Salinosporamide (original) (raw)

The salinosporamides are a group of closely related chemical compounds isolated from marine bacteria in the genus Salinispora. They possess a densely functionalized γ-lactam-β-lactone bicyclic core. Salinosporamide A has attracted interest for its potential use in treating various types of cancer. In addition, a variety of synthetic analogs have been prepared.