SC-8109 (original) (raw)
SC-8109 is a steroidal antimineralocorticoid of the spirolactone group which was never marketed. It is a potent antagonist of the mineralocorticoid receptor and is more potent than the related drug SC-5233 (of which SC-8109 is the 19-nor analogue). However, SC-8109 was found to have relatively low oral bioavailability and potency, though it nonetheless produced a mild diuretic effect in patients with congestive heart failure. Spironolactone (SC-9420; Aldactone), another spirolactone, followed and had both good oral bioavailability and potency, and was the first antimineralocorticoid to be marketed.
| Property | Value |
|---|---|
| dbo:abstract | SC-8109 is a steroidal antimineralocorticoid of the spirolactone group which was never marketed. It is a potent antagonist of the mineralocorticoid receptor and is more potent than the related drug SC-5233 (of which SC-8109 is the 19-nor analogue). However, SC-8109 was found to have relatively low oral bioavailability and potency, though it nonetheless produced a mild diuretic effect in patients with congestive heart failure. Spironolactone (SC-9420; Aldactone), another spirolactone, followed and had both good oral bioavailability and potency, and was the first antimineralocorticoid to be marketed. In addition to its antimineralocorticoid activity, SC-8109 shows potent progestogenic activity, with similar potency relative to that of progesterone. Its analogue, SC-5233, possesses similar but less potent progestogenic activity. In addition, SC-5233 has been assessed and found to possess some antiandrogenic activity, antagonizing the effects of testosterone in animals, and SC-8109 may as well. (en) |
| dbo:casNumber | 1722-54-9 |
| dbo:pubchem | 168943 |
| dbo:thumbnail | wiki-commons:Special:FilePath/SC-8109.svg?width=300 |
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| dbo:wikiPageWikiLink | dbr:Canrenone dbr:Potency_(pharmacology) dbr:Progesterone_(medication) dbr:Progestogen dbr:Antimineralocorticoid dbr:Ligand_(biochemistry) dbc:Antimineralocorticoids dbc:Lactones dbc:Progestogens dbc:Spiro_compounds dbr:Congestive_heart_failure dbr:SC-5233 dbr:Oral_administration dbc:Norpregnanes dbr:Antiandrogen dbr:Steroid dbr:Structural_analogue dbr:Receptor_antagonist dbc:Diuretics dbc:Spirolactones dbr:Diuretic dbr:Aldosterone dbr:Estradiol_(medication) dbr:Testosterone dbr:Testosterone_(medication) dbr:Bioavailability dbr:Spironolactone dbr:Mineralocorticoid_receptor dbr:Spirolactone |
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| dbp:casNumber | 1722 (xsd:integer) |
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| dbp:iupacName | -120.0 (dbd:second) |
| dbp:o | 3 (xsd:integer) |
| dbp:pubchem | 168943 (xsd:integer) |
| dbp:smiles | C[C@]12CC[C@H]3[C@H]CCC5=CCCC[C@H]35 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | CXXAIOQMCGJVHT-XUJOMZSTSA-N (en) |
| dbp:synonyms | 19 (xsd:integer) |
| dbp:width | 225 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Mineralocorticoid_receptor_modulators dbt:Progesterone_receptor_modulators dbt:Reflist dbt:Steroid-stub dbt:Abbrlink |
| dct:subject | dbc:Antimineralocorticoids dbc:Lactones dbc:Progestogens dbc:Spiro_compounds dbc:Norpregnanes dbc:Diuretics dbc:Spirolactones |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | SC-8109 is a steroidal antimineralocorticoid of the spirolactone group which was never marketed. It is a potent antagonist of the mineralocorticoid receptor and is more potent than the related drug SC-5233 (of which SC-8109 is the 19-nor analogue). However, SC-8109 was found to have relatively low oral bioavailability and potency, though it nonetheless produced a mild diuretic effect in patients with congestive heart failure. Spironolactone (SC-9420; Aldactone), another spirolactone, followed and had both good oral bioavailability and potency, and was the first antimineralocorticoid to be marketed. (en) |
| rdfs:label | SC-8109 (en) |
| owl:sameAs | wikidata:SC-8109 https://global.dbpedia.org/id/2dBfC yago-res:SC-8109 |
| prov:wasDerivedFrom | wikipedia-en:SC-8109?oldid=995121736&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/SC-8109.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:SC-8109 |
| is dbo:wikiPageRedirects of | dbr:SC8109 dbr:SC_8109 |
| is dbo:wikiPageWikiLink of | dbr:C21H28O3 dbr:SC-5233 dbr:Spironolactone dbr:List_of_steroidal_antiandrogens dbr:Spirolactone dbr:SC8109 dbr:SC_8109 |
| is foaf:primaryTopic of | wikipedia-en:SC-8109 |
