep_behavior_disorder dbr:Cerebral_cortex dbr:Working_memory dbr:Longitudinal_study dbr:Mild_cognitive_impairment dbr:Sleep dbr:Neurological_disorder dbr:Synucleinopathy dbr:Signs_and_symptoms dbr:Cognitive_dysfunction dbr:Cognitive_function |
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| dcterms:subject | dbc:Parkinson's_disease dbc:Neuropathology dbc:Sleep_disorders |
| rdfs:comment | Rapid eye movement sleep behaviour disorder and Parkinson’s disease is rapid eye movement sleep behavior disorder (RBD) that is associated with Parkinson's disease. RBC is linked genetically and neuropathologically to α- synuclein, a presynaptic neuronal protein that exerts deleterious effects on neighbouring proteins, leading to neuronal death. This pathology is linked to numerous other neurodegenerative disorders, such as Lewy bodies dementia, and collectively these disorders are known as synucleinopathies. Numerous reports over the past few years have stated the frequent association of synucleinopathies with REM sleep behaviour disorder (RBD). In particular, the frequent association of RBD with Parkinson’s. In the general population the incidence of RBD is around 0.5%, compared to the p (en) |
| rdfs:label | Rapid eye movement sleep behaviour disorder and Parkinson's disease (en) |
| owl:sameAs | wikidata:Rapid eye movement sleep behaviour disorder and Parkinson's disease https://global.dbpedia.org/id/GdrFf |
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