TAP Pharmaceuticals (original) (raw)
TAP Pharmaceuticals was formed in 1977 as a joint venture between the two global pharmaceutical companies, Abbott Laboratories and Takeda Pharmaceutical Co. and was dissolved in 2008; its two most lucrative products were proton-pump inhibitor lansoprazole (Prevacid) and the prostate cancer drug, leuprorelin (Lupron). The intention of the joint venture was to get products that Takeda had discovered developed, approved, and marketed in the US and Canada. In 1998 Takeda established its own US R&D and sales force, for the diabetes drug pioglitazone (Actos).
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| dbo:abstract | TAP Pharmaceuticals was formed in 1977 as a joint venture between the two global pharmaceutical companies, Abbott Laboratories and Takeda Pharmaceutical Co. and was dissolved in 2008; its two most lucrative products were proton-pump inhibitor lansoprazole (Prevacid) and the prostate cancer drug, leuprorelin (Lupron). The intention of the joint venture was to get products that Takeda had discovered developed, approved, and marketed in the US and Canada. The company was established at a time when Japanese pharmaceutical companies were seeking partnerships to access the US market. These efforts were supported by the Japanese government at the time to help the national economy compete in higher technology, as countries like South Korea, Taiwan were beginning to catch up with Japan in commodity production. Japanese pharmaceutical companies were especially strong in the fields of generating analogs of known cephalosporin antibiotics, cancer drugs, and cardiovascular drugs. The first products TAP file new drug applications for, were two cephalosporins, cefmenoxime (Cefmax) and cefsulodin (Cefonomil), estazolam for sleep disorders, and leuprorelin; leuprorelin was the first one approved, in 1985. In 1998 Takeda established its own US R&D and sales force, for the diabetes drug pioglitazone (Actos). In 2000, TAP's withdrew its new drug application for apomorphine (branded as "Uprima") as a treatment for erectile dysfunction after an FDA review panel raised questions about the drug's safety, due to many clinical trial subjects fainting after taking the drug. In 2001, the US Department of Justice, states attorneys general, and TAP Pharmaceutical Products settled criminal and civil charges against TAP related to federal and state medicare fraud and illegal marketing of the drug leuprorelin. TAP paid a total of 875million,whichwasarecordhighatthetime.The875 million, which was a record high at the time. The 875million,whichwasarecordhighatthetime.The875 million settlement broke down to 290millionforviolatingthePrescriptionDrugMarketingAct,290 million for violating the Prescription Drug Marketing Act, 290millionforviolatingthePrescriptionDrugMarketingAct,559.5 million to settle federal fraud charges for overcharging Medicare, and 25.5millionreimbursementto50statesandWashington,D.C.,forfilingfalseclaimswiththestates′Medicaidprograms.ThecasearoseundertheFalseClaimsActwithclaimsfiledbyDouglasDurand,aformerTAPvicepresidentofsales,andJosephGerstein,adoctoratTuftsUniversity′sHMOpractice.Durand,Gerstein,andTuftsshared25.5 million reimbursement to 50 states and Washington, D.C., for filing false claims with the states' Medicaid programs. The case arose under the False Claims Act with claims filed by Douglas Durand, a former TAP vice president of sales, and Joseph Gerstein, a doctor at Tufts University's HMO practice. Durand, Gerstein, and Tufts shared 25.5millionreimbursementto50statesandWashington,D.C.,forfilingfalseclaimswiththestates′Medicaidprograms.ThecasearoseundertheFalseClaimsActwithclaimsfiledbyDouglasDurand,aformerTAPvicepresidentofsales,andJosephGerstein,adoctoratTuftsUniversity′sHMOpractice.Durand,Gerstein,andTuftsshared95 million of the settlement. When the settlement was announced, the Department of Justice also announced that seven people were indicted on criminal charges by a grand jury; the DoJ also said that four doctors had already pled guilty for receiving kickbacks. As of 2003 around 12 TAP employees had been indicted and were contested the charges, and one had pled guilty. However, in July 2004 a federal jury in Boston declared all the defendants not guilty. Abbott and Takeda agreed to end the partnership in 2008, with Abbott keeping the rights to leuprorelin, which had sales in 2007 