| dbo:abstract |
Sarecycline is a narrow-spectrum tetracycline-derived antibiotic. It is specifically designed for the treatment of acne, and was approved by the FDA in October 2018 for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older. Two randomized and well-controlled clinical trials reported efficacy data on both facial and truncal acne (back and chest). Efficacy was assessed in a total of 2002 subjects 9 years of age and older. Unlike other tetracycline-class antibiotics, sarecycline has a long C7 moiety that extends into and directly interact with the bacterial messenger RNA (mRNA). The spectrum of activity is limited to clinically relevant Gram-positive bacteria, mainly Cutibacterium acnes, with little or no activity against Gram-negative bacterial microflora commonly found in the human gastrointestinal tract. Sarecycline has not been tested in spirochetes. (en) Сарециклин — антибиотик группы тетрациклинов узкого спектра действия для лечения акне. Одобрен для применения: США (2018). (ru) |
| dbo:alternativeName |
Seysara (en) |
| dbo:casNumber |
1035654-66-0 |
| dbo:chEMBL |
2364632 |
| dbo:drugbank |
DB12035 DBSALT002125 |
| dbo:fdaUniiCode |
94O110CX2E |
| dbo:kegg |
D10666 D10667 |
| dbo:medlinePlus |
a618068 |
| dbo:pubchem |
54681908 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Sarecycline.svg?width=300 |
| dbo:wikiPageExternalLink |
https://druginfo.nlm.nih.gov/drugportal/name/sarecycline |
| dbo:wikiPageID |
50224320 (xsd:integer) |
| dbo:wikiPageLength |
6157 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1090379538 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Messenger_RNA dbr:Cutibacterium_acnes dbc:Tetracycline_antibiotics dbr:Acne_vulgaris dbr:Gram-negative_bacteria dbr:Gram-positive_bacteria dbr:Tetracycline dbr:Spirochaete dbr:Microbiota dbr:Narrow-spectrum_antibiotic dbr:methoxy(methyl)amino]methyl]-...ahydro-4''H''-tetracene-2-carboxamide |
| dbp:atcPrefix |
J01 (en) |
| dbp:atcSuffix |
AA14 (en) |
| dbp:c |
24 (xsd:integer) |
| dbp:casNumber |
1035654 (xsd:integer) |
| dbp:chembl |
2364632 (xsd:integer) |
| dbp:chemspiderid |
28540486 (xsd:integer) |
| dbp:dailymedid |
Sarecycline (en) |
| dbp:drugbank |
DB12035 (en) DBSALT002125 (en) |
| dbp:h |
29 (xsd:integer) |
| dbp:index2Label |
as HCl (en) |
| dbp:iupacName |
-4 (xsd:integer) |
| dbp:kegg |
D10666 (en) D10667 (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:medlineplus |
a618068 (en) |
| dbp:n |
3 (xsd:integer) |
| dbp:o |
8 (xsd:integer) |
| dbp:pdbLigand |
V7A (en) |
| dbp:pronounce |
sar"e sye' kleen (en) |
| dbp:pubchem |
54681908 (xsd:integer) 71296095 (xsd:integer) |
| dbp:smiles |
CN[C@H]1[C@@H]2C[C@@H]3CC4=CCNOC (en) |
| dbp:synonyms |
P-005672 (en) |
| dbp:tradename |
Seysara (en) |
| dbp:unii |
94 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Cite_web dbt:Infobox_drug dbt:Portal_bar dbt:Reflist dbt:ATC dbt:Drugs.com dbt:Protein_synthesis_inhibitor_antibiotics dbt:Antiinfective-drug-stub |
| dct:subject |
dbc:Tetracycline_antibiotics |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment |
Сарециклин — антибиотик группы тетрациклинов узкого спектра действия для лечения акне. Одобрен для применения: США (2018). (ru) Sarecycline is a narrow-spectrum tetracycline-derived antibiotic. It is specifically designed for the treatment of acne, and was approved by the FDA in October 2018 for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older. Two randomized and well-controlled clinical trials reported efficacy data on both facial and truncal acne (back and chest). Efficacy was assessed in a total of 2002 subjects 9 years of age and older. Unlike other tetracycline-class antibiotics, sarecycline has a long C7 moiety that extends into and directly interact with the bacterial messenger RNA (mRNA). The spectrum of activity is limited to clinically relevant Gram-positive bacteria, mainly Cutibacterium acnes, with little or no activity against Gr (en) |
| rdfs:label |
Sarecycline (en) Сарециклин (ru) |
| owl:sameAs |
yago-res:Sarecycline wikidata:Sarecycline dbpedia-fa:Sarecycline dbpedia-ru:Sarecycline https://global.dbpedia.org/id/2NAPQ |
| prov:wasDerivedFrom |
wikipedia-en:Sarecycline?oldid=1090379538&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Sarecycline.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Sarecycline |
| is dbo:wikiPageRedirects of |
dbr:Sarecycline_HCl dbr:Sarecycline_hydrochloride dbr:Seysara |
| is dbo:wikiPageWikiLink of |
dbr:Antimicrobial_spectrum dbr:Sarecycline_HCl dbr:Sarecycline_hydrochloride dbr:Broad-spectrum_antibiotic dbr:ATC_code_J01 dbr:Acne dbr:Tetracycline_antibiotics dbr:Omadacycline dbr:Narrow-spectrum_antibiotic dbr:Seysara |
| is foaf:primaryTopic of |
wikipedia-en:Sarecycline |
