Sema domain (original) (raw)
The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor (Uniprot: P08581), Plexin-A3 (Uniprot: P51805) and in viral proteins. CD100 (also called SEMA4D) is associated with and serine kinase activity. CD100 increases PMA, CD3 and CD2 induced T cell proliferation, increases CD45 induced T cell adhesion, induces B cell homotypic adhesion and down-regulates B cell expression of CD23.
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| dbo:abstract | The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor (Uniprot: P08581), Plexin-A3 (Uniprot: P51805) and in viral proteins. CD100 (also called SEMA4D) is associated with and serine kinase activity. CD100 increases PMA, CD3 and CD2 induced T cell proliferation, increases CD45 induced T cell adhesion, induces B cell homotypic adhesion and down-regulates B cell expression of CD23. The Sema domain is characterised by a conserved set of cysteine residues, which form four disulfide bonds to stabilise the structure. The Sema domain fold is a variation of the beta propeller topology, with seven blades radiallyarranged around a central axis. Each blade contains a four- stranded (strands A to D) antiparallel beta sheet. The inner strand of each blade (A) lines the channel at the centre of the propeller, with strands B and C of the same repeat radiating outward, and strand D of the next repeat forming the outer edge of the blade. The large size of the Sema domain is not due to a single inserted domain but results from the presence of additional secondary structure elements inserted in most of the blades. The Sema domain uses a 'loop and hook' system to close the circle between the first and the last blades. The blades are constructed sequentially with an N-terminal beta- strand closing the circle by providing the outermost strand (D) of the seventh (C-terminal) blade. The beta-propeller is further stabilized by an extension of the N-terminus, providing an additional, fifth beta-strand on the outer edge of blade 6. (en) |
| dbo:symbol | Sema |
| dbo:thumbnail | wiki-commons:Special:FilePath/PBB_Protein_SEMA3A_image.jpg?width=300 |
| dbo:wikiPageID | 14693740 (xsd:integer) |
| dbo:wikiPageLength | 4432 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1032323066 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:MST1R dbr:PLXNB2 dbr:SEMA3C dbr:SEMA3F dbc:Protein_families dbr:SEMA3A dbr:SEMA4A dbr:SEMA4D dbr:PLXNA2 dbr:Protein_family dbc:Protein_domains dbr:B_cell dbr:SEMA4C dbc:Single-pass_transmembrane_proteins dbr:SEMA6A dbr:Axon_guidance dbr:C-Met dbr:CD23 dbr:SEMA4B dbr:Semaphorin dbr:SEMA7A dbr:SEMA6C dbr:SEMA3B dbr:PLXNB3 dbr:SEMA4F dbr:SEMA5A dbr:PLXND1 dbr:PLXNA3 dbr:SEMA4G dbr:PLXNB1 dbr:PLXNA1 dbr:Serine_kinase dbr:Structural_domain dbr:SEMA3E dbr:PTPase dbr:SEMA3D dbr:SEMA3G dbr:SEMA5B dbr:SEMA6B dbr:SEMA6D dbr:PLXNA4 |
| dbp:caption | Sema domain, immunoglobulin domain , short basic domain (en) |
| dbp:interpro | IPR001627 (en) |
| dbp:membranomeSuperfamily | 71 (xsd:integer) |
| dbp:pfam | PF01403 (en) |
| dbp:prosite | PDOC51004 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | Sema (en) |
| dbp:width | 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:InterPro_content dbt:Reflist dbt:Uniprot dbt:Pfam_box |
| dcterms:subject | dbc:Protein_families dbc:Protein_domains dbc:Single-pass_transmembrane_proteins |
| gold:hypernym | dbr:Domain |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatSingle-passTransmembraneProteins yago:Abstraction100002137 yago:Attribute100024264 yago:Chemical114806838 yago:Compound114818238 yago:Environment113934596 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Protein yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteinDomains |
| rdfs:comment | The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor (Uniprot: P08581), Plexin-A3 (Uniprot: P51805) and in viral proteins. CD100 (also called SEMA4D) is associated with and serine kinase activity. CD100 increases PMA, CD3 and CD2 induced T cell proliferation, increases CD45 induced T cell adhesion, induces B cell homotypic adhesion and down-regulates B cell expression of CD23. (en) |
| rdfs:label | Sema domain (en) |
| owl:sameAs | freebase:Sema domain yago-res:Sema domain wikidata:Sema domain https://global.dbpedia.org/id/2L85C |
| prov:wasDerivedFrom | wikipedia-en:Sema_domain?oldid=1032323066&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PBB_Protein_SEMA3A_image.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Sema_domain |
| is dbo:wikiPageDisambiguates of | dbr:Sema_(disambiguation) |
| is dbo:wikiPageWikiLink of | dbr:Plexin dbr:Sema_(disambiguation) dbr:Semaphorin dbr:Semaphorin-3A |
| is foaf:primaryTopic of | wikipedia-en:Sema_domain |
