| dbo:abstract |
Sofpironium bromide (trade name Ecclock; development code BBI-4000) is a drug used to treat hyperhidrosis (excessive sweating). It was approved in Japan in 2020 as a 5% gel for the treament of primary axillary hyperhidrosis (PAH). Sofpironium bromide is an anticholinergic agent that reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands. It is a retrometabolically-designed drug (or "soft drug") based on glycopyrronium bromide, meaning it has been designed to exert the desired effects at the site of administration, after which it is quickly converted into an inactive non-toxic metabolite upon entering systemic circulation avoiding the typical anticholinergic side-effects caused by off-site action. (en) ソフピロニウム臭化物（ソフピロニウムしゅうかぶつ、英: Sofpironium bromide、BBI-4000）は、初の原発性腋窩多汗症外用治療剤（止汗剤）。 (ja) |
| dbo:alternativeName |
Ecclock (en) |
| dbo:casNumber |
1628106-94-4 |
| dbo:chEMBL |
3707223 |
| dbo:fdaUniiCode |
7B2Y1932XU |
| dbo:kegg |
D10989 |
| dbo:pubchem |
86301316 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Sofpironium_bromide.svg?width=300 |
| dbo:wikiPageID |
68038337 (xsd:integer) |
| dbo:wikiPageLength |
5795 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1030794321 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Hyperhidrosis dbc:Carboxylate_esters dbc:Pyrrolidines dbc:Tertiary_alcohols dbr:Glycopyrronium_bromide dbr:Anticholinergic dbr:Systemic_circulation dbr:Muscarinic_acetylcholine_receptor_M3 dbr:Drug_metabolism dbc:Muscarinic_antagonists dbc:Quaternary_ammonium_compounds dbc:Bromides dbc:Dermatologic_drugs dbr:Retrometabolic_drug_design dbr:Eccrine_gland |
| dbp:br |
1 (xsd:integer) |
| dbp:c |
22 (xsd:integer) |
| dbp:casNumber |
1628106 (xsd:integer) |
| dbp:chembl |
3707223 (xsd:integer) |
| dbp:chemspiderid |
52085312 (xsd:integer) |
| dbp:h |
32 (xsd:integer) |
| dbp:iupacName |
[-1--1-methylpyrrolidin-1-ium-3-yl] -2-cyclopentyl-2-hydroxy-2-phenylacetate bromide (en) |
| dbp:kegg |
D10989 (en) |
| dbp:legalStatus |
Rx-only (en) |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
5 (xsd:integer) |
| dbp:pubchem |
86301316 (xsd:integer) |
| dbp:routesOfAdministration |
Topical gel (en) |
| dbp:smiles |
CCOCC[N+]1C.[Br-] (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
FIAFMTCUJCWADZ-JOFREBOKSA-M (en) |
| dbp:synonyms |
BBI 4000 (en) |
| dbp:tradename |
Ecclock (en) |
| dbp:unii |
7 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Infobox_drug dbt:Reflist dbt:Muscarinic_acetylcholine_receptor_modulators |
| dct:subject |
dbc:Carboxylate_esters dbc:Pyrrolidines dbc:Tertiary_alcohols dbc:Muscarinic_antagonists dbc:Quaternary_ammonium_compounds dbc:Bromides dbc:Dermatologic_drugs |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment |
ソフピロニウム臭化物（ソフピロニウムしゅうかぶつ、英: Sofpironium bromide、BBI-4000）は、初の原発性腋窩多汗症外用治療剤（止汗剤）。 (ja) Sofpironium bromide (trade name Ecclock; development code BBI-4000) is a drug used to treat hyperhidrosis (excessive sweating). It was approved in Japan in 2020 as a 5% gel for the treament of primary axillary hyperhidrosis (PAH). (en) |
| rdfs:label |
ソフピロニウム (ja) Sofpironium bromide (en) |
| owl:sameAs |
wikidata:Sofpironium bromide dbpedia-ja:Sofpironium bromide https://global.dbpedia.org/id/2YaWd |
| prov:wasDerivedFrom |
wikipedia-en:Sofpironium_bromide?oldid=1030794321&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Sofpironium_bromide.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Sofpironium_bromide |
| is dbo:wikiPageRedirects of |
dbr:Ecclock dbr:BBI-4000 dbr:Sofpironium |
| is dbo:wikiPageWikiLink of |
dbr:Ecclock dbr:BBI-4000 dbr:Sofpironium |
| is foaf:primaryTopic of |
wikipedia-en:Sofpironium_bromide |
