Sp7 transcription factor (original) (raw)
O fator de transcrição Sp7, também conhecido como osterix, é uma proteína que, em humanos, é codificada pelo gene SP7.
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| dbo:abstract | Transcription factor Sp7, also called osterix (Osx), is a protein that in humans is encoded by the SP7 gene. It is a member of the Sp family of zinc-finger transcription factors It is highly conserved among bone-forming vertebrate species It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into osteoblasts and eventually osteocytes. Sp7 also plays a regulatory role by inhibiting chondrocyte differentiation maintaining the balance between differentiation of mesenchymal precursor cells into ossified bone or cartilage. Mutations of this gene have been associated with multiple dysfunctional bone phenotypes in vertebrates. During development, a mouse embryo model with Sp7 expression knocked out had no formation of bone tissue. Through the use of GWAS studies, the Sp7 locus in humans has been strongly associated with bone mass density. In addition there is significant genetic evidence for its role in diseases such as Osteogenesis imperfecta (OI). (en) SP7 (англ. Sp7 transcription factor 7) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми. Довжина поліпептидного ланцюга білка становить 428 амінокислот, а молекулярна маса — 44 718. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до активаторів. Задіяний у таких біологічних процесах, як транскрипція, регуляція транскрипції. Білок має сайт для зв'язування з іонами металів, іоном цинку, ДНК. Локалізований у ядрі. (uk) O fator de transcrição Sp7, também conhecido como osterix, é uma proteína que, em humanos, é codificada pelo gene SP7. (pt) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Regulatory_pathway_for_Sp7-Osx.png?width=300 |
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| gold:hypernym | dbr:Protein |
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| rdfs:comment | O fator de transcrição Sp7, também conhecido como osterix, é uma proteína que, em humanos, é codificada pelo gene SP7. (pt) Transcription factor Sp7, also called osterix (Osx), is a protein that in humans is encoded by the SP7 gene. It is a member of the Sp family of zinc-finger transcription factors It is highly conserved among bone-forming vertebrate species It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into osteoblasts and eventually osteocytes. Sp7 also plays a regulatory role by inhibiting chondrocyte differentiation maintaining the balance between differentiation of mesenchymal precursor cells into ossified bone or cartilage. Mutations of this gene have been associated with multiple dysfunctional bone phenotypes in vertebrates. During development, a mouse embryo model with Sp7 expression knocked out had no formation of bone tissue. Through t (en) SP7 (англ. Sp7 transcription factor 7) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми. Довжина поліпептидного ланцюга білка становить 428 амінокислот, а молекулярна маса — 44 718. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | Fator de transcrição Sp7 (pt) Sp7 transcription factor (en) SP7 (uk) |
| owl:sameAs | freebase:Sp7 transcription factor yago-res:Sp7 transcription factor wikidata:Sp7 transcription factor dbpedia-pt:Sp7 transcription factor dbpedia-uk:Sp7 transcription factor https://global.dbpedia.org/id/zuCk |
| prov:wasDerivedFrom | wikipedia-en:Sp7_transcription_factor?oldid=1092976630&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Frontal_Parietal_Cranial_Bone_Sp7_mutant.png wiki-commons:Special:FilePath/Osteogenesis_Imperfecta_Type_V.jpg wiki-commons:Special:FilePath/Regulatory_pathway_for_Sp7-Osx.png wiki-commons:Special:FilePath/Sp7diagram2.png |
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| is foaf:primaryTopic of | wikipedia-en:Sp7_transcription_factor |
