SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine. SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen.
| Property |
Value |
| dbo:abstract |
SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine. SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen. (en) |
| dbo:casNumber |
80751-65-1 |
| dbo:chEMBL |
317741 |
| dbo:fdaUniiCode |
7W60FE897Q |
| dbo:pubchem |
1225 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/SKF_82958.png?width=300 |
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3848593 (xsd:integer) |
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6650 (xsd:nonNegativeInteger) |
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dbr:Benzazepine dbr:Anorectic dbc:D5_receptor_agonists dbr:Dopaminergic dbc:Allyl_compounds dbc:Chloroarenes dbc:GSK_plc_brands dbc:Phenols dbc:Synthetic_estrogens dbr:SKF-81,297 dbr:Chemical_compound dbr:Chemical_synthesis dbr:Estrogen dbr:Full_agonist dbr:Stimulant dbc:1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines dbc:D1-receptor_agonists dbr:6-Br-APB dbr:Agonist dbr:Amphetamine dbr:D1_receptor dbr:D5_receptor dbr:Hyperactivity dbr:Self-administration dbr:Chemical_class dbr:ERα dbr:ERβ |
| dbp:c |
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| dbp:casNumber |
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| dbp:chembl |
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| dbp:chemspiderid |
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| dbp:cl |
1 (xsd:integer) |
| dbp:h |
20 (xsd:integer) |
| dbp:iupacName |
3 (xsd:integer) |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
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| dbp:smiles |
C=CCN1CCC2=CCl (en) |
| dbp:unii |
7 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Gastrointestinal-drug-stub dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Reflist dbt:Short_description dbt:Stimulants dbt:Fdacite dbt:Dopamine_receptor_modulators dbt:Anorectics |
| dcterms:subject |
dbc:D5_receptor_agonists dbc:Allyl_compounds dbc:Chloroarenes dbc:GSK_plc_brands dbc:Phenols dbc:Synthetic_estrogens dbc:1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines dbc:D1-receptor_agonists |
| gold:hypernym |
dbr:Compound |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Alkene114713120 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Statement106722453 yago:Substance100019613 yago:WikicatAlkenes yago:WikicatPhenols |
| rdfs:comment |
SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine. SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen. (en) |
| rdfs:label |
SKF-82,958 (en) |
| owl:sameAs |
freebase:SKF-82,958 yago-res:SKF-82,958 wikidata:SKF-82,958 dbpedia-sh:SKF-82,958 dbpedia-sr:SKF-82,958 https://global.dbpedia.org/id/Jeow |
| prov:wasDerivedFrom |
wikipedia-en:SKF-82,958?oldid=1115659615&ns=0 |
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wiki-commons:Special:FilePath/SKF_82958.png |
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wikipedia-en:SKF-82,958 |
| is dbo:wikiPageRedirects of |
dbr:C19H20ClNO2 dbr:SKF-82958 dbr:SKF_82958 |
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dbr:List_of_dopaminergic_drugs dbr:SKF-81,297 dbr:C19H20ClNO2 dbr:6-Br-APB dbr:A-77636 dbr:Estrogen_receptor_alpha dbr:SKF-82958 dbr:SKF_82958 |
| is foaf:primaryTopic of |
wikipedia-en:SKF-82,958 |
