| dbo:abstract |
Sunflower trypsin inhibitor (SFTI) is a small, circular peptide produced in sunflower seeds, and is a potent inhibitor of trypsin. It is the smallest known member of the Bowman-Birk family of serine protease inhibitors. One example of Sunflower trypsin inhibitor is Sunflower trypsin inhibitor-1 (SFTI-1). Sunflower trypsin inhibitor-1 is a potent Bowman-Birk inhibitor. Sunflower trypsin inhibitor-1 is the simplest cysteine-rich peptide scaffold because it is a bicyclic 14 amino acid peptide and only has one disulfide bond. The disulfide bond divides the peptide into two loops. One loop is a functional trypsin inhibitory and the second loop is a nonfunctional loop. The nonfunctional loop can be replaced by a bioactive loop. It is extracted from a seed of a sunflower called Helianthus annuus. The synthesis of SFTI is not known however, it can evolutionarily linked to a gene-coded product from classic Bowman-Birk inhibitors. STFI is used in radiopharmaceutical, antimicrobial, and pro-angiogenic peptides. (en) |
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dbr:Proline dbr:Bowman-Birk_protease_inhibitor dbr:Peptide dbr:University_College_London dbr:KLK14 dbr:Glycine dbr:Lysine dbr:Sunflower_seed dbr:Tryptophan dbr:KLK7 dbr:Histidine dbr:Isoleucine dbr:Arginine dbr:Aspartic_acid dbc:Peptides dbr:KLK5 dbr:C-terminus dbr:Phenylalanine dbr:Trypsin |
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dbt:Biochemistry-stub dbt:Reflist |
| dct:subject |
dbc:Peptides |
| gold:hypernym |
dbr:Peptide |
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yago:Abstraction100002137 yago:Amide114724264 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Peptide114743046 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound yago:Substance100019613 yago:WikicatPeptides |
| rdfs:comment |
Sunflower trypsin inhibitor (SFTI) is a small, circular peptide produced in sunflower seeds, and is a potent inhibitor of trypsin. It is the smallest known member of the Bowman-Birk family of serine protease inhibitors. (en) |
| rdfs:label |
Sunflower trypsin inhibitor (en) |
| owl:sameAs |
freebase:Sunflower trypsin inhibitor wikidata:Sunflower trypsin inhibitor https://global.dbpedia.org/id/4vdCr yago-res:Sunflower trypsin inhibitor |
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wikipedia-en:Sunflower_trypsin_inhibitor?oldid=1087294459&ns=0 |
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wikipedia-en:Sunflower_trypsin_inhibitor |
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wikipedia-en:Sunflower_trypsin_inhibitor |