Rudolph E. Tanzi (original) (raw)
Rudolph Tanzi (Rhode Island, 1958) é um médico norte-americano e professor de neurocirurgia na Universidade de Harvard. Em 2015, apareceu na lista de 100 pessoas mais influentes do ano pela Time.
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| dbo:abstract | Rudolph Emile 'Rudy' Tanzi (born September 18, 1958) is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and Co-director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital (MGH). Dr. Tanzi has been investigating the genetics of neurological disease since the 1980s when he participated in the first study that used genetic markers to find a disease gene (Huntington's disease). Dr. Tanzi co-discovered all three familial early-onset Alzheimer's disease (FAD) genes and several other neurological disease genes including that responsible for Wilson’s disease. As the leader of the Cure Alzheimer's Fund Alzheimer’s Genome Project, Dr. Tanzi has carried out multiple genome wide association studies of thousands of Alzheimer’s families leading to the identification of novel AD candidate genes, including CD33 and the first two rare mutations causing late-onset AD in the ADAM10 gene. His research on the role of zinc and copper in AD has led to clinical trials at Prana Biotechnology (now Alterity Therapeutics). He is also working on gamma secretase modulators (together with Dr. Steven Wagner, UCSD) for the prevention and treatment of Alzheimer's. He also serves as Chair of the Cure Alzheimer's Fund Research Leadership Group and Director the Cure Alzheimer’s Fund Alzheimer’s Genome Project™. Dr. Tanzi’s team was the first to use human stem cells to create three-dimensional cell culture organoids of AD, dubbed “Alzheimer’s-in-a-Dish”. This model was the first to recapitulate all three key AD pathological hallmarks in vitro, and first to definitively show that amyloid plaques directly cause neurofibrillary tangles. The 3-D model also made drug screening for AD faster and more cost-effective. Using this system, Dr. Tanzi has developed several novel therapies for AD including gamma secretase modulators targeting amyloid pathology, ALZT-OP1 targeting neuroinflammation and a neuroprotective drug combination, AMX0035, which was successful in a clinical trial of ALS. Dr. Tanzi also discovered that beta-amyloid plays a functional role in the brain as an anti-microbial peptide, supporting a role for infection in AD pathology. Dr. Tanzi serves as Chair of the Cure Alzheimer’s Fund Research Leadership Group and numerous advisory and editorial boards, He has published over 600 research papers and has received the highest awards in his field, including the Metropolitan Life Foundation Award, Potamkin Prize, Ronald Reagan Award, Silver Innovator Award, the Smithsonian American Ingenuity Award, and the Brain Research Foundation Award. In 2015, he was named to TIME magazine’s list of TIME100 Most Influential People in the World. He co-authored the books Decoding Darkness, and the three international bestsellers, Super Brain, Super Genes, and The Healing Self, with Dr. Deepak Chopra. Dr. Tanzi has hosted three shows public television, regularly appears on television news programs, has testified to Congress on both Alzheimer’s disease and brain health, and on occasion serves as a studio keyboard player for Aerosmith, and other musicians. (en) Rudolph Tanzi (Rhode Island, 1958) é um médico norte-americano e professor de neurocirurgia na Universidade de Harvard. Em 2015, apareceu na lista de 100 pessoas mais influentes do ano pela Time. (pt) Рудольф Танзи (родился в 1958 году[уточнить] в Провиденсе, штат Род-Айленд, США) — американский учёный и популяризатор науки. Профессор в Гарвардском университете (The Joseph P. and Rose F. Kennedy Professor of Neurology and Mental Retardation). Руководитель исследовательской группы генетики и старения в Институте нейродегенеративных заболеваний . Специализируется в области изучения молекулярных основ старения, генетики и молекулярной биологии нейродегенеративных заболеваний. Открыл несколько генов, составляющих генетические причины болезни Альцгеймера. Включен в список 100 наиболее влиятельных выпускников Гарвардского университета. Опубликовал несколько книг об исследованиях болезни Альцгеймера. Лауреат нескольких международных научных премий, присуждаемых за исследования по медицине и генетике. В 2012 году в соавторстве с Дипаком Чопрой выпустил книгу «Совершенный мозг». За работы по созданию лабораторной культуры клеток для изучения болезни Альцгеймера включен в список ста наиболее влиятельных людей года Time 100 в 2015 году. (ru) |
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| rdfs:comment | Rudolph Tanzi (Rhode Island, 1958) é um médico norte-americano e professor de neurocirurgia na Universidade de Harvard. Em 2015, apareceu na lista de 100 pessoas mais influentes do ano pela Time. (pt) Rudolph Emile 'Rudy' Tanzi (born September 18, 1958) is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and Co-director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital (MGH). Dr. Tanzi has been investigating the genetics of neurological disease since the 1980s when he participated in the first study that used genetic markers to find a disease gene (Huntington's disease). Dr. Tanzi co-discovered all three familial early-onset Alzheimer's disease (FAD) genes and several other neurological disease genes including that responsible for Wilson’s disease. As the leader of the Cure Alzheimer's Fund Alzheimer’s Genome Project, Dr. Tanzi has carried ou (en) Рудольф Танзи (родился в 1958 году[уточнить] в Провиденсе, штат Род-Айленд, США) — американский учёный и популяризатор науки. Профессор в Гарвардском университете (The Joseph P. and Rose F. Kennedy Professor of Neurology and Mental Retardation). Руководитель исследовательской группы генетики и старения в Институте нейродегенеративных заболеваний . Специализируется в области изучения молекулярных основ старения, генетики и молекулярной биологии нейродегенеративных заболеваний. Открыл несколько генов, составляющих генетические причины болезни Альцгеймера. Включен в список 100 наиболее влиятельных выпускников Гарвардского университета. Опубликовал несколько книг об исследованиях болезни Альцгеймера. Лауреат нескольких международных научных премий, присуждаемых за исследования по медицине и ге (ru) |
| rdfs:label | Rudolph E. Tanzi (en) Rudolph Tanzi (pt) Танзи, Рудольф (ru) |
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