Ribonuclease Z (original) (raw)
TRNase Z (EC 3.1.26.11, 3 tRNase, tRNA 3 endonuclease, RNase Z, 3' tRNase) is an enzyme that, among other things, catalyses the reactions involved in the maturation of tRNAs. Here, it endonucleolytically cleaves the RNA and removes extra 3' nucleotides from the tRNA precursor, generating the 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. Similarly, it processes tRNA-like molecules such as mascRNA. The enzyme does not use a cofactor.
| Property | Value |
|---|---|
| dbo:abstract | TRNase Z (EC 3.1.26.11, 3 tRNase, tRNA 3 endonuclease, RNase Z, 3' tRNase) is an enzyme that, among other things, catalyses the reactions involved in the maturation of tRNAs. Here, it endonucleolytically cleaves the RNA and removes extra 3' nucleotides from the tRNA precursor, generating the 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. Similarly, it processes tRNA-like molecules such as mascRNA. The enzyme does not use a cofactor. (en) リボヌクレアーゼZ(Ribonuclease Z、EC 3.1.26.11)は、以下の化学反応を触媒する酵素である。 リボ核酸をエンド型で切断する。転移RNA前駆体の3'末端についた余計なヌクレオチドを除去し、3'末端を生成する。3'-ヒドロキシ基は転移RNAの末端に残り、5'-ホスホリル基は後ろの分子に残る。 この酵素は、補因子を必要としない。 (ja) 核糖核酸酶Z（Ribonuclease Z、RNase Z、3′ tRNase，在不同生物中的名稱包括ElaC、ZiPD、RNase BN、TRZ1等）是一種參與tRNA生合成的核糖核酸酶，為內切酶，屬鋅依賴型金屬水解酶，編碼此蛋白的基因於2002年被發現。 tRNA基因轉錄產生tRNA前驅物（pre-tRNA）後，其5′端會被核糖核酸酶P切割，3′端則被核糖核酸酶Z切割，隨後再由在其3′端加上CCA三個鹼基，以生成成熟的tRNA。核糖核酸酶Z切割位點下游位點的CC會抑制其切割活性，因此已被加上CCA的成熟tRNA不會再被其切割，此外tRNA前驅物5′端序列的長度也可能影響核糖核酸酶Z切割的活性。 釀酒酵母、大腸桿菌、枯草桿菌、海栖热袍菌等生物的核糖核酸酶Z結構均已被解出。 (zh) |
| dbo:ecNumber | 3.1.26.11 |
| dbo:wikiPageID | 39057757 (xsd:integer) |
| dbo:wikiPageLength | 3692 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1044706817 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Nucleotide dbr:Enzyme dbr:Phosphoryl dbr:MALAT1-associated_small_cytoplasmic_RNA dbc:EC_3.1.26 dbr:RNA dbr:Hydroxy_group dbr:Cofactor_(biochemistry) dbr:Catalysis dbr:TRNA |
| dbp:casNumber | 98148 (xsd:integer) |
| dbp:ecNumber | 3.100000 (xsd:double) |
| dbp:iubmbEcNumber | 3 (xsd:integer) |
| dbp:name | TRNase Z (en) |
| dbp:wikiPageUsesTemplate | dbt:EC_number dbt:Enzymes dbt:Esterases dbt:Infobox_enzyme dbt:MeshName dbt:Portal_bar dbt:Reflist |
| dct:subject | dbc:EC_3.1.26 |
| gold:hypernym | dbr:Enzyme |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | TRNase Z (EC 3.1.26.11, 3 tRNase, tRNA 3 endonuclease, RNase Z, 3' tRNase) is an enzyme that, among other things, catalyses the reactions involved in the maturation of tRNAs. Here, it endonucleolytically cleaves the RNA and removes extra 3' nucleotides from the tRNA precursor, generating the 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. Similarly, it processes tRNA-like molecules such as mascRNA. The enzyme does not use a cofactor. (en) リボヌクレアーゼZ(Ribonuclease Z、EC 3.1.26.11)は、以下の化学反応を触媒する酵素である。 リボ核酸をエンド型で切断する。転移RNA前駆体の3'末端についた余計なヌクレオチドを除去し、3'末端を生成する。3'-ヒドロキシ基は転移RNAの末端に残り、5'-ホスホリル基は後ろの分子に残る。 この酵素は、補因子を必要としない。 (ja) 核糖核酸酶Z（Ribonuclease Z、RNase Z、3′ tRNase，在不同生物中的名稱包括ElaC、ZiPD、RNase BN、TRZ1等）是一種參與tRNA生合成的核糖核酸酶，為內切酶，屬鋅依賴型金屬水解酶，編碼此蛋白的基因於2002年被發現。 tRNA基因轉錄產生tRNA前驅物（pre-tRNA）後，其5′端會被核糖核酸酶P切割，3′端則被核糖核酸酶Z切割，隨後再由在其3′端加上CCA三個鹼基，以生成成熟的tRNA。核糖核酸酶Z切割位點下游位點的CC會抑制其切割活性，因此已被加上CCA的成熟tRNA不會再被其切割，此外tRNA前驅物5′端序列的長度也可能影響核糖核酸酶Z切割的活性。 釀酒酵母、大腸桿菌、枯草桿菌、海栖热袍菌等生物的核糖核酸酶Z結構均已被解出。 (zh) |
| rdfs:label | リボヌクレアーゼZ (ja) Ribonuclease Z (en) 核糖核酸酶Z (zh) |
| owl:sameAs | freebase:Ribonuclease Z wikidata:Ribonuclease Z dbpedia-ja:Ribonuclease Z dbpedia-sh:Ribonuclease Z dbpedia-sr:Ribonuclease Z dbpedia-zh:Ribonuclease Z https://global.dbpedia.org/id/AFo8 |
| prov:wasDerivedFrom | wikipedia-en:Ribonuclease_Z?oldid=1044706817&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Ribonuclease_Z |
| foaf:name | TRNase Z (en) |
| is dbo:wikiPageRedirects of | dbr:RNase_Z dbr:3'_tRNase dbr:3_tRNase dbr:EC_3.1.26.11 dbr:TRNA_3_endonuclease |
| is dbo:wikiPageWikiLink of | dbr:Caldibacillus dbr:List_of_EC_numbers_(EC_3) dbr:Gene_expression dbr:Transfer_RNA dbr:RNase_Z dbr:3'_tRNase dbr:3_tRNase dbr:EC_3.1.26.11 dbr:TRNA_3_endonuclease |
| is foaf:primaryTopic of | wikipedia-en:Ribonuclease_Z |