| dbo:abstract |
Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin).RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth. (en) |
| dbo:arm |
q |
| dbo:band |
21.1 21.2 26.1 |
| dbo:chromosome |
1 5 15 |
| dbo:entrezgene |
148738 285704 56963 |
| dbo:hgncid |
4887 26896 30308 |
| dbo:omim |
607362 (xsd:integer) 608374 (xsd:integer) 612687 (xsd:integer) |
| dbo:refseq |
NM_020211 NM_145277 NM_173670 |
| dbo:symbol |
DRAGON HFE2 RGM RGMA RGMB RGMC, HJV, hemojuvelin |
| dbo:uniprot |
Q6NW40 Q6ZVN8 Q96B86 |
| dbo:wikiPageID |
18156469 (xsd:integer) |
| dbo:wikiPageLength |
2419 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1116592674 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Gene_family dbr:Hemojuvelin dbc:Proteins dbr:Traumatic_brain_injury dbc:Developmental_biology dbr:Granulation_tissue dbr:Neural_development dbr:Retinal_ganglion_cell dbr:Axon dbr:Axon_guidance dbr:Spinal_cord_injury dbr:Mesencephalon dbr:Midbrain_tectum dbr:RGMA dbr:RGMB |
| dbp:altsymbols |
DRAGON (en) RGM (en) RGMC, HJV, hemojuvelin (en) |
| dbp:arm |
q (en) |
| dbp:band |
21.100000 (xsd:double) 21.200000 (xsd:double) 26.100000 (xsd:double) |
| dbp:chromosome |
1 (xsd:integer) 5 (xsd:integer) 15 (xsd:integer) |
| dbp:entrezgene |
56963 (xsd:integer) 148738 (xsd:integer) 285704 (xsd:integer) |
| dbp:hgncid |
4887 (xsd:integer) 26896 (xsd:integer) 30308 (xsd:integer) |
| dbp:name |
dbr:Hemojuvelin dbr:RGMA dbr:RGMB |
| dbp:omim |
607362 (xsd:integer) 608374 (xsd:integer) 612687 (xsd:integer) |
| dbp:refseq |
NM_020211 (en) NM_145277 (en) NM_173670 (en) |
| dbp:symbol |
dbr:Hemojuvelin dbr:RGMA dbr:RGMB |
| dbp:uniprot |
Q6NW40 (en) Q6ZVN8 (en) Q96B86 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Reflist dbt:Short_description dbt:Infobox_protein |
| dct:subject |
dbc:Proteins dbc:Developmental_biology |
| gold:hypernym |
dbr:Members |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins |
| rdfs:comment |
Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin).RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth. (en) |
| rdfs:label |
Repulsive guidance molecule (en) |
| owl:sameAs |
freebase:Repulsive guidance molecule yago-res:Repulsive guidance molecule wikidata:Repulsive guidance molecule https://global.dbpedia.org/id/7Safx |
| prov:wasDerivedFrom |
wikipedia-en:Repulsive_guidance_molecule?oldid=1116592674&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:Repulsive_guidance_molecule |
| foaf:name |
RGM domain family, member A (en) RGM domain family, member B (en) hemochromatosis type 2 (en) |
| is dbo:wikiPageWikiLink of |
dbr:Hemojuvelin dbr:Repulsive_guidance_molecule_B dbr:Repulsive_guidance_molecule_A |
| is foaf:primaryTopic of |
wikipedia-en:Repulsive_guidance_molecule |