SB-205384 (original) (raw)
SB-205384 is an anxiolytic drug. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. SB-205384 is a GABAA positive allosteric modulator, which binds preferentially to α3, α5, and α6 subunit containing subtypes. It has a novel mechanism of action, prolonging the duration of GABA-mediated chloride flux but without increasing the intensity of the response, and this may give it an unusual pharmacological profile, with tests showing that it alters the firing of some populations of neurons while leaving others unaffected. Animal studies have shown it to produce both anxiolytic and anti-aggressive effects, but with little sedation or other behavioural changes.
| Property | Value |
|---|---|
| dbo:abstract | SB-205384 is an anxiolytic drug. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. SB-205384 is a GABAA positive allosteric modulator, which binds preferentially to α3, α5, and α6 subunit containing subtypes. It has a novel mechanism of action, prolonging the duration of GABA-mediated chloride flux but without increasing the intensity of the response, and this may give it an unusual pharmacological profile, with tests showing that it alters the firing of some populations of neurons while leaving others unaffected. Animal studies have shown it to produce both anxiolytic and anti-aggressive effects, but with little sedation or other behavioural changes. (en) |
| dbo:casNumber | 160296-13-9 |
| dbo:pubchem | 197690 |
| dbo:thumbnail | wiki-commons:Special:FilePath/SB-205384.png?width=300 |
| dbo:wikiPageID | 18456598 (xsd:integer) |
| dbo:wikiPageLength | 4737 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 983334606 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Benzodiazepine dbc:Alkyne_derivatives dbc:Carboxylate_esters dbc:GABAA_receptor_positive_allosteric_modulators dbc:Secondary_alcohols dbr:Anxiolytic dbr:Positive_allosteric_modulator dbr:GABAA_receptor dbc:Anxiolytics dbr:Nonbenzodiazepine |
| dbp:c | 17 (xsd:integer) |
| dbp:casNumber | 160296 (xsd:integer) |
| dbp:chemspiderid | 171116 (xsd:integer) |
| dbp:h | 18 (xsd:integer) |
| dbp:iupacName | But-2-ynyl 4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyridine-3-carboxylate (en) |
| dbp:legalUs | Investigational New Drug (en) |
| dbp:n | 2 (xsd:integer) |
| dbp:o | 3 (xsd:integer) |
| dbp:pubchem | 197690 (xsd:integer) |
| dbp:s | 1 (xsd:integer) |
| dbp:smiles | CC#CCOCc1cnc2sc3CCCCc3c2c1N (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | JDTZAGLGBRRCJT-UHFFFAOYSA-N (en) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 399126895 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:width | 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:GABAAR_PAMs dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Stdinchicite dbt:Anxiolytics dbt:Anxiolytic-stub |
| dct:subject | dbc:Alkyne_derivatives dbc:Carboxylate_esters dbc:GABAA_receptor_positive_allosteric_modulators dbc:Secondary_alcohols dbc:Anxiolytics |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | SB-205384 is an anxiolytic drug. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. SB-205384 is a GABAA positive allosteric modulator, which binds preferentially to α3, α5, and α6 subunit containing subtypes. It has a novel mechanism of action, prolonging the duration of GABA-mediated chloride flux but without increasing the intensity of the response, and this may give it an unusual pharmacological profile, with tests showing that it alters the firing of some populations of neurons while leaving others unaffected. Animal studies have shown it to produce both anxiolytic and anti-aggressive effects, but with little sedation or other behavioural changes. (en) |
| rdfs:label | SB-205384 (en) |
| owl:sameAs | wikidata:SB-205384 dbpedia-sh:SB-205384 dbpedia-sr:SB-205384 https://global.dbpedia.org/id/4v3U6 |
| prov:wasDerivedFrom | wikipedia-en:SB-205384?oldid=983334606&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/SB-205384.png |
| foaf:isPrimaryTopicOf | wikipedia-en:SB-205384 |
| is dbo:wikiPageRedirects of | dbr:SB-205,384 |
| is dbo:wikiPageWikiLink of | dbr:C17H18N2O3S dbr:SB-205,384 |
| is foaf:primaryTopic of | wikipedia-en:SB-205384 |