of 600millionandapatentexpiringin2015andtheapproximately300employeeswhoworkedontheproduct,andTakedakeepingtherightstolansoprazole,whichhadsalesof600 million and a patent expiring in 2015 and the approximately 300 employees who worked on the product, and Takeda keeping the rights to lansoprazole, which had sales of 600millionandapatentexpiringin2015andtheapproximately300employeeswhoworkedontheproduct,andTakedakeepingtherightstolansoprazole,whichhadsalesof2.3 billion in 2007 but was facing imminent generic competition, along with 800 employees in the U.S. and all the drugs in the TAP pipeline. Takeda was also obligated to pay Abbott about 1.5billionoverseveralyears.By2008,Takeda′sownsalesintheUSoutsideofTAPhadgrownto1.5 billion over several years. By 2008, Takeda's own sales in the US outside of TAP had grown to 1.5billionoverseveralyears.By2008,Takeda′sownsalesintheUSoutsideofTAPhadgrownto3 billion, mostly from sales of pioglitazone which by then was the best-selling diabetes drug in the world. (en) |
| dbo:fate | Dissolved (en) |
| dbo:foundingYear | 1977-01-01 (xsd:gYear) |
| dbo:industry | dbr:Pharmaceutical_company |
| dbo:parentCompany | dbr:Abbott_Laboratories dbr:Takeda_Pharmaceutical_Company |
| dbo:type | dbr:Joint_venture |
| dbo:wikiPageID | 7625133 (xsd:integer) |
| dbo:wikiPageLength | 7844 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1025305696 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Deerfield,_Illinois dbr:Joint_venture dbr:Pharmaceutical dbr:Pharmaceutical_company dbr:United_States dbr:Erectile_dysfunction dbr:Apomorphine dbr:Leuprorelin dbr:Medicare_fraud dbc:Pharmaceutical_companies_disestablished_in_2008 dbr:Cefmenoxime dbr:Cefsulodin dbr:Cephalosporin dbr:Tufts_University dbr:Abbott_Laboratories dbr:Drug_development dbr:Estazolam dbr:False_Claims_Act dbr:Japan dbc:Life_sciences_industry dbc:Pharmaceutical_companies_of_the_United_States dbr:Lansoprazole dbr:Takeda_Pharmaceutical_Company dbr:Pioglitazone dbr:Illinois dbr:Chuo,_Tokyo dbr:Nihonbashi dbr:New_drug_application dbr:List_of_Largest_Pharmaceutical_Settlements dbr:Takeda_Pharmaceutical_Co. |
| dbp:defunct | 2008 (xsd:integer) |
| dbp:fate | Dissolved (en) |
| dbp:foundation | 1977 (xsd:integer) |
| dbp:imageCaption | Global headquarters in Nihonbashi (en) |
| dbp:industry | dbr:Pharmaceutical_company |
| dbp:locationCity | dbr:Deerfield,_Illinois dbr:United_States dbr:Illinois dbr:Chuo,_Tokyo dbr:Nihonbashi |
| dbp:locationCountry | dbr:Japan |
| dbp:name | TAP Pharmaceuticals Inc. (en) |
| dbp:parent | dbr:Abbott_Laboratories dbr:Takeda_Pharmaceutical_Company |
| dbp:type | dbr:Joint_venture |
| dbp:wikiPageUsesTemplate | dbt:Infobox_company dbt:Reflist dbt:Pharmaceutical_companies_of_the_United_States |
| dcterms:subject | dbc:Pharmaceutical_companies_disestablished_in_2008 dbc:Life_sciences_industry dbc:Pharmaceutical_companies_of_the_United_States |
| gold:hypernym | dbr:Company |
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| rdfs:comment | TAP Pharmaceuticals was formed in 1977 as a joint venture between the two global pharmaceutical companies, Abbott Laboratories and Takeda Pharmaceutical Co. and was dissolved in 2008; its two most lucrative products were proton-pump inhibitor lansoprazole (Prevacid) and the prostate cancer drug, leuprorelin (Lupron). The intention of the joint venture was to get products that Takeda had discovered developed, approved, and marketed in the US and Canada. In 1998 Takeda established its own US R&D and sales force, for the diabetes drug pioglitazone (Actos). (en) |
| rdfs:label | TAP Pharmaceuticals (en) |
| owl:sameAs | freebase:TAP Pharmaceuticals yago-res:TAP Pharmaceuticals wikidata:TAP Pharmaceuticals https://global.dbpedia.org/id/4vWVU |
| prov:wasDerivedFrom | wikipedia-en:TAP_Pharmaceuticals?oldid=1025305696&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:TAP_Pharmaceuticals |
| foaf:name | TAP Pharmaceuticals Inc. (en) |
| is dbo:wikiPageDisambiguates of | dbr:Tap |
| is dbo:wikiPageRedirects of | dbr:TAP_Pharmaceutical_Products dbr:TAP_Pharmaceutical_Products,_Inc |
| is dbo:wikiPageWikiLink of | dbr:Apomorphine dbr:Leuprorelin dbr:Tap dbr:Cefsulodin dbr:Febuxostat dbr:Jeffrey_Leiden dbr:Takeda_Pharmaceutical_Company dbr:Michael_Sullivan_(U.S._Attorney) dbr:TAP_Pharmaceutical_Products dbr:TAP_Pharmaceutical_Products,_Inc |
| is foaf:primaryTopic of | wikipedia-en:TAP_Pharmaceuticals |