| dbo:abstract |
Ritalinic acid is a substituted phenethylamine and an inactive major metabolite of the psychostimulant drugs methylphenidate and ethylphenidate. When administered orally, methylphenidate is extensively metabolized in the liver by hydrolysis of the ester group yielding ritalinic acid. The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1). Etymologically, ritalinic acid shares its roots with Ritalin, a common brand name for methylphenidate. (en) Ácido ritalínico é uma fenetilamina substituída e um dos principais metabólitos inativos das drogas psicoestimulantes metilfenidato e etilfenidato. Quando administrado por via oral, o metilfenidato é extensamente metabolizado no fígado por hidrólise do grupo éster, originando o ácido ritalínico. A hidrólise é catalisada pela enzima carboxilesterase 1 (CES1). (pt) |
| dbo:casNumber |
19395-41-6 |
| dbo:fdaUniiCode |
GT4165RS9H |
| dbo:pubchem |
86863 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Ritalinic_acid-2D-skeletal.svg?width=300 |
| dbo:wikiPageExternalLink |
https://pubchem.ncbi.nlm.nih.gov/compound/Ritalinic-acid |
| dbo:wikiPageID |
42225661 (xsd:integer) |
| dbo:wikiPageLength |
3372 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1074365899 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Metabolite dbr:PubChem dbr:Ester dbr:Stimulant dbr:Ethylphenidate dbr:Carboxylesterase_1 dbc:2-Benzylpiperidines dbc:Methylphenidate dbr:Isopropylphenidate dbr:Methylphenidate dbr:Substituted_phenethylamine |
| dbp:atcPrefix |
None (en) |
| dbp:c |
13 (xsd:integer) |
| dbp:casNumber |
19395 (xsd:integer) |
| dbp:chemspiderid |
78360 (xsd:integer) |
| dbp:h |
17 (xsd:integer) |
| dbp:iupacName |
Phenylacetic acid (en) |
| dbp:legalUs |
Unscheduled and Uncontrolled (en) |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
86863 (xsd:integer) |
| dbp:smiles |
C1CCNCCCO (en) |
| dbp:stdinchi |
InChI=1S/C13H17NO2/c15-131211-8-4-5-9-14-11/h1-3,6-7,11-12,14H,4-5,8-9H2, (en) |
| dbp:stdinchikey |
INGSNVSERUZOAK-UHFFFAOYSA-N (en) |
| dbp:unii |
GT4165RS9H (en) |
| dbp:verifiedrevid |
464371569 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Fdacite dbt:Stdinchicite |
| dcterms:subject |
dbc:2-Benzylpiperidines dbc:Methylphenidate |
| gold:hypernym |
dbr:Phenethylamine |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:ChemicalCompound dbo:Drug |
| rdfs:comment |
Ritalinic acid is a substituted phenethylamine and an inactive major metabolite of the psychostimulant drugs methylphenidate and ethylphenidate. When administered orally, methylphenidate is extensively metabolized in the liver by hydrolysis of the ester group yielding ritalinic acid. The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1). Etymologically, ritalinic acid shares its roots with Ritalin, a common brand name for methylphenidate. (en) Ácido ritalínico é uma fenetilamina substituída e um dos principais metabólitos inativos das drogas psicoestimulantes metilfenidato e etilfenidato. Quando administrado por via oral, o metilfenidato é extensamente metabolizado no fígado por hidrólise do grupo éster, originando o ácido ritalínico. A hidrólise é catalisada pela enzima carboxilesterase 1 (CES1). (pt) |
| rdfs:label |
Ritalinic acid (en) Ácido ritalínico (pt) |
| owl:sameAs |
freebase:Ritalinic acid wikidata:Ritalinic acid dbpedia-pt:Ritalinic acid https://global.dbpedia.org/id/fwGc |
| prov:wasDerivedFrom |
wikipedia-en:Ritalinic_acid?oldid=1074365899&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Ritalinic_acid-2D-skeletal.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Ritalinic_acid |
| is dbo:wikiPageRedirects of |
dbr:Ritalinate |
| is dbo:wikiPageWikiLink of |
dbr:Rodrigo_Nascimento dbr:José_Belda dbr:C13H17NO2 dbr:List_of_methylphenidate_analogues dbr:UFC_on_ESPN:_Makhachev_vs._Moisés dbr:2021_in_UFC dbr:Alan_Baudot dbr:Ethylphenidate dbr:Hagerstown_Suns dbr:Methylphenidate dbr:Serdexmethylphenidate dbr:Ritalinate |
| is dbp:metabolites of |
dbr:Serdexmethylphenidate |
| is foaf:primaryTopic of |
wikipedia-en:Ritalinic_acid |
