SYM-2081 (original) (raw)
SYM-2081 is a highly selective agonist for the kainate receptor. This potent agonist has nearly 3,000 fold- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors, respectively. Given its potency and selectivity, it is a useful ligand for studying the role of kainate receptors in the central nervous system.
| Property | Value |
|---|---|
| dbo:abstract | SYM-2081 is a highly selective agonist for the kainate receptor. This potent agonist has nearly 3,000 fold- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors, respectively. Given its potency and selectivity, it is a useful ligand for studying the role of kainate receptors in the central nervous system. (en) (2S,4R)-4-метилглутамінова кислота ((2S,4R)-4-Methylglutamic acid, SYM2081) — сильний та високоселективний агоніст каїнатних рецепторів, з меншою активністю на АМРА- та NMDA-рецепторах. Окрім того, у високих концентраціях здатний інгібіювати роботу транспортера збуджуючих амінокислот . (uk) |
| dbo:alternativeName | (2S,4R)-4-Methylglutamic acid (en) |
| dbo:iupacName | (2S,4R)-2-Amino-4-methylpentanedioic acid (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/SYM2081.svg?width=300 |
| dbo:wikiPageID | 69527981 (xsd:integer) |
| dbo:wikiPageLength | 4443 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1117829640 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Aqueous_solution dbr:Lithium_bis(trimethylsilyl)amide dbr:Lithium_hydroxide dbc:Dicarboxylic_acids dbr:Column_chromatography dbr:Trifluoroacetic_acid dbr:Agonist dbr:Central_nervous_system dbr:Kainate_receptor dbr:Redox dbc:Amino_acid_derivatives dbr:Iodomethane dbr:Tetra-n-butylammonium_fluoride dbr:Tetrahydrofuran dbr:AMPA_receptor dbr:Dichloromethane dbr:Tert-Butyldiphenylsilyl dbr:NMDA_receptor dbr:Kainate_receptors |
| dbp:imagefile | SYM2081.svg (en) |
| dbp:imagesize | 200 (xsd:integer) |
| dbp:iupacname | -2 (xsd:integer) |
| dbp:othernames | -4 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist |
| dct:subject | dbc:Dicarboxylic_acids dbc:Amino_acid_derivatives |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | SYM-2081 is a highly selective agonist for the kainate receptor. This potent agonist has nearly 3,000 fold- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors, respectively. Given its potency and selectivity, it is a useful ligand for studying the role of kainate receptors in the central nervous system. (en) (2S,4R)-4-метилглутамінова кислота ((2S,4R)-4-Methylglutamic acid, SYM2081) — сильний та високоселективний агоніст каїнатних рецепторів, з меншою активністю на АМРА- та NMDA-рецепторах. Окрім того, у високих концентраціях здатний інгібіювати роботу транспортера збуджуючих амінокислот . (uk) |
| rdfs:label | SYM-2081 (en) SYM2081 (uk) |
| owl:sameAs | wikidata:SYM-2081 dbpedia-uk:SYM-2081 https://global.dbpedia.org/id/Fok1 |
| prov:wasDerivedFrom | wikipedia-en:SYM-2081?oldid=1117829640&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/SYM2081.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:SYM-2081 |
| is dbo:wikiPageWikiLink of | dbr:C6H11NO4 dbr:Kainate_receptor |
| is foaf:primaryTopic of | wikipedia-en:SYM-2081 |
