| dbo:abstract |
Signalpeptidasen, auch Signalasen, sind proteinspaltende Enzyme (Proteasen), die an der Membran des Endoplasmatischen Retikulums (ER) innerhalb der Zelle lokalisiert sind. Die Signalpeptidase erkennt spezielle Aminosäuresequenzen (Signalsequenzen) innerhalb eines Proteins. Sie spaltet im Lumen des ER das Signalpeptid von der restlichen Polypeptidkette ab. (de) In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins. It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). Its sequences is highly conserved in different vertebrate species. SPP cleaves remnant signal peptides left behind in membrane by the action of signal peptidase and also plays key roles in immune surveillance and the maturation of certain viral proteins. (en) |
| dbo:symbol |
Peptidase_A24 Peptidase_A22B |
| dbo:wikiPageExternalLink |
http://merops.sanger.ac.uk/cgi-bin/merops.cgi%3Fid=A22.003 http://merops.sanger.ac.uk/cgi-bin/merops.cgi%3Fid=A22.004 http://merops.sanger.ac.uk/cgi-bin/merops.cgi%3Fid=A22.005 http://merops.sanger.ac.uk/cgi-bin/merops.cgi%3Fid=A22.006 http://merops.sanger.ac.uk/cgi-bin/merops.cgi%3Fid=A22.007 |
| dbo:wikiPageID |
6321288 (xsd:integer) |
| dbo:wikiPageLength |
8776 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1028761806 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Presenilin dbr:Pseudomonas dbr:MHC_class_I dbr:Methylation dbr:Dendritic_cells dbr:Peptide dbr:Intramembrane_protease dbr:Viral_protein dbr:Signal_peptide dbr:Gene_expression dbr:Proteolysis dbr:Enzymes dbr:SPPL2A dbr:Proteolytic dbr:MEROPS dbr:Pathogen dbr:Post-translational_modification dbr:Protein_subunit dbc:Integral_membrane_proteins dbr:Translation_(genetics) dbr:Tumor_necrosis_factor-alpha dbr:Amino_acid dbr:Amino_acids dbr:Extracellular dbr:Protein dbr:Residue_(chemistry) dbr:Transplant_rejection dbr:Hepatitis_C dbr:SPPL2B dbc:Hydrolases dbc:Proteases dbc:EC_3.4.23 dbr:Leader_peptidase_A dbr:Cofactor_(biochemistry) dbr:Homology_(biology) dbr:Bond_cleavage dbc:Protein_targeting dbr:Phenylalanine dbr:HLA-E dbr:HM13 dbr:Methyl dbr:Natural_killer_cells dbr:Organism dbr:Sequence_motif dbr:Biogenesis dbr:Immunomodulator dbr:Immune_system dbr:Transmembrane_domain dbr:Secretion dbr:Five_prime_untranslated_region dbr:Protein_precursor dbr:Signal_peptidase dbr:Pilus dbr:Posttranslational_modification dbr:Epithelial_cell dbr:Aspartyl_protease dbr:Zinc_dependent_phospholipase_C |
| dbp:interpro |
IPR000045 (en) IPR007369 (en) |
| dbp:merops |
A22 (en) A24 (en) |
| dbp:name |
Peptidase_A24 (en) Peptidase_A22B (en) |
| dbp:opmFamily |
244 (xsd:integer) |
| dbp:opmProtein |
3 (xsd:integer) |
| dbp:pfam |
PF01478 (en) PF04258 (en) |
| dbp:pfamClan |
CL0130 (en) |
| dbp:symbol |
Peptidase_A24 (en) Peptidase_A22B (en) |
| dbp:wikiPageUsesTemplate |
dbt:Cite_journal dbt:Enzymes dbt:Infobox_protein_family dbt:MeshName dbt:Portal_bar dbt:Reflist dbt:UMichOPM dbt:Aspartic_acid_proteases |
| dcterms:subject |
dbc:Integral_membrane_proteins dbc:Hydrolases dbc:Proteases dbc:EC_3.4.23 dbc:Protein_targeting |
| gold:hypernym |
dbr:Protein |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment |
Signalpeptidasen, auch Signalasen, sind proteinspaltende Enzyme (Proteasen), die an der Membran des Endoplasmatischen Retikulums (ER) innerhalb der Zelle lokalisiert sind. Die Signalpeptidase erkennt spezielle Aminosäuresequenzen (Signalsequenzen) innerhalb eines Proteins. Sie spaltet im Lumen des ER das Signalpeptid von der restlichen Polypeptidkette ab. (de) In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins. It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). Its sequences is highly conserved in different vertebrate species. SPP cleaves remnant signal peptides left behind in membrane by the action of signal peptidase and also plays key roles in immune surveillance and the maturation of certain viral proteins. (en) |
| rdfs:label |
Signalpeptidase (de) Signal peptide peptidase (en) |
| owl:sameAs |
freebase:Signal peptide peptidase wikidata:Signal peptide peptidase dbpedia-de:Signal peptide peptidase https://global.dbpedia.org/id/27G6G |
| prov:wasDerivedFrom |
wikipedia-en:Signal_peptide_peptidase?oldid=1028761806&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:Signal_peptide_peptidase |
| is dbo:wikiPageRedirects of |
dbr:Signal_Peptide_Peptidase |
| is dbo:wikiPageWikiLink of |
dbr:Natural_killer_cell dbr:Index_of_biophysics_articles dbr:Intramembrane_protease dbr:Signal_Peptide_Peptidase dbr:Proinsulin dbr:SPPL2A dbr:SPPL2B dbr:HLA-E dbr:HM13 dbr:Signal_peptidase_I dbr:Rhomboid_protease |
| is rdfs:seeAlso of |
dbr:Signal_peptidase |
| is foaf:primaryTopic of |
wikipedia-en:Signal_peptide_peptidase |