| dbo:abstract |
Sunifiram (DM-235) es un fármaco ampakina que actúa como un modulador alostérico positivo del receptor AMPA, que ha demostrado tener efectos nootrópicos en animales con una potencia significativamente mayor al que presenta el piracetam. Una serie de compuestos relacionados son conocidos, siendo uno de ellos el unifiram (DM-232). (es) Sunifiram, noms chimiques 1-(4-benzoyl-1-pipérazinyl)-1-propanone et 1-benzoyl-4-propanoylpiperazine, formule chimique C14H20N2O2, nom de code de développement DM-235 est un médicament expérimental qui a des effets antiamnésiques dans les études animales et avec une puissance significativement plus élevée que le piracétam. Le sunifiram est une simplification moléculaire de l' (DM-232). Un autre analogue est le (MN-19). En 2016, le sunifiram n'avait été soumis à aucun test toxicologique, ni à aucun essai clinique sur l'homme, et son utilisation médicinale n'est approuvée nulle part dans le monde. (fr) Sunifiram (developmental code name DM-235) is an experimental drug which has antiamnesic effects in animal studies and with significantly higher potency than piracetam. Sunifiram is a molecular simplification of unifiram (DM-232). Another analogue is (MN-19). As of 2016, sunifiram had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world. (en) |
| dbo:casNumber |
314728-85-3 |
| dbo:chEMBL |
309176 |
| dbo:fdaUniiCode |
66924E735K |
| dbo:pubchem |
4223812 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Sunifiram.svg?width=300 |
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dbr:Potency_(pharmacology) dbr:Scopolamine dbr:Membrane_transport_protein dbr:Animal_studies dbr:Pentobarbital dbr:Unifiram dbr:Dopamine_receptor dbr:In_vitro dbc:Designer_drugs dbc:Piperazines dbr:Opioid_receptor dbr:Glucose dbr:NBQX dbr:NSI-189 dbr:Aniracetam dbr:Levetiracetam dbr:Clinical_trial dbr:Receptor_antagonist dbr:Barbiturate dbr:Bucinnazine dbr:Toxicology dbr:GABA_receptor dbr:Ion_channel dbr:PKC_alpha dbr:Adrenergic_receptor dbr:Amnesia dbc:Benzamides dbc:Nootropics dbr:Glutamate_receptor dbr:Histamine_receptor dbr:Upstream_and_downstream_(transduction) dbr:Receptor_(biochemistry) dbr:AMPA_receptor dbr:AMPA_receptor_positive_allosteric_modulator dbr:Acetylcholine_receptor dbc:Drugs_with_unknown_mechanisms_of_action dbr:Affinity_(pharmacology) dbr:Diazepam dbr:Ca2+/calmodulin-dependent_protein_kinase_II dbr:Piracetam dbr:Mechanism_of_action dbr:Experimental_drug dbr:NMDA_receptor dbr:Serotonin_receptor dbr:Erythrocyte dbr:Antiamnesic dbr:Sapunifiram |
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| dbp:h |
18 (xsd:integer) |
| dbp:iupacName |
1 (xsd:integer) |
| dbp:legalUs |
Not FDA approved; unscheduled (en) |
| dbp:n |
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| dbp:o |
2 (xsd:integer) |
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| dbp:smiles |
CCCN1CCNCc2ccccc2 (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
DGOWDUFJCINDGI-UHFFFAOYSA-N (en) |
| dbp:synonyms |
DM-235 (en) |
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changed (en) |
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changed (en) |
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| dcterms:subject |
dbc:Designer_drugs dbc:Piperazines dbc:Benzamides dbc:Nootropics dbc:Drugs_with_unknown_mechanisms_of_action |
| gold:hypernym |
dbr:Piperazine |
| rdf:type |
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| rdfs:comment |
Sunifiram (DM-235) es un fármaco ampakina que actúa como un modulador alostérico positivo del receptor AMPA, que ha demostrado tener efectos nootrópicos en animales con una potencia significativamente mayor al que presenta el piracetam. Una serie de compuestos relacionados son conocidos, siendo uno de ellos el unifiram (DM-232). (es) Sunifiram (developmental code name DM-235) is an experimental drug which has antiamnesic effects in animal studies and with significantly higher potency than piracetam. Sunifiram is a molecular simplification of unifiram (DM-232). Another analogue is (MN-19). As of 2016, sunifiram had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world. (en) Sunifiram, noms chimiques 1-(4-benzoyl-1-pipérazinyl)-1-propanone et 1-benzoyl-4-propanoylpiperazine, formule chimique C14H20N2O2, nom de code de développement DM-235 est un médicament expérimental qui a des effets antiamnésiques dans les études animales et avec une puissance significativement plus élevée que le piracétam. Le sunifiram est une simplification moléculaire de l' (DM-232). Un autre analogue est le (MN-19). (fr) |
| rdfs:label |
Sunifiram (es) Sunifiram (fr) Sunifiram (en) |
| owl:sameAs |
freebase:Sunifiram yago-res:Sunifiram wikidata:Sunifiram dbpedia-es:Sunifiram dbpedia-fr:Sunifiram dbpedia-hu:Sunifiram dbpedia-sh:Sunifiram dbpedia-sr:Sunifiram https://global.dbpedia.org/id/4qc89 |
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wikipedia-en:Sunifiram?oldid=1079722948&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Sunifiram.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Sunifiram |
| is dbo:wikiPageWikiLink of |
dbr:Methoxypiperamide dbr:Benzamide dbr:Unifiram dbr:Bucinnazine dbr:C14H18N2O2 dbr:Piperazine dbr:FK962 dbr:Substituted_piperazine |
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wikipedia-en:Sunifiram |
