SB-649,915 (original) (raw)
SB-649,915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist which is being investigated for its antidepressant effects. Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well. This can be attributed to blockade of 5-HT1A and 5-HT1B autoreceptors which inhibit serotonin release.
| Property | Value |
|---|---|
| dbo:abstract | SB-649,915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist which is being investigated for its antidepressant effects. Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well. This can be attributed to blockade of 5-HT1A and 5-HT1B autoreceptors which inhibit serotonin release. (en) SB-649,915 — это СИОЗС и одновременно антагонист серотониновых рецепторов подтипов 5-HT1A и , который исследуется в качестве потенциального антидепрессанта. По сравнению с существующими СИОЗС, SB-649,915 имеет более быстрое начало антидепрессивного действия, а также может иметь более высокую клиническую эффективность. Это приписывают блокаде им пресинаптических ауторегуляторных 5-HT1A и 5-HT1B-рецепторов, которые угнетают выброс серотонина. (ru) |
| dbo:casNumber | 420785-70-2 |
| dbo:chEMBL | 183460 |
| dbo:fdaUniiCode | HD3UV2MFJ8 |
| dbo:pubchem | 10225553 |
| dbo:thumbnail | wiki-commons:Special:FilePath/SB-649,915_structure.png?width=300 |
| dbo:wikiPageID | 23142317 (xsd:integer) |
| dbo:wikiPageLength | 2812 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1124442044 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Onset_of_action dbc:Benzoxazines dbc:Lactams dbc:Phenol_ethers dbc:Piperidines dbr:Elzasonan dbr:Antidepressant dbr:Receptor_antagonist dbr:Autoreceptor dbc:5-HT1_antagonists dbr:5-HT1A_receptor dbr:5-HT1B_receptor dbc:Quinolines dbc:Selective_serotonin_reuptake_inhibitors dbr:LY-367,265 dbr:Selective_serotonin_reuptake_inhibitor dbr:Serotonin dbr:Serotonin_reuptake_inhibitor |
| dbp:atcPrefix | none (en) |
| dbp:c | 26 (xsd:integer) |
| dbp:casNumber | 420785 (xsd:integer) |
| dbp:chembl | 183460 (xsd:integer) |
| dbp:chemspiderid | 8471882 (xsd:integer) |
| dbp:h | 29 (xsd:integer) |
| dbp:iupacName | 6 (xsd:integer) |
| dbp:iupharLigand | 76 (xsd:integer) |
| dbp:legalStatus | Uncontrolled (en) |
| dbp:n | 3 (xsd:integer) |
| dbp:o | 3 (xsd:integer) |
| dbp:pubchem | 10225553 (xsd:integer) |
| dbp:smiles | O=C4COc1cccCCCCN5CCOcc2ccc3C (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | PJSUYRBCBFPCQW-UHFFFAOYSA-N (en) |
| dbp:unii | HD3UV2MFJ8 (en) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 417826089 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Reflist dbt:Serotonin_receptor_modulators dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Antidepressants dbt:Anxiolytics dbt:Monoamine_reuptake_inhibitors |
| dcterms:subject | dbc:Benzoxazines dbc:Lactams dbc:Phenol_ethers dbc:Piperidines dbc:5-HT1_antagonists dbc:Quinolines dbc:Selective_serotonin_reuptake_inhibitors |
| gold:hypernym | dbr:Inhibitor |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Adversary109773245 yago:CausalAgent100007347 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:YagoLegalActor yago:YagoLegalActorGeo dbo:Drug yago:Whole100003553 yago:Wikicat5-HT1Antagonists |
| rdfs:comment | SB-649,915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist which is being investigated for its antidepressant effects. Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well. This can be attributed to blockade of 5-HT1A and 5-HT1B autoreceptors which inhibit serotonin release. (en) SB-649,915 — это СИОЗС и одновременно антагонист серотониновых рецепторов подтипов 5-HT1A и , который исследуется в качестве потенциального антидепрессанта. По сравнению с существующими СИОЗС, SB-649,915 имеет более быстрое начало антидепрессивного действия, а также может иметь более высокую клиническую эффективность. Это приписывают блокаде им пресинаптических ауторегуляторных 5-HT1A и 5-HT1B-рецепторов, которые угнетают выброс серотонина. (ru) |
| rdfs:label | SB-649,915 (en) SB-649,915 (ru) |
| owl:sameAs | freebase:SB-649,915 yago-res:SB-649,915 wikidata:SB-649,915 dbpedia-ru:SB-649,915 dbpedia-sh:SB-649,915 dbpedia-sr:SB-649,915 https://global.dbpedia.org/id/JpAs |
| prov:wasDerivedFrom | wikipedia-en:SB-649,915?oldid=1124442044&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/SB-649,915_structure.png |
| foaf:isPrimaryTopicOf | wikipedia-en:SB-649,915 |
| is dbo:wikiPageRedirects of | dbr:SB-649915 |
| is dbo:wikiPageWikiLink of | dbr:Elzasonan dbr:Zimelidine dbr:5-HT1A_receptor dbr:Serotonin_reuptake_inhibitor dbr:SB-649915 |
| is foaf:primaryTopic of | wikipedia-en:SB-649,915 |
