| dbo:abstract |
T98G is a glioblastoma cell line used in brain cancer research and drug development. The T98G cell line was derived from a 61-year-old human male and has a hyperpentaploid chromosome count with a modal number ranging from 128 to 132. The cells are not tumorigenic in mice, but do proliferate with proper anchorage in cell culture. T98G cells are known for having high expression of the ACTA2 gene, which is involved in cell motility and structure. T98G cells are polyploidy variants of the parent T98 cell line, and can stay in the G1 phase of the cell cycle under stationary conditions. T98G cells have been investigated along with A172 cells for drug cytotoxicity, and were found to be resistant to cisplatin, with larger cytotoxic effects induced by viral-mediated production of the p53 protein. (en) T98G是應用於腦癌研究和藥物開發的人類膠質母細胞瘤細胞系，最初分離自61歲的男性膠質母細胞瘤患者。T98G細胞具有超五倍體的染色體數，模態數範圍為128至132。這些細胞在小鼠中沒有致瘤性，但在細胞培養中具有適當的錨定性時可以進行增殖。T98G細胞的其中一個特點是高度表達着，而該基因參與着肌肉收縮活動。T98G細胞是T98親本細胞系的多倍體變體，在穩態條件下可以停留在細胞週期中的G1期。目前已經研究了T98G細胞和A172細胞的藥物細胞毒性，發現它們都對順鉑（一種非特異性藥物）具有抗性，並且通過病毒介導的p53蛋白產生，具有更高的細胞毒性作用。 (zh) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Protein_ACTA2_PDB_1atn.png?width=300 |
| dbo:wikiPageExternalLink |
https://www.cellosaurus.org/CVCL_0556 |
| dbo:wikiPageID |
57318258 (xsd:integer) |
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2290 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1108080213 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Cytotoxicity dbr:P53 dbr:Cisplatin dbr:Glioblastoma dbc:Human_cell_lines dbr:G1_phase dbr:Carcinogenesis dbr:Cell_culture dbr:ACTA2 dbr:Polyploidy dbr:Brain_cancer dbr:Cell_line dbr:Cell_motility dbr:File:Protein_ACTA2_PDB_1atn.png |
| dbp:wikiPageUsesTemplate |
dbt:Reflist |
| dct:subject |
dbc:Human_cell_lines |
| rdfs:comment |
T98G是應用於腦癌研究和藥物開發的人類膠質母細胞瘤細胞系，最初分離自61歲的男性膠質母細胞瘤患者。T98G細胞具有超五倍體的染色體數，模態數範圍為128至132。這些細胞在小鼠中沒有致瘤性，但在細胞培養中具有適當的錨定性時可以進行增殖。T98G細胞的其中一個特點是高度表達着，而該基因參與着肌肉收縮活動。T98G細胞是T98親本細胞系的多倍體變體，在穩態條件下可以停留在細胞週期中的G1期。目前已經研究了T98G細胞和A172細胞的藥物細胞毒性，發現它們都對順鉑（一種非特異性藥物）具有抗性，並且通過病毒介導的p53蛋白產生，具有更高的細胞毒性作用。 (zh) T98G is a glioblastoma cell line used in brain cancer research and drug development. The T98G cell line was derived from a 61-year-old human male and has a hyperpentaploid chromosome count with a modal number ranging from 128 to 132. The cells are not tumorigenic in mice, but do proliferate with proper anchorage in cell culture. T98G cells are known for having high expression of the ACTA2 gene, which is involved in cell motility and structure. T98G cells are polyploidy variants of the parent T98 cell line, and can stay in the G1 phase of the cell cycle under stationary conditions. (en) |
| rdfs:label |
T98G (en) T98G (zh) |
| owl:sameAs |
wikidata:T98G dbpedia-zh:T98G https://global.dbpedia.org/id/5gPSk |
| prov:wasDerivedFrom |
wikipedia-en:T98G?oldid=1108080213&ns=0 |
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wiki-commons:Special:FilePath/Protein_ACTA2_PDB_1atn.png |
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wikipedia-en:T98G |
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dbr:Cell_culture |
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wikipedia-en:T98G |
