StAR-related transfer domain (original) (raw)
START (StAR-related lipid-transfer) is a lipid-binding domain in StAR, HD-ZIP and signalling proteins. The archetypical domain is found in StAR (Steroidogenic acute regulatory protein), a mitochondrial protein that is synthesized in steroid-producing cells. StAR initiates steroid production by mediating the delivery of cholesterol to the first enzyme in steroidogenic pathway. The START domain is critical for this activity, perhaps through the binding of cholesterol. Following the discovery of StAR, 15 START-domain-containing proteins (termed STARD1 through STARD15) were subsequently identified in vertebrates as well as other that are related.
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| dbo:abstract | START (StAR-related lipid-transfer) is a lipid-binding domain in StAR, HD-ZIP and signalling proteins. The archetypical domain is found in StAR (Steroidogenic acute regulatory protein), a mitochondrial protein that is synthesized in steroid-producing cells. StAR initiates steroid production by mediating the delivery of cholesterol to the first enzyme in steroidogenic pathway. The START domain is critical for this activity, perhaps through the binding of cholesterol. Following the discovery of StAR, 15 START-domain-containing proteins (termed STARD1 through STARD15) were subsequently identified in vertebrates as well as other that are related. Thousands of proteins containing at least one START domain have been determined in invertebrates, bacteria and plants to form a larger superfamily, variously known as START, Bet v1-like or SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) domain proteins, all of which bind hydrophobic ligands. In the case of plants, many of the START proteins fall into the category of putative lipid/sterol-binding homeodomain (HD) transcription factors or HD-START proteins. Representatives of the START domain family bind different substances or ligands such as sterols (e.g., StAR or STARD1) and lipids like phosphatidylcholine (phosphatidylcholine transfer protein, also called PCTP or STARD2) and have enzymatic activities. Ligand binding by the START domain in multidomain proteins can also regulate the activities of the other domains, such as the RhoGAP domain, the homeodomain and the thioesterase domain. (en) |
| dbo:symbol | START |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1em2_EBI.jpg?width=300 |
| dbo:wikiPageID | 29159323 (xsd:integer) |
| dbo:wikiPageLength | 6793 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1119836250 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Bet_v_I_allergen dbr:RhoGAP_domain dbr:Cyclase dbr:Steroidogenic_acute_regulatory_protein dbr:STARD8 dbr:Ligands dbr:Steroid dbr:Sterols dbr:Phosphatidylcholine dbr:Bacteria dbr:DLC1 dbr:STARD7 dbr:Polyketide dbr:STARD4 dbc:Peripheral_membrane_proteins dbr:Kinesin dbc:Protein_domains dbr:Invertebrates dbr:Thioesterase dbr:ACOT11 dbr:ACOT12 dbc:Water-soluble_transporters dbr:Plants dbr:COL4A3BP dbr:Sterol_carrier_protein dbr:STARD3 dbr:Phosphatidylcholine_transfer_protein dbr:Phosphatidylinositol_transfer_protein dbr:STARD13 dbr:STARD5 dbr:STARD10 dbr:Vertebrates dbr:Homeodomain dbr:MLN64 dbr:KIF16A |
| dbp:caption | star-related lipid transport domain of mln64 (en) |
| dbp:cdd | cd00177 (en) |
| dbp:interpro | IPR002913 (en) |
| dbp:membranomeSuperfamily | 564 (xsd:integer) |
| dbp:name | START (en) START domain (en) |
| dbp:opmFamily | 138 (xsd:integer) |
| dbp:opmProtein | 1 (xsd:integer) |
| dbp:pfam | PF01852 (en) |
| dbp:pfamClan | CL0209 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:smart | START (en) |
| dbp:symbol | START (en) |
| dbp:tcdb | 9 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist dbt:Short_description dbt:Pfam_box |
| dct:subject | dbc:Peripheral_membrane_proteins dbc:Protein_domains dbc:Water-soluble_transporters |
| gold:hypernym | dbr:Domain |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment | START (StAR-related lipid-transfer) is a lipid-binding domain in StAR, HD-ZIP and signalling proteins. The archetypical domain is found in StAR (Steroidogenic acute regulatory protein), a mitochondrial protein that is synthesized in steroid-producing cells. StAR initiates steroid production by mediating the delivery of cholesterol to the first enzyme in steroidogenic pathway. The START domain is critical for this activity, perhaps through the binding of cholesterol. Following the discovery of StAR, 15 START-domain-containing proteins (termed STARD1 through STARD15) were subsequently identified in vertebrates as well as other that are related. (en) |
| rdfs:label | StAR-related transfer domain (en) |
| owl:sameAs | freebase:StAR-related transfer domain wikidata:StAR-related transfer domain https://global.dbpedia.org/id/4vPu5 |
| prov:wasDerivedFrom | wikipedia-en:StAR-related_transfer_domain?oldid=1119836250&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1em2_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:StAR-related_transfer_domain |
| is dbo:wikiPageRedirects of | dbr:START_domain |
| is dbo:wikiPageWikiLink of | dbr:START_domain dbr:Steroidogenic_acute_regulatory_protein dbr:STARD7 dbr:STARD4 dbr:ACOT1 dbr:Star_related_lipid_transfer_domain_containing_3 dbr:ACOT11 dbr:ACOT12 dbr:COL4A3BP dbr:STARD3NL dbr:Phosphatidylcholine_transfer_protein dbr:Phosphatidylinositol_transfer_protein dbr:STARD5 |
| is foaf:primaryTopic of | wikipedia-en:StAR-related_transfer_domain |
