TENM3 (original) (raw)
Teneurin-3, also known as Ten-m3, Odz3, Ten-m/Odz3, Tenascin-like molecule major 3 or Teneurin transmembrane protein 3, is a protein that, in humans, is encoded by the TENM3, or ODZ3, gene. Ten-m3 is a ~300 kDa type II transmembrane glycoprotein that is a member of the teneurin/Ten-m/Odz family. The teneurin family currently consists of four members: Ten-m1-Ten-m4. Ten-ms are conserved across both vertebrate and invertebrate species. They are expressed in distinct, but often interconnected, areas of the developing nervous system and in some non-neural tissues. Like the Ten-m family, Ten-m3 plays a critical role in regulating connectivity of the nervous system, particularly in axon pathfinding and synaptic organisation in the motor and visual system. Mutation in the TENM3/ODZ3 gene in human
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| dbo:abstract | Teneurin-3, also known as Ten-m3, Odz3, Ten-m/Odz3, Tenascin-like molecule major 3 or Teneurin transmembrane protein 3, is a protein that, in humans, is encoded by the TENM3, or ODZ3, gene. Ten-m3 is a ~300 kDa type II transmembrane glycoprotein that is a member of the teneurin/Ten-m/Odz family. The teneurin family currently consists of four members: Ten-m1-Ten-m4. Ten-ms are conserved across both vertebrate and invertebrate species. They are expressed in distinct, but often interconnected, areas of the developing nervous system and in some non-neural tissues. Like the Ten-m family, Ten-m3 plays a critical role in regulating connectivity of the nervous system, particularly in axon pathfinding and synaptic organisation in the motor and visual system. Mutation in the TENM3/ODZ3 gene in humans has been associated with the eye condition, microphthalmia. (en) TENM3 (англ. Teneurin transmembrane protein 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 4-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 699 амінокислот, а молекулярна маса — 300 950. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у таких біологічних процесах як клітинна адгезія, диференціація, поліморфізм. Локалізований у мембрані, клітинних відростках. (uk) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Ten-m3_Structure.png?width=300 |
| dbo:wikiPageExternalLink | https://semanticscholar.org/paper/2eb213b62c724a3a979ded7e8c53157335e1d094 |
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| dbo:wikiPageWikiLink | dbr:Caenorhabditis_elegans dbr:Proline dbr:Mouse dbr:Mutation dbr:Nervous_system dbr:Mesenchyme dbr:Human dbr:Retina dbr:Vertebrate dbr:Visual_system dbr:EGF-like_domain dbr:Polymerase_chain_reaction dbr:Chicken dbr:Neocortex dbr:Otic_vesicle dbr:Teneurin dbr:Embryonic_development dbr:Embryos dbr:Monoclonal_antibodies dbr:NHL_repeat dbr:Corticotropin-releasing_hormone dbr:Transmembrane_proteins dbr:Basolateral_amygdala dbr:Coloboma dbr:Dentate_gyrus dbr:Zebrafish dbr:Furin dbr:Startle_response dbr:Autosomal_recessive dbr:Cerebellum dbr:Cerebrum dbr:Tyrosine dbr:Lateral_geniculate_nucleus dbr:Lateral_ventricles dbr:Latrophilin dbr:Cyclic_adenosine_monophosphate dbr:Cysteine dbr:Drosophila dbr:Diencephalon dbr:Dimer_(chemistry) dbr:Forebrain dbr:Globular_protein dbr:Glycoprotein dbr:Glycosylation dbr:Hindbrain dbr:Hippocampus dbr:Superior_colliculus dbr:Visual_cortex dbr:G-protein_coupled_receptor dbr:Protein_folding dbr:Visual_field dbr:Invertebrate dbr:Telencephalon dbr:EF-hand dbr:Transmembrane_protein dbr:CDNA dbc:Genes_on_human_chromosome_4 dbr:Binocular_vision dbr:Tenascin_C dbr:Disulfide_bonds dbr:C-terminus dbr:Hydrophobic dbr:Microphthalmia dbr:Midbrain dbr:Rat dbr:Sensitisation dbr:White_matter dbr:Wild_type dbr:Neural_plate dbr:N-terminus dbr:Spinal_cord dbr:Motor_system dbr:Tyrosine_phosphorylation dbr:Thalamus dbr:Striatum dbr:SH3_domain dbr:Visual_pathway dbr:Neural_folds dbr:Retinal_ganglion_cells dbr:Retinotopic dbr:Axon_pathfinding dbr:Limb_buds dbr:Proteolytic_cleavage dbr:Somites dbr:Orthologs dbr:Parafascicular_nucleus dbr:Paralogs dbr:Pharyngeal_arches dbr:In_situ_hybridisation dbr:Nuclear_localisation_signal dbr:File:Ten-m3_Structure.png |
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| dcterms:subject | dbc:Genes_on_human_chromosome_4 |
| gold:hypernym | dbr:Protein |
| rdf:type | yago:Abstraction100002137 yago:Arrangement107938773 yago:Gene105436752 yago:Group100031264 yago:Ordering108456993 yago:WikicatGenesOnChromosome4 dbo:Protein yago:Sequence108459252 yago:Series108457976 |
| rdfs:comment | Teneurin-3, also known as Ten-m3, Odz3, Ten-m/Odz3, Tenascin-like molecule major 3 or Teneurin transmembrane protein 3, is a protein that, in humans, is encoded by the TENM3, or ODZ3, gene. Ten-m3 is a ~300 kDa type II transmembrane glycoprotein that is a member of the teneurin/Ten-m/Odz family. The teneurin family currently consists of four members: Ten-m1-Ten-m4. Ten-ms are conserved across both vertebrate and invertebrate species. They are expressed in distinct, but often interconnected, areas of the developing nervous system and in some non-neural tissues. Like the Ten-m family, Ten-m3 plays a critical role in regulating connectivity of the nervous system, particularly in axon pathfinding and synaptic organisation in the motor and visual system. Mutation in the TENM3/ODZ3 gene in human (en) TENM3 (англ. Teneurin transmembrane protein 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 4-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 699 амінокислот, а молекулярна маса — 300 950. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | TENM3 (en) TENM3 (uk) |
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| foaf:depiction | wiki-commons:Special:FilePath/Ten-m3_Structure.png |
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