Serine hydroxymethyltransferase (original) (raw)
Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an important role in cellular one-carbon pathways by catalyzing the reversible, simultaneous conversions of L-serine to glycine and tetrahydrofolate (THF) to 5,10-Methylenetetrahydrofolate (5,10-CH2-THF). This reaction provides the largest part of the one-carbon units available to the cell.
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| dbo:abstract | Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an important role in cellular one-carbon pathways by catalyzing the reversible, simultaneous conversions of L-serine to glycine and tetrahydrofolate (THF) to 5,10-Methylenetetrahydrofolate (5,10-CH2-THF). This reaction provides the largest part of the one-carbon units available to the cell. (en) La sérine hydroxyméthyltransférase (SHMT) est une transférase qui catalyse la réaction : 5,10-méthylènetétrahydrofolate + glycine + H2O tétrahydrofolate + L-sérine. Cette enzyme joue un rôle important dans les voies métaboliques des composés à un seul atome de carbone en catalysant la conversion simultanée et réversible de la L-sérine en glycine et du tétrahydrofolate en 5,10-méthylènetétrahydrofolate. Cette réaction fournit la plus grande partie des unités monocarbonées pour les biosynthèses de la cellule. Des bactéries telles qu’Escherichia coli et Bacillus stearothermophilus possèdent leur propre version de cette enzyme et il apparaît y avoir deux isoformes de sérine hydroxyméthyltransférase chez les mammifères, l'une dans le cytoplasme (cSHMT) et l'autre dans les mitochondries (mSHMT). Les plantes posséderaient également une isoforme particulière dans les chloroplastes. Chez les mammifères, l'enzyme est un tétramère de sous-unités identiques d'environ 50 kDa chacune. L'holoenzyme a par conséquent une masse moléculaire d'environ 200 kDa et incorpore quatre molécules de phosphate de pyridoxal (vitamine B6) comme coenzyme. (fr) セリンヒドロキシメチルトランスフェラーゼ（Serine hydroxymethyltransferase）は、可逆的に同時にL-セリンをグリシンに変換し、テトラヒドロ葉酸を5,10-メチレンテトラヒドロ葉酸に変換する反応を触媒する酵素(EC 2.1.2.1)であり、一炭素基の代謝を行う細胞内での重要な役割を演じている。 グリシンヒドロキシメチルトランスフェラーゼ（glycine hydroxymethyltransferase）とも呼ばれる。 （反応式） テトラヒドロ葉酸 + L-セリン = 5,10-メチレンテトラヒドロ葉酸+ グリシン + H2O (ja) La glicina idrossimetiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: 5,10-metilenetetraidrofolato + glicina + H2O ⇄ tetraidrofolato + L-serina Questo enzima è una proteina che richiede come coenzima il piridossal-fosfato. Catalizza anche la reazione della glicina con acetaldeide per formare L-treonina, e con 4-trimetilammoniobutanale per formare 3-idrossi-N6,N6,N6-trimetil-L-lisina. Dal punto di vista biochimico è notevole l'importanza dell'equilibrio letto da dx a sx poiché costituisce la via più comune di introduzione di una unità monocarboniosa nel tetraidrofolato, per tale motivo l'enzima è più noto come serina idrossimetiltransferasi (SHMT). (it) |
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| dbp:caption | Serine hydroxymethyltransferase 1 , homotetramer, Human (en) |
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| dct:subject | dbc:EC_2.1.2 |
| gold:hypernym | dbr:Enzyme |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 dbo:Enzyme dbo:Protein |
| rdfs:comment | Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an important role in cellular one-carbon pathways by catalyzing the reversible, simultaneous conversions of L-serine to glycine and tetrahydrofolate (THF) to 5,10-Methylenetetrahydrofolate (5,10-CH2-THF). This reaction provides the largest part of the one-carbon units available to the cell. (en) セリンヒドロキシメチルトランスフェラーゼ（Serine hydroxymethyltransferase）は、可逆的に同時にL-セリンをグリシンに変換し、テトラヒドロ葉酸を5,10-メチレンテトラヒドロ葉酸に変換する反応を触媒する酵素(EC 2.1.2.1)であり、一炭素基の代謝を行う細胞内での重要な役割を演じている。 グリシンヒドロキシメチルトランスフェラーゼ（glycine hydroxymethyltransferase）とも呼ばれる。 （反応式） テトラヒドロ葉酸 + L-セリン = 5,10-メチレンテトラヒドロ葉酸+ グリシン + H2O (ja) La glicina idrossimetiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: 5,10-metilenetetraidrofolato + glicina + H2O ⇄ tetraidrofolato + L-serina Questo enzima è una proteina che richiede come coenzima il piridossal-fosfato. Catalizza anche la reazione della glicina con acetaldeide per formare L-treonina, e con 4-trimetilammoniobutanale per formare 3-idrossi-N6,N6,N6-trimetil-L-lisina. Dal punto di vista biochimico è notevole l'importanza dell'equilibrio letto da dx a sx poiché costituisce la via più comune di introduzione di una unità monocarboniosa nel tetraidrofolato, per tale motivo l'enzima è più noto come serina idrossimetiltransferasi (SHMT). (it) La sérine hydroxyméthyltransférase (SHMT) est une transférase qui catalyse la réaction : 5,10-méthylènetétrahydrofolate + glycine + H2O tétrahydrofolate + L-sérine. Cette enzyme joue un rôle important dans les voies métaboliques des composés à un seul atome de carbone en catalysant la conversion simultanée et réversible de la L-sérine en glycine et du tétrahydrofolate en 5,10-méthylènetétrahydrofolate. Cette réaction fournit la plus grande partie des unités monocarbonées pour les biosynthèses de la cellule. (fr) |
| rdfs:label | Sérine hydroxyméthyltransférase (fr) Glicina idrossimetiltransferasi (it) セリンヒドロキシメチルトランスフェラーゼ (ja) Serine hydroxymethyltransferase (en) Serina hidroximetiltransferase (pt) |
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