Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It dephosphorylates the D-5 position phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and Phosphatidylinositol (4,5)-bisphosphate(PIP2). It belongs to family of 5-phosphatases, which are structurally unrelated to D-3 inositol phosphatases like PTEN. Other members of the family of 5'phosphoinositide phosphatases include OCRL, SHIP1, SHIP2, INPP5J, INPP5E, INPP5B, INPP5A and SKIP.
| Property |
Value |
| dbo:abstract |
Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It dephosphorylates the D-5 position phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and Phosphatidylinositol (4,5)-bisphosphate(PIP2). It belongs to family of 5-phosphatases, which are structurally unrelated to D-3 inositol phosphatases like PTEN. Other members of the family of 5'phosphoinositide phosphatases include OCRL, SHIP1, SHIP2, INPP5J, INPP5E, INPP5B, INPP5A and SKIP. (en) |
| dbo:arm |
q |
| dbo:band |
22.2 25.3 |
| dbo:chromosome |
21 6 |
| dbo:entrezgene |
8867 8871 |
| dbo:hgncid |
11503 11504 |
| dbo:omim |
604297 (xsd:integer) 609410 (xsd:integer) |
| dbo:refseq |
NM_003895 NM_003898 |
| dbo:symbol |
SYNJ1 SYNJ2 |
| dbo:uniprot |
O15056 O43426 |
| dbo:wikiPageID |
9859540 (xsd:integer) |
| dbo:wikiPageLength |
14782 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1075845044 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Mutant dbr:Dephosphorylation dbr:Indirect_calorimetry dbr:International_Knockout_Mouse_Consortium dbc:EC_3.1.3 dbr:Neuron dbr:Homozygote dbr:Phosphatidylinositol_(4,5)-bisphosphate dbr:Clinical_chemistry dbr:Hot_plate_test dbr:PTEN_(gene) dbr:Parkinsonism dbr:Peripheral_blood_lymphocyte dbr:Synapse dbr:Micronucleus_test dbr:Lipid dbc:Genes_mutated_in_mice dbc:Peripheral_membrane_proteins dbr:Dual-energy_X-ray_absorptiometry dbr:Glucose_tolerance_test dbr:Knockout_mouse dbr:Protein dbr:Haematology dbr:Model_organism dbr:Salmonella dbr:Auditory_brainstem_response dbr:Phosphate dbr:Phosphatidylinositol_(3,4,5)-trisphosphate dbr:Citrobacter dbr:Growth_cone dbr:Inositol dbr:Neurotransmitters dbr:Radiography dbr:Wellcome_Trust_Sanger_Institute dbr:Phosphatase dbr:Open_Field_(animal_test) dbr:Dysmorphology dbr:Phenotypic_screen |
| dbp:arm |
q (en) |
| dbp:band |
22.200000 (xsd:double) 25.300000 (xsd:double) |
| dbp:chromosome |
6 (xsd:integer) 21 (xsd:integer) |
| dbp:entrezgene |
8867 (xsd:integer) 8871 (xsd:integer) |
| dbp:hgncid |
11503 (xsd:integer) 11504 (xsd:integer) |
| dbp:name |
synaptojanin 1 (en) synaptojanin 2 (en) |
| dbp:omim |
604297 (xsd:integer) 609410 (xsd:integer) |
| dbp:refseq |
NM_003895 (en) NM_003898 (en) |
| dbp:symbol |
SYNJ1 (en) SYNJ2 (en) |
| dbp:uniprot |
O15056 (en) O43426 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Enzymes dbt:Esterases dbt:MeshName dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Infobox_protein |
| dcterms:subject |
dbc:EC_3.1.3 dbc:Genes_mutated_in_mice dbc:Peripheral_membrane_proteins |
| gold:hypernym |
dbr:Protein |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Arrangement107938773 yago:Chemical114806838 yago:Compound114818238 yago:Gene105436752 yago:Group100031264 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:Ordering108456993 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:WikicatGenesMutatedInMice dbo:Protein yago:Sequence108459252 yago:Series108457976 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatPeripheralMembraneProteins |
| rdfs:comment |
Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It dephosphorylates the D-5 position phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and Phosphatidylinositol (4,5)-bisphosphate(PIP2). It belongs to family of 5-phosphatases, which are structurally unrelated to D-3 inositol phosphatases like PTEN. Other members of the family of 5'phosphoinositide phosphatases include OCRL, SHIP1, SHIP2, INPP5J, INPP5E, INPP5B, INPP5A and SKIP. (en) |
| rdfs:label |
Synaptojanin (en) |
| owl:sameAs |
freebase:Synaptojanin yago-res:Synaptojanin wikidata:Synaptojanin https://global.dbpedia.org/id/2mrRy |
| prov:wasDerivedFrom |
wikipedia-en:Synaptojanin?oldid=1075845044&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:Synaptojanin |
| foaf:name |
synaptojanin 1 (en) synaptojanin 2 (en) |
| is dbo:wikiPageRedirects of |
dbr:Synj2 |
| is dbo:wikiPageWikiLink of |
dbr:Endonuclease/Exonuclease/phosphatase_family dbr:Hugo_J._Bellen dbr:HSPA8 dbr:Fig4 dbr:CFAP298 dbr:SacI_homology_domain dbr:Synj2 |
| is foaf:primaryTopic of |
wikipedia-en:Synaptojanin |